Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 121 - 130 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_85	23 CD630_03230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31540 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_03200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_08890 - speH Type: Gene Product:S-adenosylmethionine decarboxylase proenzyme \| Pathway: Amine and polyamine biosynthesis \| COG: Amino acid transport and metabolism CD630_03220 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown CD630_03380 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_03160 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_08680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08710 - modC Type: Gene Product:ABC-type transport system, molybdenum-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_03190 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_03210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08900 - speE Type: Gene Product:Spermidine synthase \| Pathway: Amine and polyamine biosynthesis \| COG: Amino acid transport and metabolism CD630_31550 - Type: Gene Product:Putative Fic/Doc-related protein \| Pathway: \| COG: Function unknown CD630_03350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08880 - speA Type: Gene Product:Arginine decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03390 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_03170 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_08700 - modB Type: Gene Product:ABC-type transport system, molybdenum-specificpermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08690 - modA Type: Gene Product:ABC-type transport system, molybdenum-specificextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08720 - maa Type: Gene Product:maltose O-acetyltransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03180 - Type: Gene Product:ABC-type transport system,bacitracin/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_03360 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_08910 - speB Type: Gene Product:Agmatinase (Agmatine ureohydrolase) (AUH) \| Pathway: \| COG: Amino acid transport and metabolism	0.18	0.03	0.55	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_03200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_33600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_102	26 CD630_26450 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05560 - Type: Gene Product:Putative sugar isomerase / endonuclease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32950 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_05520 - prsW Type: Gene Product:Site-1 protease \| Pathway: \| COG: Function unknown CD630_05540 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32930 - pilMN Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: Function unknown CD630_32910 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33320 - Type: Gene Product:Transcriptional regulator, TetR family;Tn916-like, CTn6-Orf8 \| Pathway: \| COG: Transcription CD630_05570 - Type: Gene Product:Putative uridine kinase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_32940 - pilA Type: Gene Product:Type IV pilus protein PilA \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_05550 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32960 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_05530 - Type: Gene Product:Putative RNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_32920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33330 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf9 \| Pathway: \| COG: Transcription	`NA`	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_328	27 CD630_08370 - Type: Gene Product:Nitroreductase \| Pathway: \| COG: Function unknown CD630_30720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27930 - slpA Type: Gene Product:Precursor of the S-layer proteins \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09820 - ubiA Type: Gene Product:Putative UbiA prenyltransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_02740 - Type: Gene Product:Putative iron-containing alcohol dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_20670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_22710 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_14590 - Type: Gene Product:Putative FMN-binding protein \| Pathway: \| COG: Nucleotide transport and metabolism CD630_27010 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_30410 - pepI Type: Gene Product:Proline iminopeptidase (Proline aminopeptidase)(PIP), peptidase S33 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_30730 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33030 - chrA Type: Gene Product:Chromate transport protein ChrA \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09810 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09850 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_01770 - cfa Type: Gene Product:Cyclopropane-fatty-acyl-phospholipid synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09830 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIB \| Pathway: \| COG: Amino acid transport and metabolism CD630_08350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_20620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27940 - cwp12 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_28420 - Type: Gene Product:Nitrilase (carbon-nitrogen hydrolase) \| Pathway: \| COG: Function unknown CD630_22720 - Type: Gene Product:Putative protein-tyrosine phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34040 - cls Type: Gene Product:Cardiolipin synthetase (Cardiolipin synthase) (CLsynthase) \| Pathway: \| COG: Lipid transport and metabolism	0.00000000000016	0.26	0.55	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_215	29 CD630_22480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15431 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15430 - Type: Gene Product:putative FMN-dependent NADH-azoreductase \| Pathway: \| COG: Lipid transport and metabolism CD630_21780 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_30941 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09930 - Type: Gene Product:Putative thioesterase \| Pathway: \| COG: Function unknown CD630_20560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16140 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12330 - cwp26 Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Function unknown CD630_18020 - Type: Gene Product:Putative hydrolase, metallo-beta-lactamasesuperfamily \| Pathway: \| COG: Function unknown CD630_16650 - cysM Type: Gene Product:O-acetylserine (thiol)-lyase (O-acetylserinesulfhydrylase) (OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_28280 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_06310 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20170 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_25020 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_21261 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16640 - Type: Gene Product:Transcriptional regulator, RmlC-type \| Pathway: \| COG: Transcription CD630_22490 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16130 - cotA Type: Gene Product:Spore outer coat layer protein CotA \| Pathway: \| COG: CD630_21790 - Type: Gene Product:Putative anaerobic dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_12320 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_16150 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_09070 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_05770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06300 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_18010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_06320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000000017	0.000000037	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_362	20 CD630_10960 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf29 \| Pathway: \| COG: Function unknown CD630_10970 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn1549-like, CTn4-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_10950 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf30 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10991 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf25 \| Pathway: \| COG: Function unknown CD630_10990 - Type: Gene Product:Two-component response regulator, Tn1549-like,CTn4-Orf26 \| Pathway: \| COG: Signal transduction mechanisms CD630_03650 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn916-like, CTn1-Orf10 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_03760 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf21 \| Pathway: \| COG: Function unknown CD630_11180 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf1 \| Pathway: \| COG: Function unknown CD630_03670 - Type: Gene Product:Two-component sensor histidine kinase,Tn916-like, CTn1-Orf12 \| Pathway: \| COG: Signal transduction mechanisms CD630_03660 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn916-like, CTn1-Orf11 \| Pathway: \| COG: Defense mechanisms CD630_03740 - Type: Gene Product:Putative ATPase Tn916-like, CTn1-Orf19 \| Pathway: \| COG: Function unknown CD630_10980 - Type: Gene Product:Two-component sensor histidine kinase,Tn1549-like, CTn4-Orf27 \| Pathway: \| COG: Signal transduction mechanisms CD630_11150 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn4-Orf4 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_03770 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf22 \| Pathway: \| COG: Function unknown CD630_03700 - Type: Gene Product:Transcriptional regulator, HTH-type Tn916-like,CTn1-Orf15 \| Pathway: \| COG: Transcription CD630_03680 - Type: Gene Product:Two-component response regulator, Tn916-like,CTn1-Orf13 \| Pathway: \| COG: Signal transduction mechanisms CD630_03710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf16 \| Pathway: \| COG: Function unknown CD630_11170 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf2 \| Pathway: \| COG: Function unknown CD630_03730 - Type: Gene Product:Putative membrane protein Tn916-like, CTn1-Orf18 \| Pathway: \| COG: Function unknown CD630_11160 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf3 \| Pathway: \| COG: Function unknown	5.4	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_200	23 CD630_21700 - Type: Gene Product:Putative cNMP-binding regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26600 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28660 - Type: Gene Product:Putative modulator of DNA gyrase, peptidase U62 \| Pathway: \| COG: Function unknown CD630_16310 - sodA Type: Gene Product:Spore coat protein, superoxide dismutase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23470 - Type: Gene Product:Putative Xaa-Pro dipeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28680 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_17090 - mobA Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein A \| Pathway: \| COG: Coenzyme transport and metabolism CD630_21690 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_35780 - Type: Gene Product:Resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_26610 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28670 - Type: Gene Product:Putative regulatory protease, U62 family \| Pathway: \| COG: Function unknown CD630_17100 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Function unknown CD630_07820 - Type: Gene Product:Putative sporulation protein YunB \| Pathway: \| COG: Function unknown CD630_16300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16320 - asnB Type: Gene Product:Asparagine synthetase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_17080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21680 - hcp Type: Gene Product:Hydroxylamine reductase \| Pathway: \| COG: Energy production and conversion CD630_07390 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_35790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32040 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	0.000000000021	0.0001	0.54	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_248	30 CD630_32120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_34810 - Type: Gene Product:Protein-tyrosine phosphatase reductase \| Pathway: \| COG: Signal transduction mechanisms CD630_34870 - rho Type: Gene Product:Transcription termination factor Rho \| Pathway: \| COG: Transcription CD630_34850 - hemK Type: Gene Product:Modification methylase HemK \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34830 - Type: Gene Product:Putative zinc/iron permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10830 - Type: Gene Product:PTS system, lactose/cellobiose specific IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21780 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_09860 - rpsA Type: Gene Product:30S ribosomal protein S1 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_10810 - moeA Type: Gene Product:Molybdenum cofactor biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_14590 - Type: Gene Product:Putative FMN-binding protein \| Pathway: \| COG: Nucleotide transport and metabolism CD630_34030 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33090 - ligA Type: Gene Product:DNA ligase (Polydeoxyribonucleotide synthase[NAD+]) \| Pathway: \| COG: Replication, recombination and repair CD630_27480 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_21850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18000 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17671 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34800 - rpiB2 Type: Gene Product:Ribose-5-phosphate isomerase 2 \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10820 - mobB Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein B \| Pathway: \| COG: Coenzyme transport and metabolism CD630_27490 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Function unknown CD630_34820 - Type: Gene Product:Putative RNA-binding protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34861 - rpmE Type: Gene Product:50S ribosomal protein L31 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21790 - Type: Gene Product:Putative anaerobic dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_34840 - prfA Type: Gene Product:Peptide chain release factor 1 (RF-1) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17990 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_34790 - upp Type: Gene Product:Uracil phosphoribosyltransferase (UMPpyrophosphorylase) (UPRTase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_17680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21860 - Type: Gene Product:Putative phage-like protein \| Pathway: \| COG:	0.06	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_396	4 CD630_06950 - Type: Gene Product:Putative exported metalloendopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_09050 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_15730 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_27060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.54	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_15730 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_155	23 CD630_03550 - int Type: Gene Product:Integrase Tn916-like, CTn1-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_11041 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf18 \| Pathway: \| COG: Function unknown CD630_11180 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf1 \| Pathway: \| COG: Function unknown CD630_03800 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf25 \| Pathway: \| COG: Function unknown CD630_23260 - gatB Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05110 - tndX Type: Gene Product:Recombinase site-specific resolvase familyTn5397, CTn3-Orf3 \| Pathway: \| COG: Replication, recombination and repair CD630_03590 - Type: Gene Product:Putative RNA polymerase sigma factor Tn916-like,CTn1-Orf4 \| Pathway: \| COG: Function unknown CD630_23240 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_11030 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf21 \| Pathway: \| COG: Function unknown CD630_11150 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn4-Orf4 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_11170 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf2 \| Pathway: \| COG: Function unknown CD630_11010 - Type: Gene Product:Putative mobilization protein Tn1549-like,CTn4-Orf23 \| Pathway: \| COG: Function unknown CD630_11130 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf6 \| Pathway: \| COG: Function unknown CD630_03790 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf24 \| Pathway: \| COG: Function unknown CD630_03560 - xis Type: Gene Product:Excisionase Tn916-like, CTn1-Orf2 \| Pathway: \| COG: Function unknown CD630_03810 - Type: Gene Product:Putative replication initiation factorTn916-like, CTn1-Orf26 \| Pathway: \| COG: Transcription CD630_23180 - Type: Gene Product:Putative phosphohexomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03580 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf3 \| Pathway: \| COG: Function unknown CD630_23270 - gatA Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23230 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23250 - gatC Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_11020 - Type: Gene Product:Putative endonuclease relaxase Tn1549-like,CTn4-Orf22 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_11160 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf3 \| Pathway: \| COG: Function unknown	0.000000000000093	0.00036	0.54	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_333	18 CD630_26180 - ileS Type: Gene Product:Isoleucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32560 - valS Type: Gene Product:valyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35400 - metG Type: Gene Product:Methionyl-tRNA synthetase (Methionine--tRNAligase) (MetRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00500 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26950 - asnA Type: Gene Product:Aspartate--ammonia ligase (Asparagine synthetaseA) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_26940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35390 - Type: Gene Product:Putative deoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_00140 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_00490 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25210 - leuS Type: Gene Product:Leucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_07010 - Type: Gene Product:Putative cell-division protein \| Pathway: \| COG: Function unknown CD630_12850 - Type: Gene Product:Putative Holliday junction resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_07000 - pheT Type: Gene Product:Phenylalanyl-tRNA synthetase subunit beta(Phenylalanine--tRNA ligase beta chain) (PheRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15210 - tyrS Type: Gene Product:Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase)(TyrRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12820 - alaS Type: Gene Product:Alanyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0	8.5e-16	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_21110 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`