Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 121 - 130 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 2 e-value	Residual	TF Influences
Module_33	18 CD630_t0070 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0350 - tRNA-Gln Type: Gene Product: \| Pathway: \| COG: CD630_t0150 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0330 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0780 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0400 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0320 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0110 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG: CD630_t0580 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0340 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0390 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0120 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0200 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0410 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0300 - tRNA-Thr Type: Gene Product: \| Pathway: \| COG: CD630_t0590 - tRNA-Pro Type: Gene Product: \| Pathway: \| COG: CD630_t0310 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG:	0	0.50	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_145	21 CD630_20900 - Type: Gene Product:Putative xanthine/uracile permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_17540 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_20870 - Type: Gene Product:Putative xanthine dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_22590 - Type: Gene Product:Conserved hypothetical protein with RmlC-likejelly roll fold \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17520 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_22580 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20990 - XdhD Type: Gene Product:Xanthine dehydrogenase subunit XdhD,molybdopterin-binding \| Pathway: \| COG: Energy production and conversion CD630_17530 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_15610 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_17570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20880 - xdhC2 Type: Gene Product:Xanthine dehydrogenase iron-sulfur bindingsubunit XdhC2 \| Pathway: \| COG: Energy production and conversion CD630_20730 - xdhA Type: Gene Product:Xanthine dehydrogenase, molybdenum bindingsubunit \| Pathway: \| COG: Energy production and conversion CD630_20890 - Type: Gene Product:Putative metal-dependent hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_17550 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17551 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_20860 - Type: Gene Product:Putative NAD(P)H-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_21000 - XdhC3 Type: Gene Product:Xanthine dehydrogenase iron-sulfur bindingsubunit XdhC3 \| Pathway: \| COG: Energy production and conversion CD630_21010 - xdhB Type: Gene Product:Xanthine dehydrogenase subunit XdhB, FAD-binding \| Pathway: \| COG: Energy production and conversion CD630_17560 - def1 Type: Gene Product:Peptide deformylase 1 (PDF 1) (Polypeptidedeformylase 1) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_20740 - Type: Gene Product:Putative FAD-binding subunit of xanthinedehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_17580 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Replication, recombination and repair	`NA`	0.49	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_330	18 CD630_15660 - ilvB Type: Gene Product:Acetolactate synthase large subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_14760 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_28490 - phnXW Type: Gene Product:Bifunctional phosphonoacetaldehydehydrolase/aminoethylphosphonate transaminase [Includes:Phosphonoacetaldehyde hydrolase ;2-aminoethylphosphonate--pyruvate transaminase] \| Pathway: \| COG: Amino acid transport and metabolism CD630_28800 - celC Type: Gene Product:PTS system, cellobiose-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15650 - ilvC Type: Gene Product:Ketol-acid reductoisomerase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_28810 - celG Type: Gene Product:Putative cellobiose-phosphate degrading protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28840 - celA Type: Gene Product:PTS system, cellobiose-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05660 - Type: Gene Product:Putative tRNA/rRNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_19350 - spoVS Type: Gene Product:Stage V sporulation protein S \| Pathway: \| COG: Function unknown CD630_05670 - Type: Gene Product:Conserved hypothetical protein, DegV family \| Pathway: \| COG: Function unknown CD630_24800 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08110 - Type: Gene Product:Putative cyclic di-GMP regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription CD630_18930 - Type: Gene Product:Putative oligonucleotide binding regulator \| Pathway: \| COG: Function unknown CD630_28830 - celB Type: Gene Product:PTS system, cellobiose-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28820 - celF Type: Gene Product:Cellobiose-6-phosphate hydrolase, family 4 \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_299	20 CD630_28090 - Type: Gene Product:Conserved hypothetical protein, DUF1540 family \| Pathway: \| COG: Function unknown CD630_29150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29170 - Type: Gene Product:Putative scaffold protein \| Pathway: \| COG: Function unknown CD630_28970 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_03110 - GerG Type: Gene Product:Germination regulator \| Pathway: \| COG: CD630_29000 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_29010 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29030 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_10633 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29120 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_28980 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_29020 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29050 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_10632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29040 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_29090 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29060 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29080 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	`NA`	0.57	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_50	42 CD630_20350 - Type: Gene Product:Putative sporulation integral membrane protein \| Pathway: \| COG: Function unknown CD630_18591 - Type: Gene Product:Transcriptional regulator, AbrB family;Tn1549-like, CTn5-Orf17 \| Pathway: \| COG: Transcription CD630_18590 - Type: Gene Product:DNA topoisomerase protein, type IA, Tn1549-like,CTn5-Orf16 \| Pathway: \| COG: Replication, recombination and repair CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18550 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf11 \| Pathway: \| COG: Function unknown CD630_18620 - Type: Gene Product:Putative DNA/RNA helicase Tn1549-like,CTn5-Orf21 \| Pathway: \| COG: Replication, recombination and repair CD630_31480 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: Function unknown CD630_20390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18571 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf14 \| Pathway: \| COG: Function unknown CD630_18570 - Type: Gene Product:Putative cell wall hydrolase Tn1549-like,CTn5-Orf13 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18530 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn5-Orf9 \| Pathway: \| COG: Function unknown CD630_18510 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf7 \| Pathway: \| COG: Function unknown CD630_10170 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_22660 - Type: Gene Product:Putative oxidoreductase, FAD dependent \| Pathway: \| COG: Energy production and conversion CD630_33100 - Type: Gene Product:Putative D-isomer specific 2-hydroxyaciddehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_22620 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_10180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_18600 - Type: Gene Product:Putative conjugative transposon protein DUF1016family, Tn1549-like, CTn5-Orf18 \| Pathway: \| COG: Function unknown CD630_18580 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn5-Orf15 \| Pathway: \| COG: Function unknown CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33120 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20400 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_20360 - Type: Gene Product:Putative peptidylarginine deiminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_31490 - Type: Gene Product:DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_18540 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf10 \| Pathway: \| COG: Function unknown CD630_19941 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19940 - Type: Gene Product:Putative membrane protein, DUF1648 family \| Pathway: \| COG: Function unknown CD630_18560 - Type: Gene Product:Putative hydrolase Tn1549-like, CTn5-Orf12 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_18610 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf19 \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_20380 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_18520 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf8 \| Pathway: \| COG: Function unknown CD630_36140 - Type: Gene Product:Conserved hypothetical protein, DUF1130 family \| Pathway: \| COG: Function unknown CD630_05650 - nth Type: Gene Product:Endonuclease III \| Pathway: \| COG: Replication, recombination and repair CD630_33110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22650 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18630 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf22 \| Pathway: \| COG: Function unknown CD630_20370 - Type: Gene Product:Putative acyl-CoA acyltransferase \| Pathway: \| COG: Function unknown CD630_31500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0	0.61	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_83	15 CD630_05830 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_25340 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_25350 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_32550 - rgaR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms CD630_20640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28870 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_03410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05840 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08390 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_36250 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_25330 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_21020 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08380 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: CD630_25360 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_347	13 CD630_r0250 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0130 - 16s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0050 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0080 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0280 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19360 - accA Type: Gene Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0200 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19380 - accC Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0140 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19370 - accD Type: Gene Product:Acetyl-CoA carboxylase subunit beta \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19390 - accB Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0020 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0230 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG:	2.8026e-43	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_380	29 CD630_33980 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_36710 - spo0J Type: Gene Product:Stage 0 sporulation protein J, site-specificDNA-binding protein \| Pathway: \| COG: Transcription CD630_36730 - Type: Gene Product:Putative stage 0 sporulation protein, DNA-bindingprotein Spo0J-like \| Pathway: \| COG: Transcription CD630_17350 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_17370 - Type: Gene Product:Putative divalent ion symporter \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_05340 - cheC Type: Gene Product:Chemotaxis protein CheY-P phosphatase CheC \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_08260 - Type: Gene Product:Putative ferric-uptake regulator \| Pathway: \| COG: Transcription CD630_17390 - Type: Gene Product:Two-component response regulator, sigma-54dependent regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_05360 - cheW Type: Gene Product:Purine-binding chemotaxis protein CheW \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_34010 - Type: Gene Product:putative phosphoesterase \| Pathway: \| COG: Replication, recombination and repair CD630_33960 - dnaE Type: Gene Product:DNA polymerase III DnaE subunit alpha \| Pathway: \| COG: Replication, recombination and repair CD630_05380 - Type: Gene Product:Putative methyl-accepting chemotaxis receptor,MCP family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05420 - Type: Gene Product:Putative protein-glutamate methylesterase \| Pathway: \| COG: Signal transduction mechanisms CD630_36720 - soj Type: Gene Product:Transcriptional regulator, sporulation initiationinhibitor, chromosome partitioning protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_05330 - cheY Type: Gene Product:Chemotaxis protein CheY \| Pathway: \| COG: Signal transduction mechanisms CD630_36700 - Type: Gene Product:Putative cysteine desulfurase family protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_33990 - Type: Gene Product:Conserved hypothetical protein, UPF0052 family \| Pathway: \| COG: Function unknown CD630_25640 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17360 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_17380 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_05350 - cheD Type: Gene Product:Probable chemoreceptor glutamine deamidase CheD \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_34000 - Type: Gene Product:Conserved hypothetical protein, UPF0042 family \| Pathway: \| COG: Function unknown CD630_05370 - Type: Gene Product:Putative CheY-like chemosensory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08270 - rbo Type: Gene Product:Rubredoxin oxidoreductase (desulfoferrodoxin) \| Pathway: \| COG: Energy production and conversion CD630_33970 - whiA Type: Gene Product:Putative sporulation transcription regulatorwhiA \| Pathway: \| COG: Transcription CD630_05390 - cheA Type: Gene Product:Chemotaxis protein CheA \| Pathway: \| COG: Signal transduction mechanisms CD630_05410 - cheR Type: Gene Product:Methyl-accepting chemotaxis proteinsmethyltransferase, MCP family \| Pathway: \| COG: Signal transduction mechanisms CD630_34020 - murB Type: Gene Product:UDP-N-acetylenolpyruvoylglucosamine reductase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis	`NA`	0.55	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_08260 - Type: Gene Product:Putative ferric-uptake regulator \| Pathway: \| COG: Transcription CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_20	27 CD630_30250 - Type: Gene Product:Putative ferredoxin, iron-sulphurdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_01720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_35330 - phnL Type: Gene Product:ABC-type transport system, phosphonate-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08450 - Type: Gene Product:Putative nuclease \| Pathway: \| COG: Transcription CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_02960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25920 - fbpA Type: Gene Product:Fibronectin-binding protein A \| Pathway: \| COG: Transcription CD630_08430 - Type: Gene Product:Putative glycosyl transferase, group 1 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35290 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13280 - recA Type: Gene Product:Protein RecA (Recombinase A) \| Pathway: \| COG: Replication, recombination and repair CD630_28100 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Replication, recombination and repair CD630_28550 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23590 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_30260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_09870 - Type: Gene Product:Putative phosphatase/hydrolase \| Pathway: \| COG: Replication, recombination and repair CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_02950 - Type: Gene Product:Putative iron-sulfur-binding protein \| Pathway: \| COG: Energy production and conversion CD630_05250 - Type: Gene Product:Fragment of aminobenzoyl-glutamate transporter(Part 2) \| Pathway: \| COG: Coenzyme transport and metabolism, Coenzyme transport and metabolism CD630_08440 - cwp25 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Function unknown CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_25910 - ltaE Type: Gene Product:Low specificity L-threonine aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_08420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13290 - Type: Gene Product:RNase Y \| Pathway: \| COG: Function unknown	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_381	24 CD630_08480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17130 - moaA Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaA \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17150 - Type: Gene Product:Putative molybdenum cofactor sulfurase \| Pathway: \| COG: Function unknown CD630_01510 - rimI Type: Gene Product:Putative alanine acetyltransferase, ribosomalfamily \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23710 - nadB Type: Gene Product:L-aspartate oxidase (Quinolinate synthetase B) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_05150 - Type: Gene Product:D-alanyl-D-alanine carboxypeptidase, S11peptidase family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06310 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_02160 - Type: Gene Product:Transposase IS200/IS605-like OrfB \| Pathway: \| COG: Replication, recombination and repair CD630_08490 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_01520 - gcp Type: Gene Product:Putative O-sialoglycoprotein endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_17140 - moaC Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaC \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17120 - moaB Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaB \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_23700 - nadC Type: Gene Product:Nicotinate-nucleotide pyrophosphorylase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08500 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23720 - nadA Type: Gene Product:Quinolinate synthetase A \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_02150 - Type: Gene Product:Transposase IS200/IS605-like OrfA \| Pathway: \| COG: Replication, recombination and repair CD630_01490 - Type: Gene Product:Putative P-loop ATPases \| Pathway: \| COG: Function unknown CD630_06320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20450 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription	`NA`	0.52	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`