Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 81 - 90 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_10	29 CD630_11570 - norV Type: Gene Product:Anaerobic nitric oxide reductase flavorubredoxin(FlRd) (FlavoRb) \| Pathway: \| COG: Energy production and conversion CD630_00260 - clpC Type: Gene Product:class III stress response-related ATPase, AAA+superfamily \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_15240 - Type: Gene Product:Putative rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_16230 - Type: Gene Product:NADH-oxygen oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_00240 - mcsA Type: Gene Product:Activator of protein kinase McsB \| Pathway: \| COG: Function unknown CD630_03940 - ldhA Type: Gene Product:D-lactate dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_21660 - msrAB Type: Gene Product:Peptide methionine sulfoxide reductase MsrA/MsrB \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23550 - trxA2 Type: Gene Product:Thioredoxin 2 (Trx2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23570 - grdX Type: Gene Product:Putative glycine reductase complex component \| Pathway: \| COG: Function unknown CD630_14740 - Type: Gene Product:Putative rubrerythrin (Rr) \| Pathway: \| COG: Energy production and conversion CD630_15680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32740 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33100 - Type: Gene Product:Putative D-isomer specific 2-hydroxyaciddehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_15260 - pyrC Type: Gene Product:Dihydroorotase (DHOase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_05600 - nfo Type: Gene Product:Endonuclease IV \| Pathway: \| COG: Replication, recombination and repair CD630_16900 - trxA Type: Gene Product:Thioredoxin \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00230 - ctsR Type: Gene Product:Transcriptional regulator, CtsR family \| Pathway: \| COG: Transcription CD630_23520 - grdA Type: Gene Product:Glycine reductase complex selenoprotein A(selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_23560 - trxB3 Type: Gene Product:Thioredoxin reductase 3 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00250 - mcsB Type: Gene Product:Tyrosine kinase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_11250 - Type: Gene Product:Nitroreductase-family protein \| Pathway: \| COG: Function unknown CD630_23540 - grdE Type: Gene Product:Glycine reductase complex component B subunitsalpha and beta (Selenoprotein PB alpha/beta) [Contains:Betaine reductase component B subunit beta; Betainereductase component B subunit alpha] \| Pathway: \| COG: Function unknown CD630_32730 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15250 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_15350 - sseA Type: Gene Product:3-mercaptopyruvate sulfurtransferase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16910 - trxB Type: Gene Product:Putative thioredoxin-disulfide reductase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.0000036	`NA`	0.37	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_367	32 CD630_27930 - slpA Type: Gene Product:Precursor of the S-layer proteins \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01740 - cooS Type: Gene Product:Carbon monoxide dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_20670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01760 - Type: Gene Product:Putative oxidoreductase, NAD/FAD binding subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35090 - pilO Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: CD630_27870 - cwp84 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27910 - cwp2 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown CD630_35130 - pilA Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Function unknown CD630_14250 - Type: Gene Product:Putative magnesium transporter \| Pathway: \| COG: Function unknown CD630_35110 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_08100 - Type: Gene Product:Putative flavodoxin/nitric oxide synthase \| Pathway: \| COG: Function unknown CD630_35070 - pilU Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_35050 - pilT Type: Gene Product:Type IV pilus twitching motility protein \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_10470 - cwp18 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27840 - cwp6 Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase,autolysin \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27350 - cwp14 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20600 - Type: Gene Product:Putative lipid kinase \| Pathway: \| COG: Lipid transport and metabolism CD630_27900 - Type: Gene Product:Putative LmbE-like deacetylase \| Pathway: \| COG: Function unknown CD630_01750 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_35080 - pilV Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_27860 - cwp5 Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27940 - cwp12 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35120 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_26680 - Type: Gene Product:Transcription antiterminator, licT family \| Pathway: \| COG: Transcription CD630_35100 - pilMN Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Function unknown CD630_35060 - pilK Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_17510 - cwp13 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27890 - cwp66 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	1.9e-27	`NA`	0.46	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_192	23 CD630_27610 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_36550 - purA Type: Gene Product:Adenylosuccinate synthetase (IMP--aspartateligase) (AdSS) (AMPSase) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_17330 - hemE Type: Gene Product:Uroporphyrinogen decarboxylase (URO-D) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_13100 - rbfA Type: Gene Product:Ribosome-binding factor A \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13080 - Type: Gene Product:Ribosomal protein L7Ae/L30e/S12e/Gadd45 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22750 - topB2 Type: Gene Product:DNA topoisomerase III \| Pathway: \| COG: Replication, recombination and repair CD630_07100 - Type: Gene Product:Conserved hypothetical protein, DUF523 family \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_28020 - tgt Type: Gene Product:Queuine tRNA-ribosyltransferase (tRNA-guaninetransglycosylase) (Guanine insertion enzyme) \| Pathway: tRNA modification \| COG: Translation, ribosomal structure and biogenesis CD630_28000 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_28040 - queA Type: Gene Product:S-adenosylmethionine:tRNAribosyltransferase-isomerase (Queuosine biosynthesisprotein QueA) \| Pathway: tRNA modification \| COG: Translation, ribosomal structure and biogenesis CD630_17320 - Type: Gene Product:Putative cobalamin-binding protein \| Pathway: \| COG: Function unknown CD630_13071 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_13070 - nusA Type: Gene Product:Transcription elongation protein \| Pathway: \| COG: Transcription CD630_36560 - Type: Gene Product:Conserved hypothetical protein with a TonB box \| Pathway: \| COG: CD630_17340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_13090 - infB Type: Gene Product:Translation initiation factor IF-2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_07090 - mutS2 Type: Gene Product:DNA mismatch repair protein \| Pathway: \| COG: Replication, recombination and repair CD630_26820 - pfo Type: Gene Product:Pyruvate-ferredoxin oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_28030 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_13050 - dnaF Type: Gene Product:DNA polymerase III PolC-type (PolIII) \| Pathway: \| COG: Replication, recombination and repair	0.00069	`NA`	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_26	6 CD630_07570 - Type: Gene Product:Phosphodiesterases protein \| Pathway: \| COG: Signal transduction mechanisms CD630_18311 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20160 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10150 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.49	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_383	9 CD630_32690 - Type: Gene Product:Putative oligoendopeptidase F, M3B family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31560 - Type: Gene Product:phage integrase \| Pathway: \| COG: Replication, recombination and repair CD630_19902 - cspC Type: Gene Product:Major cold shock protein CspC \| Pathway: \| COG: Transcription CD630_13950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_32700 - Type: Gene Product:Putative magnesium transport ATPase, MgtC/SapBfamily \| Pathway: \| COG: Function unknown CD630_18080 - Type: Gene Product:Pyridoxal-dependent decarboxylase, group IVdecarboxylase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_23100 - cspD Type: Gene Product:Cold shock protein D \| Pathway: \| COG: Transcription CD630_18070 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_12341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	`NA`	`NA`	0.65	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_208	21 CD630_19110 - eutW Type: Gene Product:Two-component sensor histidine kinase,Ethanolamine specific \| Pathway: \| COG: Signal transduction mechanisms CD630_31380 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_19170 - eutE Type: Gene Product:Ethanolamine acetaldehyde oxydoreductase \| Pathway: \| COG: Energy production and conversion CD630_19250 - eutQ Type: Gene Product:Ethanolamine utilization protein, Cupin barrelsfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19160 - eutK Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19130 - eutB Type: Gene Product:Ethanolamine ammonia lyase large subunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_19190 - eutT Type: Gene Product:Ethanolamine corrinoid cobalaminadenosyltransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19120 - eutA Type: Gene Product:Ethanolamine reactivating factor for ammonialyase eutBC \| Pathway: \| COG: Amino acid transport and metabolism CD630_19080 - eutS Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_19090 - eutP Type: Gene Product:Ethanolamine utilization protein, GTPase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_19210 - Type: Gene Product:Putative ethanolamine utilization protein \| Pathway: \| COG: Function unknown CD630_19180 - eutM Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19200 - eutD Type: Gene Product:Putative phosphotransacetylase \| Pathway: Polyol metabolism \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_31370 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19140 - eutC Type: Gene Product:Ethanolamine ammonia lyase small subunit \| Pathway: Amine and polyamine degradation \| COG: Amino acid transport and metabolism CD630_19240 - eutH Type: Gene Product:Ethanolamine transport protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_31360 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19220 - eutN Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19150 - eutL Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19230 - Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.36	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_123	22 CD630_05880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20290 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_14960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_12400 - vanZ Type: Gene Product:Teicoplanin resistance protein \| Pathway: \| COG: Defense mechanisms CD630_15450 - Type: Gene Product:Conserved hypothetical protein, DUF1836 family \| Pathway: \| COG: Function unknown CD630_26870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08920 - cspA Type: Gene Product:Cold shock protein \| Pathway: \| COG: Transcription CD630_35170 - purR Type: Gene Product:Transcriptional regulator, Purine operonrepressor \| Pathway: \| COG: Transcription CD630_05870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21261 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06060 - Type: Gene Product:Fragment of chloride ion channel protein (part1) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20720 - Type: Gene Product:Putative transposase \| Pathway: \| COG: Replication, recombination and repair CD630_35180 - murC Type: Gene Product:UDP-N-acetylmuramate--L-alanine ligase(UDP-N-acetylmuramoyl-L-alanine synthetase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_15460 - Type: Gene Product:Putative channel-forming hemolysin \| Pathway: \| COG: Function unknown CD630_13550 - cspB Type: Gene Product:Cold shock protein CspB \| Pathway: \| COG: Transcription CD630_26840 - Type: Gene Product:Putative flavodoxin-related protein \| Pathway: \| COG: Function unknown CD630_26860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_07250 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit delta \| Pathway: \| COG: Energy production and conversion	0.000000000000032	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_43	25 CD630_15880 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13781 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_17720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20101 - ermC Type: Gene Product:23S rRNA methylase leader peptide \| Pathway: \| COG: CD630_15860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13782 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_20751 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12310 - Type: Gene Product:Putative site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_01800 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_13011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15890 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15870 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04371 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29661 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15850 - Type: Gene Product:Putative N-acetylglucosamine kinase NAGK-like \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription	0.0000000000018	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_305	18 CD630_04160 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf10 \| Pathway: \| COG: Function unknown CD630_04080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04081 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf2 \| Pathway: \| COG: Function unknown CD630_04170 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf11 \| Pathway: \| COG: Function unknown CD630_04190 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf13 \| Pathway: \| COG: Function unknown CD630_04150 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn2-Orf9 \| Pathway: \| COG: Function unknown CD630_04130 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn2-Orf7 \| Pathway: \| COG: Function unknown CD630_04180 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf12 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04060 - Type: Gene Product:Putative tRNA (Uracil-5-)-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04090 - Type: Gene Product:Putative replication initiation proteinTn1549-like, CTn2-Orf2 \| Pathway: \| COG: Replication, recombination and repair CD630_04140 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf8 \| Pathway: \| COG: Function unknown CD630_04110 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf4 \| Pathway: \| COG: Function unknown CD630_04100 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf3 \| Pathway: \| COG: Replication, recombination and repair CD630_04121 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf6 \| Pathway: \| COG: CD630_04120 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn2-Orf5 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04191 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf14 \| Pathway: \| COG: Function unknown CD630_04200 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn2-Orf15 \| Pathway: \| COG: Function unknown CD630_04210 - Type: Gene Product:DNA topoisomerase protein, type IA, Tn1549-like,CTn2-Orf16 \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.48	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_400	19 CD630_01170 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_21360 - uppS Type: Gene Product:Undecaprenyl pyrophosphate synthetase \| Pathway: \| COG: Lipid transport and metabolism CD630_21361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01160 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_01180 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_01140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24460 - Type: Gene Product:Putative aspartyl/glutamyl-tRNA amidotransferasesubunit B-related \| Pathway: \| COG: Function unknown CD630_21350 - cdsA Type: Gene Product:Phosphatidate cytidylyltransferase CdsA \| Pathway: Phospholipid metabolism \| COG: Lipid transport and metabolism CD630_01120 - ptb Type: Gene Product:phosphate butyryltransferase \| Pathway: \| COG: Energy production and conversion CD630_21370 - frr Type: Gene Product:Ribosome-recycling factor \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01150 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_34740 - atpB Type: Gene Product:ATP synthase subunit a \| Pathway: \| COG: Energy production and conversion CD630_01190 - glmM Type: Gene Product:Phosphoglucosamine mutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34720 - atpF Type: Gene Product:ATP synthase subunit b \| Pathway: \| COG: Energy production and conversion CD630_01130 - buk Type: Gene Product:Butyrate kinase (BK) (Branched-chain carboxylicacid kinase) \| Pathway: \| COG: Energy production and conversion CD630_34760 - atpZ Type: Gene Product:ATP synthase transporter \| Pathway: \| COG: Function unknown CD630_34670 - atpC Type: Gene Product:ATP synthase epsilon chain \| Pathway: \| COG: Energy production and conversion CD630_21400 - rpsB Type: Gene Product:30S ribosomal protein S2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21950 - ftnA Type: Gene Product:Ferritin \| Pathway: \| COG: Inorganic ion transport and metabolism	`NA`	`NA`	0.32	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`