Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 11 - 20 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_121	20 CD630_27720 - tuaG Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27730 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15570 - Type: Gene Product:Putative peptidylprolyl isomerase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27710 - rkpK Type: Gene Product:UDP-glucose 6-dehydrogenase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27750 - Type: Gene Product:Putative glycerophosphotransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15560 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27760 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15590 - rsiV Type: Gene Product:Anti Sigma Factor, ECF family \| Pathway: \| COG: Function unknown CD630_27740 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27800 - pgm Type: Gene Product:Alpha-phosphoglucomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15610 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27780 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15580 - sigV Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_15600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27690 - Type: Gene Product:Putative polysaccharide biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27700 - Type: Gene Product:Putative glycosyl transferase, group 1 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27820 - cwp7 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27790 - manC Type: Gene Product:Putative mannose-1-phosphate guanylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.40	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_10230 - Type: Gene Product:Putative transcriptional regulator, HTH \| Pathway: \| COG: Transcription CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_41	23 CD630_35940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_28520 - dltB Type: Gene Product:D-alanyl transferase DltB, MBOAT family \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_28540 - dltD Type: Gene Product:D-alanine transferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_22260 - sat Type: Gene Product:Streptogramin A acetyltransferase (Virginiamycinacetyltransferase D) (Vat(D)) \| Pathway: \| COG: Function unknown CD630_26030 - cdtR Type: Gene Product:Clostridium difficile binary toxin regulatorygene, LytTR family \| Pathway: \| COG: Signal transduction mechanisms CD630_16250 - vanS Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_01300 - metK Type: Gene Product:S-adenosylmethionine synthetase \| Pathway: Amino-acid biosynthesis \| COG: Coenzyme transport and metabolism CD630_17840 - truA2 Type: Gene Product:Pseudouridylate synthase (tRNA pseudouridinesynthase A) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27151 - mldC Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: CD630_27170 - mldA Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_35930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_28510 - dltC Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 2(D-alanyl carrier protein) (DCP) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_28530 - dltA Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 1 \| Pathway: Cell wall biogenesis \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16220 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_17790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_23350 - guaB Type: Gene Product:Inositol-5'-monophosphate dehydrogenase (IMPdehydrogenase) (IMPDH) (IMPD) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_16240 - vanR Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27160 - mldB Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_06680 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_01980 - guaA Type: Gene Product:Glutamine amidotransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_17830 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17810 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown	0.0000000032	`NA`	0.46	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_202	6 CD630_17720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26040 - Type: Gene Product:Fragment of ADP-ribosyltransferase CdtAB (Part1) \| Pathway: \| COG: CD630_28240 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_33810 - Type: Gene Product:Fragment of putative membrane protein Tn916-like,CTn7-orf17 (Part 2) \| Pathway: \| COG: Function unknown, Function unknown CD630_32210 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_18130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17250 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_383	9 CD630_32690 - Type: Gene Product:Putative oligoendopeptidase F, M3B family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31560 - Type: Gene Product:phage integrase \| Pathway: \| COG: Replication, recombination and repair CD630_19902 - cspC Type: Gene Product:Major cold shock protein CspC \| Pathway: \| COG: Transcription CD630_13950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_32700 - Type: Gene Product:Putative magnesium transport ATPase, MgtC/SapBfamily \| Pathway: \| COG: Function unknown CD630_18080 - Type: Gene Product:Pyridoxal-dependent decarboxylase, group IVdecarboxylase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_23100 - cspD Type: Gene Product:Cold shock protein D \| Pathway: \| COG: Transcription CD630_18070 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_12341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	`NA`	`NA`	0.65	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_218	19 CD630_04351 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf32 \| Pathway: \| COG: CD630_04360 - Type: Gene Product:Putative recombinase Tn1549-like, CTn2-Orf34 \| Pathway: \| COG: Replication, recombination and repair CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_33722 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf6 \| Pathway: \| COG: Function unknown CD630_21130 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.49	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_399	18 CD630_26200 - Type: Gene Product:Putative RNA-binding cell division protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26190 - Type: Gene Product:Putative cell-division initiation protein DivIVA \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_26210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01940 - groL Type: Gene Product:60 kDa chaperonin (Protein Cpn60) (GroELprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26230 - Type: Gene Product:Putative pyridoxal 5'-phosphate-dependent enzyme \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19390 - accB Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19380 - accC Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19370 - accD Type: Gene Product:Acetyl-CoA carboxylase subunit beta \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_01930 - groS Type: Gene Product:10 kDa chaperonin (Protein Cpn10) (GroESprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_34740 - atpB Type: Gene Product:ATP synthase subunit a \| Pathway: \| COG: Energy production and conversion CD630_34720 - atpF Type: Gene Product:ATP synthase subunit b \| Pathway: \| COG: Energy production and conversion CD630_34730 - atpE Type: Gene Product:ATP synthase subunit c \| Pathway: \| COG: Energy production and conversion CD630_34760 - atpZ Type: Gene Product:ATP synthase transporter \| Pathway: \| COG: Function unknown CD630_34670 - atpC Type: Gene Product:ATP synthase epsilon chain \| Pathway: \| COG: Energy production and conversion CD630_26220 - sepF Type: Gene Product:Cell division protein SepF \| Pathway: \| COG: Function unknown CD630_26240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34750 - atpI Type: Gene Product:ATP synthase subunit I \| Pathway: \| COG: Function unknown CD630_19360 - accA Type: Gene Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism	`NA`	`NA`	0.26	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_153	21 CD630_26850 - Type: Gene Product:Putative sporulation stage II, protein E \| Pathway: \| COG: Signal transduction mechanisms CD630_18910 - Type: Gene Product:Fragment of ABC-type transport system,substrate-binding protein (Part 2) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism	`NA`	`NA`	0.42	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_315	32 CD630_28450 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_14920 - Type: Gene Product:Histidine kinase, negative regulator ofsporulation \| Pathway: \| COG: Signal transduction mechanisms CD630_04430 - ortA Type: Gene Product:2-amino-4-ketopentanoate thiolase alpha subunit \| Pathway: \| COG: Function unknown CD630_04470 - Type: Gene Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase \| Pathway: \| COG: Function unknown CD630_06710 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_04450 - oraS Type: Gene Product:D-ornithine aminomutase S component \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_35420 - spmA Type: Gene Product:Spore maturation protein A \| Pathway: \| COG: Function unknown CD630_35810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08640 - Type: Gene Product:Maltose-6'-phosphate glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04480 - orr Type: Gene Product:ornithine racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_17610 - Type: Gene Product:Putative phenazine biosynthesis PhzC/PhzFprotein \| Pathway: \| COG: Function unknown CD630_13010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04420 - ord Type: Gene Product:2,4-diaminopentanoate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04460 - oraE Type: Gene Product:D-ornithine aminomutase E component \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_35820 - Type: Gene Product:Putative pseudouridine synthase RsuA-like \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04440 - ortB Type: Gene Product:2-amino-4-ketopentanoate thiolase beta subunit \| Pathway: \| COG: Function unknown CD630_08630 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04490 - Type: Gene Product:Na+/H+ antiporter, NhaA family \| Pathway: \| COG: Energy production and conversion CD630_23330 - mtlR Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_35410 - spmB Type: Gene Product:Spore maturation protein B \| Pathway: \| COG: Function unknown CD630_35800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35830 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17600 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_14020 - glpQ Type: Gene Product:Glycerophosphoryl diester phosphodiesterase \| Pathway: \| COG: Energy production and conversion	0.00000000000083	`NA`	0.43	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_235	26 CD630_24180 - Type: Gene Product:PTS system, Sorbitol-like IIC component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16170 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_34440 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34460 - Type: Gene Product:Aminopeptidase, M42 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_32830 - pflE Type: Gene Product:Pyruvate formate-lyase (activating enzyme) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_34420 - Type: Gene Product:Putative peptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_07670 - srlB Type: Gene Product:PTS system, sorbitol-specific IIA component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown CD630_08530 - oppB Type: Gene Product:ABC-type transport system, oligopeptide-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08550 - oppA Type: Gene Product:ABC-type transport system, oligopeptide-familyextracellular solute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_24170 - Type: Gene Product:PTS system, Sorbitol-like IIB component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04532 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07960 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_16190 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_07680 - srlD Type: Gene Product:Sorbitol 6-phosphate 2-dehydrogenase (Glucitol) \| Pathway: \| COG: Function unknown CD630_34450 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07640 - srlA Type: Gene Product:PTS system, sorbitol-specific IIC component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34410 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase (PLP-dependent transferase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_07970 - Type: Gene Product:Putative pyruvate carboxyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_34470 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_34430 - Type: Gene Product:PTS system, lactose/cellobiose-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08560 - oppD Type: Gene Product:ABC-type transport system, ATP-binding component \| Pathway: \| COG: Amino acid transport and metabolism, Inorganic ion transport and metabolism CD630_07620 - srlR Type: Gene Product:PTS operon regulator \| Pathway: \| COG: Transcription CD630_32820 - pflD Type: Gene Product:Pyruvate formate-lyase \| Pathway: \| COG: Energy production and conversion CD630_08540 - oppC Type: Gene Product:ABC-type transport system, oligopeptide-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism	0.00000014	`NA`	0.58	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_07620 - srlR Type: Gene Product:PTS operon regulator \| Pathway: \| COG: Transcription CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_336	27 CD630_10460 - pepT Type: Gene Product:Peptidase T \| Pathway: \| COG: Amino acid transport and metabolism CD630_28470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04360 - Type: Gene Product:Putative recombinase Tn1549-like, CTn2-Orf34 \| Pathway: \| COG: Replication, recombination and repair CD630_17680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21640 - ldh Type: Gene Product:L-lactate dehydrogenase (L-LDH) \| Pathway: Fermentation \| COG: Energy production and conversion CD630_06420 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_06400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18820 - Type: Gene Product:Site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_31820 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16120 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_32320 - CdsB Type: Gene Product:Cysteine desulfidase \| Pathway: \| COG: Function unknown CD630_08940 - Type: Gene Product:Putative iron-dependent hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_13790 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_06590 - tcdR Type: Gene Product:Alternative RNA polymerase sigma factors \| Pathway: \| COG: CD630_27510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12600 - brnQ-2 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_30050 - Type: Gene Product:Transcriptional regulator, IclR family \| Pathway: \| COG: Transcription CD630_06410 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_22130 - cynT Type: Gene Product:Carbonic anhydrase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06300 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_10470 - cwp18 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26250 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Carbohydrate transport and metabolism	1.9e-23	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`