Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 11 - 20 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_372	7 CD630_33690 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13820 - glpK2 Type: Gene Product:Glycerol kinase 1 (ATP:glycerol3-phosphotransferase 1) (Glycerokinase 1) (GK 1) \| Pathway: Polyol metabolism \| COG: Energy production and conversion CD630_22850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_24190 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_01600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_14930 - Type: Gene Product:Putative 3-methyladenine DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair	5.8	`NA`	0.40	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_18830 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_362	20 CD630_10960 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf29 \| Pathway: \| COG: Function unknown CD630_10970 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn1549-like, CTn4-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_10950 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf30 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10991 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf25 \| Pathway: \| COG: Function unknown CD630_10990 - Type: Gene Product:Two-component response regulator, Tn1549-like,CTn4-Orf26 \| Pathway: \| COG: Signal transduction mechanisms CD630_03650 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn916-like, CTn1-Orf10 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_03760 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf21 \| Pathway: \| COG: Function unknown CD630_11180 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf1 \| Pathway: \| COG: Function unknown CD630_03670 - Type: Gene Product:Two-component sensor histidine kinase,Tn916-like, CTn1-Orf12 \| Pathway: \| COG: Signal transduction mechanisms CD630_03660 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn916-like, CTn1-Orf11 \| Pathway: \| COG: Defense mechanisms CD630_03740 - Type: Gene Product:Putative ATPase Tn916-like, CTn1-Orf19 \| Pathway: \| COG: Function unknown CD630_10980 - Type: Gene Product:Two-component sensor histidine kinase,Tn1549-like, CTn4-Orf27 \| Pathway: \| COG: Signal transduction mechanisms CD630_11150 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn4-Orf4 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_03770 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf22 \| Pathway: \| COG: Function unknown CD630_03700 - Type: Gene Product:Transcriptional regulator, HTH-type Tn916-like,CTn1-Orf15 \| Pathway: \| COG: Transcription CD630_03680 - Type: Gene Product:Two-component response regulator, Tn916-like,CTn1-Orf13 \| Pathway: \| COG: Signal transduction mechanisms CD630_03710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf16 \| Pathway: \| COG: Function unknown CD630_11170 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf2 \| Pathway: \| COG: Function unknown CD630_03730 - Type: Gene Product:Putative membrane protein Tn916-like, CTn1-Orf18 \| Pathway: \| COG: Function unknown CD630_11160 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf3 \| Pathway: \| COG: Function unknown	5.4	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_275	23 CD630_27470 - Type: Gene Product:Putative ubiquinone biosynthesis protein \| Pathway: \| COG: Coenzyme transport and metabolism CD630_33040 - clpX Type: Gene Product:ATP-dependent Clp protease ATP-binding subunitclpX \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_35590 - ftsH2 Type: Gene Product:Cell division protease FtsH2 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_36090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27390 - aspS Type: Gene Product:Aspartyl-tRNA synthetase (Aspartate--tRNA ligase)(AspRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26970 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00510 - gltX Type: Gene Product:Glutamyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24460 - Type: Gene Product:Putative aspartyl/glutamyl-tRNA amidotransferasesubunit B-related \| Pathway: \| COG: Function unknown CD630_27151 - mldC Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: CD630_27170 - mldA Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_36100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_33070 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_27460 - recJ Type: Gene Product:Single-stranded-DNA-specific exonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_33050 - clpP1 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 1 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26990 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05080 - tetM Type: Gene Product:Tetracycline resistance protein Tn5397 \| Pathway: \| COG: Signal transduction mechanisms CD630_27160 - mldB Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_33080 - rph Type: Gene Product:Bifunctional enzyme, tRNA nucleotidyltransferase; Nucleoside-triphosphatase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27410 - hemZ Type: Gene Product:Coproporphyrinogen III oxidase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_35600 - tilS Type: Gene Product:tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_27450 - apt Type: Gene Product:Adenine phosphoribosyltransferase (APRT) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_33060 - tig Type: Gene Product:Trigger factor (TF) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	4.2	`NA`	0.33	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_281	27 CD630_20430 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_09290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29120 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09300 - Type: Gene Product:Putative phage reductase \| Pathway: \| COG: Function unknown CD630_09301 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09360 - Type: Gene Product:Putative phage endodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_06110 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09320 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_04950 - Type: Gene Product:Fragment of putative regulatory protein (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_18120 - Type: Gene Product:Fragment of putative two-component responseregulator (N-terminal region) \| Pathway: \| COG: CD630_09380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09280 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_22190 - Type: Gene Product:Fragment of conjugative transposon protein(central region) \| Pathway: \| COG: Function unknown CD630_29150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09350 - Type: Gene Product:Putative S-adenosyl-L-methionine-dependentmethyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_09270 - Type: Gene Product:Putative phage DNA modification methylase \| Pathway: \| COG: Replication, recombination and repair CD630_06100 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23051 - Type: Gene Product:Fragment of transposase (N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_09250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09370 - Type: Gene Product:Putative phage anti-repressor \| Pathway: \| COG: Transcription CD630_09330 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09310 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28390 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	4.1	`NA`	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_113	11 CD630_21170 - trxB Type: Gene Product:Thioredoxin reductase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25400 - Type: Gene Product:Coenzyme A disulfide reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_30360 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_08670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26691 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_09740 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26120 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_17452 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	4	`NA`	0.57	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_150	24 CD630_30440 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_12090 - recN Type: Gene Product:DNA repair protein RecN (Recombination proteinN) \| Pathway: \| COG: Replication, recombination and repair CD630_33741 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf9 \| Pathway: \| COG: Function unknown CD630_33740 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf8 \| Pathway: \| COG: Function unknown CD630_33760 - Type: Gene Product:Putative transcriptional regulator Tn916-like,CTn7-Orf11 \| Pathway: \| COG: Transcription CD630_12010 - nusB Type: Gene Product:N utilization substance protein B homolog(Protein NusB) \| Pathway: \| COG: Transcription CD630_12050 - ispA Type: Gene Product:Geranyltranstransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_12030 - xseA Type: Gene Product:Exodeoxyribonuclease 7 large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_12070 - dxs Type: Gene Product:1-deoxy-D-xylulose-5-phosphate synthase \| Pathway: Metabolic intermediate biosynthesis \| COG: Coenzyme transport and metabolism CD630_33750 - mgtC Type: Gene Product:Magnesium-transporting ATPase protein C;Tn916-like, CTn7-Orf10 \| Pathway: \| COG: Function unknown CD630_30450 - Type: Gene Product:Putative ATPase, BadF/BadG/BcrA/BcrD type \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_33730 - mgtA Type: Gene Product:Magnesium-transporting ATPase, P-type 1;Tn916-like, CTn7-Orf7 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_03310 - ppiB Type: Gene Product:Peptidyl-prolyl cis-trans isomerase B (PPIase B)(Rotamase B) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12080 - Type: Gene Product:Putative RNA-binding S4-domain protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33770 - mgtA Type: Gene Product:Magnesium-transporting ATPase, P-type 1;Tn916-like, CTn7-Orf12 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_30510 - anmK Type: Gene Product:Anhydro-N-acetylmuramic acid kinase (AnhMurNAckinase) \| Pathway: Amino-sugar metabolism \| COG: Posttranslational modification, protein turnover, chaperones CD630_30500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_03290 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_12000 - Type: Gene Product:Conserved hypothetical protein, DUF322 familly \| Pathway: \| COG: Function unknown CD630_12020 - gcp Type: Gene Product:O-sialoglycoprotein endopeptidase, peptidase M22family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12060 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12040 - xseB Type: Gene Product:Exodeoxyribonuclease VII small subunit \| Pathway: \| COG: Replication, recombination and repair CD630_33780 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf13 \| Pathway: \| COG: Energy production and conversion CD630_03300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	3.6	`NA`	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_171	21 CD630_25740 - thiN Type: Gene Product:Thiamine pyrophosphokinase (TPK) (Thiaminediphospho kinase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_25830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25850 - def2 Type: Gene Product:Peptide deformylase 2 (PDF 2) (Polypeptidedeformylase 2 ) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25840 - fmt Type: Gene Product:Methionyl-tRNA formyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25810 - rsmB Type: Gene Product:Ribosomal RNA small subunit methyltransferase B(rRNA (cytosine-C(5)-)-methyltransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_16870 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_25760 - Type: Gene Product:Putative GTPase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25800 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25820 - Type: Gene Product:Putative metal-dependent peptidase \| Pathway: \| COG: Function unknown CD630_16880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_25890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25750 - rpe Type: Gene Product:Ribulose-phosphate 3-epimerase(Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16890 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_25880 - gmk Type: Gene Product:Guanylate kinase (GMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_16850 - Type: Gene Product:Putative binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_25860 - priA Type: Gene Product:Primosomal protein N' (ATP-dependent helicasepriA) (Replication factor Y) \| Pathway: \| COG: Replication, recombination and repair CD630_25871 - rpoZ Type: Gene Product:DNA-directed RNA polymerase subunit omega (RNAPomega subunit) (Transcriptase subunit omega) (RNApolymerase omega subunit) \| Pathway: \| COG: Transcription CD630_19970 - Type: Gene Product:Putative proline iminopeptidase (PIP), S33family \| Pathway: \| COG: Function unknown CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_25870 - coaBC Type: Gene Product:Coenzyme A biosynthesis bifunctional proteinCoaBC; phosphopantothenoylcysteinesynthetase/decarboxylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription	3.2	`NA`	0.42	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_265	5 CD630_22600 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_24220 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_12600 - brnQ-2 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_24210 - Type: Gene Product:Putative amidohydrolase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31690 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown	3.1	`NA`	0.49	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10230 - Type: Gene Product:Putative transcriptional regulator, HTH \| Pathway: \| COG: Transcription CD630_15580 - sigV Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_223	19 CD630_35680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35700 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_26880 - sspA Type: Gene Product:Small, acid-soluble spore protein alpha \| Pathway: \| COG: Function unknown CD630_35690 - Type: Gene Product:Sporulation-specific protease \| Pathway: \| COG: Function unknown CD630_35710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_35701 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_35670 - SipL Type: Gene Product:SpoIVA-Interacting protein, coat localization \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35650 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_26890 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_20510 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26910 - hpt Type: Gene Product:Hypoxanthine phosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_26900 - Type: Gene Product:Putative membrane-associated phosphatase \| Pathway: \| COG: Lipid transport and metabolism CD630_35640 - spoIIR Type: Gene Product:Pro-sigma(E) endopeptidase (stage IIsporulation) \| Pathway: \| COG: Function unknown CD630_35660 - ispE Type: Gene Product:4-diphosphocytidyl-2-C-methyl-D-erythritol kinase(4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_20500 - rluB Type: Gene Product:Ribosomal large subunit pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34560 - Type: Gene Product:5-formyltetrahydrofolate cyclo-ligase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_20490 - Type: Gene Product:Putative rRNA methylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_35630 - sleB Type: Gene Product:Spore-cortex-lytic protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	2.6	`NA`	0.47	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_234	24 CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_33861 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf23 \| Pathway: \| COG: Function unknown CD630_31000 - Type: Gene Product:Putative C4-dicarboxylate anaerobic carrier, DcuCfamily \| Pathway: \| COG: Function unknown CD630_32990 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_16270 - vanY Type: Gene Product:D-alanyl-D-alanine carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_33880 - Type: Gene Product:Putative replication initiation factorTn916-like, CTn7-Orf27 \| Pathway: \| COG: Transcription CD630_06500 - Type: Gene Product:Putative peptidase, S9 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_01990 - Type: Gene Product:Putative membrane-associated nucleotidase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_04600 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_24351 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28380 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_20171 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06490 - Type: Gene Product:Putative peptidase, S9 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_03050 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19490 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_04560 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_16200 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06510 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_16260 - vanG Type: Gene Product:D-alanine--D-alanine ligase 2 \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_22010 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16280 - vanT Type: Gene Product:Alanine racemase 1 \| Pathway: Amino-acid biosynthesis \| COG: Cell wall/membrane/envelope biogenesis CD630_30990 - Type: Gene Product:Putative amidohydrolase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_04590 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms	2.4	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`