Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 31 - 40 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_282	26 CD630_28500 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_36190 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_33190 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_t0660 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_32640 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_16020 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_21030 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_14130 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_22160 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26960 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_01670 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_t0460 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_15190 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Function unknown CD630_08980 - Type: Gene Product:Conserved hypothetical protein, DUF1846-family \| Pathway: \| COG: Function unknown CD630_08970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16200 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_28790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28550 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_19420 - trmB Type: Gene Product:tRNA (guanine-N(7)-)-methyltransferase(tRNA(m7G46)-methyltransferase) \| Pathway: tRNA modification \| COG: Energy production and conversion	0.0000016	0.02	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_66	24 CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_29870 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_15990 - thiD Type: Gene Product:Phosphomethylpyrimidine kinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_29840 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_29860 - uppP2 Type: Gene Product:Undecaprenyl-diphosphatase 2 (Undecaprenylpyrophosphate phosphatase 2) (Bacitracin resistance protein2) \| Pathway: \| COG: Defense mechanisms CD630_14880 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_16000 - thiM Type: Gene Product:Hydroxyethylthiazole kinase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_32660 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22430 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09040 - Type: Gene Product:Putative phage integrase \| Pathway: \| COG: Replication, recombination and repair CD630_32070 - Type: Gene Product:Putative multi antimicrobial extrusion protein,MatE family \| Pathway: \| COG: Defense mechanisms CD630_29880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_21130 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_29850 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_14870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14180 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_15420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15390 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16010 - thiE Type: Gene Product:Thiamine-phosphate pyrophosphorylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_32650 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_32670 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_33600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	0.000000000027	0.04	0.62	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_170	31 CD630_28500 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_20270 - Type: Gene Product:N-carbamoyl-L-amino acid hydrolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_12950 - scpA Type: Gene Product:Segregation and condensation protein A \| Pathway: \| COG: Function unknown CD630_15950 - cysE Type: Gene Product:Serine acetyltransferase (SAT) \| Pathway: \| COG: Amino acid transport and metabolism CD630_28660 - Type: Gene Product:Putative modulator of DNA gyrase, peptidase U62 \| Pathway: \| COG: Function unknown CD630_12930 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_26130 - Type: Gene Product:Putative peptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_24810 - ung Type: Gene Product:Uracil-DNA glycosylase (UDG) \| Pathway: \| COG: Replication, recombination and repair CD630_07910 - Type: Gene Product:Conserved hypothetical protein, UPF0029 family \| Pathway: \| COG: Function unknown CD630_19950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_14720 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_19930 - Type: Gene Product:Putative decarboxylase \| Pathway: \| COG: Function unknown CD630_11910 - fbp Type: Gene Product:Fructose-1,6-bisphosphatase \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_33550 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_01680 - Type: Gene Product:Putative cyclic nucleotide-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_12960 - scpB Type: Gene Product:Segregation and condensation protein B \| Pathway: \| COG: Transcription CD630_12920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12940 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Function unknown CD630_24820 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_02750 - splB Type: Gene Product:Spore photoproduct (thymine dimer) lyase, radicalS-adenosylmethionine superfamily \| Pathway: \| COG: Replication, recombination and repair CD630_28680 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_28670 - Type: Gene Product:Putative regulatory protease, U62 family \| Pathway: \| COG: Function unknown CD630_00310 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_15940 - cysK Type: Gene Product:O-acetyl-serine thiol-lyase A(O-acetyl-sulfhydrylase)(OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14730 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_19960 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Signal transduction mechanisms CD630_26960 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_11900 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_33560 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_15310 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_24830 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Coenzyme transport and metabolism	9e-28	0.00000033	0.62	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_122	25 CD630_18300 - kdpE Type: Gene Product:Two-component response regulator KdpE \| Pathway: \| COG: Signal transduction mechanisms CD630_t0010 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_17220 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: CD630_07470 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_06420 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_t0650 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_06400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07460 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_18290 - kdpD Type: Gene Product:Two-component sensor histidine kinase KdpD \| Pathway: \| COG: Signal transduction mechanisms CD630_08390 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06271 - Type: Gene Product:Putative ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_07480 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32050 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_08380 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: CD630_t0690 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_06280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_17210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17230 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_06410 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_05870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32060 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_25621 - rpmB Type: Gene Product:50S ribosomal protein L28 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33722 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf6 \| Pathway: \| COG: Function unknown CD630_12331 - Type: Gene Product:Fragment of phage protein \| Pathway: \| COG:	4.1e-20	0.0000000000035	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_22150 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_59	27 CD630_33000 - engB Type: Gene Product:GTP-binding protein EngB; putative endoglucanase \| Pathway: \| COG: Function unknown CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_35490 - Type: Gene Product:DNA polymerase III, delta prime subunit \| Pathway: \| COG: Replication, recombination and repair CD630_10680 - Type: Gene Product:Putative polysaccharide biosynthesis/sporulationprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10710 - Type: Gene Product:Conserved hypothetical protein, UPF0291 proteinfamily \| Pathway: \| COG: Function unknown CD630_01570 - Type: Gene Product:Fragment of putative membrane protein (Part 2) \| Pathway: \| COG: Function unknown CD630_15450 - Type: Gene Product:Conserved hypothetical protein, DUF1836 family \| Pathway: \| COG: Function unknown CD630_35460 - Type: Gene Product:Putative tetrapyrrole methylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36020 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_35500 - tmk Type: Gene Product:Thymidylate kinase (dTMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_36000 - rolB Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_35480 - Type: Gene Product:Putative YaaT-like protein involved insporulation or related to DNA replication \| Pathway: \| COG: Function unknown CD630_33010 - lon Type: Gene Product:ATP-dependent protease La, S16 peptidase family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_07370 - hisK Type: Gene Product:Histidinol-phosphatase (HolPase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10720 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_35990 - rolA Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_10700 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_10690 - Type: Gene Product:Putative histidinol phosphatase/hydrolase, PHPfamily \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15460 - Type: Gene Product:Putative channel-forming hemolysin \| Pathway: \| COG: Function unknown CD630_19902 - cspC Type: Gene Product:Major cold shock protein CspC \| Pathway: \| COG: Transcription CD630_03070 - Type: Gene Product:Putative chaperone protein \| Pathway: \| COG: Function unknown CD630_35470 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_35510 - Type: Gene Product:Putative arginine decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23100 - cspD Type: Gene Product:Cold shock protein D \| Pathway: \| COG: Transcription CD630_36010 - Type: Gene Product:D-alanyl-D-alanine carboxypeptidase, M15 family(DD-peptidase) (DD-carboxypeptidase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_03080 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.0000000022	0.00022	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_278	29 CD630_12630 - Type: Gene Product:Putative FMN-dependent dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_12610 - Type: Gene Product:Putative ribonucleotide-diphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_07990 - Type: Gene Product:Putative beta-alanine CoA-transferase, familyIII \| Pathway: \| COG: Energy production and conversion CD630_29940 - nrdF Type: Gene Product:Ribonucleoside-diphosphate reductase subunit beta(Ribonucleotide reductase small subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_09190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09170 - Type: Gene Product:Putative phage recombination protein Bet \| Pathway: \| COG: Replication, recombination and repair CD630_17090 - mobA Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein A \| Pathway: \| COG: Coenzyme transport and metabolism CD630_09200 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_32070 - Type: Gene Product:Putative multi antimicrobial extrusion protein,MatE family \| Pathway: \| COG: Defense mechanisms CD630_09150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08110 - Type: Gene Product:Putative cyclic di-GMP regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_09110 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: CD630_09130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12620 - rnhB Type: Gene Product:Ribonuclease HII (RNase HII) \| Pathway: \| COG: Replication, recombination and repair CD630_07980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17690 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_29930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_17080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29950 - nrdE Type: Gene Product:Ribonucleoside-diphosphate reductase subunitalpha (Ribonucleotide reductase large subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_09230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09160 - Type: Gene Product:Putative phage protein involved in bacteriophageresistance \| Pathway: \| COG: Function unknown CD630_09120 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: CD630_17100 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Function unknown CD630_09140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.000013	`NA`	0.61	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_50	42 CD630_20350 - Type: Gene Product:Putative sporulation integral membrane protein \| Pathway: \| COG: Function unknown CD630_18591 - Type: Gene Product:Transcriptional regulator, AbrB family;Tn1549-like, CTn5-Orf17 \| Pathway: \| COG: Transcription CD630_18590 - Type: Gene Product:DNA topoisomerase protein, type IA, Tn1549-like,CTn5-Orf16 \| Pathway: \| COG: Replication, recombination and repair CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18550 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf11 \| Pathway: \| COG: Function unknown CD630_18620 - Type: Gene Product:Putative DNA/RNA helicase Tn1549-like,CTn5-Orf21 \| Pathway: \| COG: Replication, recombination and repair CD630_31480 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: Function unknown CD630_20390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18571 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf14 \| Pathway: \| COG: Function unknown CD630_18570 - Type: Gene Product:Putative cell wall hydrolase Tn1549-like,CTn5-Orf13 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18530 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn5-Orf9 \| Pathway: \| COG: Function unknown CD630_18510 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf7 \| Pathway: \| COG: Function unknown CD630_10170 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_22660 - Type: Gene Product:Putative oxidoreductase, FAD dependent \| Pathway: \| COG: Energy production and conversion CD630_33100 - Type: Gene Product:Putative D-isomer specific 2-hydroxyaciddehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_22620 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_10180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_18600 - Type: Gene Product:Putative conjugative transposon protein DUF1016family, Tn1549-like, CTn5-Orf18 \| Pathway: \| COG: Function unknown CD630_18580 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn5-Orf15 \| Pathway: \| COG: Function unknown CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33120 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20400 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_20360 - Type: Gene Product:Putative peptidylarginine deiminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_31490 - Type: Gene Product:DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_18540 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf10 \| Pathway: \| COG: Function unknown CD630_19941 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19940 - Type: Gene Product:Putative membrane protein, DUF1648 family \| Pathway: \| COG: Function unknown CD630_18560 - Type: Gene Product:Putative hydrolase Tn1549-like, CTn5-Orf12 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_18610 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf19 \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_20380 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_18520 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf8 \| Pathway: \| COG: Function unknown CD630_36140 - Type: Gene Product:Conserved hypothetical protein, DUF1130 family \| Pathway: \| COG: Function unknown CD630_05650 - nth Type: Gene Product:Endonuclease III \| Pathway: \| COG: Replication, recombination and repair CD630_33110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22650 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18630 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf22 \| Pathway: \| COG: Function unknown CD630_20370 - Type: Gene Product:Putative acyl-CoA acyltransferase \| Pathway: \| COG: Function unknown CD630_31500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0	0	0.61	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_405	26 CD630_29220 - Type: Gene Product:Putative phage terminase large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29200 - Type: Gene Product:Putative phage head protein \| Pathway: \| COG: Signal transduction mechanisms CD630_27360 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14182 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17440 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22991 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09450 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_09410 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09430 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: Function unknown CD630_12331 - Type: Gene Product:Fragment of phage protein \| Pathway: \| COG: CD630_29190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29210 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_29230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_12450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09440 - Type: Gene Product:Putative phage terminase, large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29071 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17430 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09562 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09461 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09460 - Type: Gene Product:Putative phage minor head protein \| Pathway: \| COG: Signal transduction mechanisms CD630_09420 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29240 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28630 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_25171 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	1.68156e-44	8.90007e-41	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_341	24 CD630_30880 - Type: Gene Product:Putative cellobiose-phosphate degrading protein \| Pathway: \| COG: Function unknown CD630_28470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27850 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22340 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Signal transduction mechanisms CD630_04341 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf30 \| Pathway: \| COG: CD630_21620 - Type: Gene Product:Putative GCN5-related N-acetyltransferase-likeprotein \| Pathway: \| COG: Function unknown CD630_22360 - Type: Gene Product:Putative glucokinase, ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_34490 - Type: Gene Product:Putative phosphosugar isomerase; putativetagatose-6-phosphate ketose/aldose isomerase AgaS \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_07160 - cooS Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase (CODH) \| Pathway: \| COG: Energy production and conversion CD630_22410 - nanE Type: Gene Product:N-acetylmannosamine-6-phosphate 2-epimerase(ManNAc-6-P epimerase) \| Pathway: Amino-sugar metabolism \| COG: Carbohydrate transport and metabolism CD630_21600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Defense mechanisms CD630_30890 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21590 - Type: Gene Product:Putative membrane protein, DUF1114 family \| Pathway: \| COG: Replication, recombination and repair CD630_28460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21630 - Type: Gene Product:Putative alanyl-tRNA synthetase \| Pathway: \| COG: Function unknown CD630_22350 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_22370 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22400 - nanA Type: Gene Product:Acetylneuraminate lyase \| Pathway: Amino-sugar metabolism \| COG: Amino acid transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_34480 - Type: Gene Product:Putative ketose-bisphophate aldolase class II;putative tagatose-bisphosphate aldolase GatY \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22390 - Type: Gene Product:Putative Na+/solute symporter, SSS family \| Pathway: \| COG: Amino acid transport and metabolism CD630_07170 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, accessory protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	1.3	`NA`	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22340 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Signal transduction mechanisms CD630_22350 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_151	8 CD630_31561 - Type: Gene Product:Fragment of conserved hypothetical protein (Part2) \| Pathway: \| COG: Function unknown, Function unknown CD630_06470 - Type: Gene Product:Fragment of putative fic family protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_33410 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn916-like, CTn6-Orf18 (N-terminal region) \| Pathway: \| COG: Function unknown CD630_17930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21940 - Type: Gene Product:Putative ROK protein \| Pathway: \| COG: Transcription CD630_31110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18120 - Type: Gene Product:Fragment of putative two-component responseregulator (N-terminal region) \| Pathway: \| COG: CD630_16330 - Type: Gene Product:Putative serine protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	`NA`	`NA`	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_30110 - Type: Gene Product:Transcriptional regulator, HxlR family DUF24 \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`