Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 11 - 20 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_108	11 CD630_05240 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_15960 - map2 Type: Gene Product:Methionine aminopeptidase Map2 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08990 - dinB Type: Gene Product:DNA polymerase IV (Pol IV) \| Pathway: \| COG: Replication, recombination and repair CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_21241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06550 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_23040 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_109	26 CD630_19070 - eutG Type: Gene Product:Ethanolamine iron-dependent Alcoholdehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_01100 - Type: Gene Product:Conserved hypothetical protein, CHP00159 family \| Pathway: \| COG: Function unknown CD630_12110 - Type: Gene Product:Putative N-acetyltransferase \| Pathway: \| COG: Transcription CD630_12130 - spoIVB Type: Gene Product:Stage IV sporulation protein B, peptidase S55family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13560 - Type: Gene Product:Putative CBS domain-containing protein \| Pathway: \| COG: Function unknown CD630_23860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23840 - Type: Gene Product:Putative diguanylate cyclase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_24560 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_09970 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_25390 - rnz Type: Gene Product:Ribonuclease Z (RNase Z) (tRNase Z) (tRNA 3endonuclease) \| Pathway: \| COG: Function unknown CD630_22020 - Type: Gene Product:Putative Na+/solute symporter, SSS family \| Pathway: \| COG: Amino acid transport and metabolism CD630_19450 - Type: Gene Product:Putative enzyme \| Pathway: \| COG: Amino acid transport and metabolism CD630_12120 - bltD Type: Gene Product:Diamine N-acetyltransferase \| Pathway: \| COG: Transcription CD630_27510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_23850 - Type: Gene Product:Putative diguanylate cyclase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_01110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23830 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_23780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_19920 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_24570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_25380 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_11560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19460 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_22030 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription	0.0000000023	0.03	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_11	22 CD630_11480 - Type: Gene Product:Putative penicillin-binding protein with aN-terminal TonB-box \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11510 - minE Type: Gene Product:Cell division topological specificity factor \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_01720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_13350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_11440 - radC Type: Gene Product:DNA repair protein RadC homolog \| Pathway: \| COG: Replication, recombination and repair CD630_32990 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11530 - mgsA Type: Gene Product:Methylglyoxal synthase (MGS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28270 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_28250 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_28280 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33260 - Type: Gene Product:Integrase, lambdoid phage family Tn916-like,CTn6-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_11500 - minD Type: Gene Product:Septum site-determining protein MinD (Celldivision inhibitor MinD) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11490 - minC Type: Gene Product:Cell division regulator (septum placement) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11470 - Type: Gene Product:Putative permease \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11520 - mrdB Type: Gene Product:Rod shape-determining protein MrdB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11450 - mreB2 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_28260 - Type: Gene Product:Putative aldolase \| Pathway: \| COG: Energy production and conversion CD630_11430 - Type: Gene Product:Putative Maf-like protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_27040 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_33270 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf2 \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_110	20 CD630_33682 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19900 - Type: Gene Product:Putative protein with SH3 domain \| Pathway: \| COG: Function unknown CD630_19903 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10521 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26930 - Type: Gene Product:Sodium:dicarboxylate symporter family protein \| Pathway: \| COG: Energy production and conversion CD630_30550 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_05770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11730 - Type: Gene Product:Putative FAD-linked oxidase \| Pathway: \| COG: Energy production and conversion CD630_30560 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_25150 - Type: Gene Product:Putative L-aspartate-beta-decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_11700 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11720 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_11350 - Type: Gene Product:Putative SH3-domain protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27970 - Type: Gene Product:Putative calcium-binding adhesion protein \| Pathway: \| COG: Function unknown CD630_31570 - smpB Type: Gene Product:SsrA-binding protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_11340 - gloA Type: Gene Product:Lactoylglutathione lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25160 - ansB Type: Gene Product:L-asparaginase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	6.70003e-41	1.6e-25	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_111	23 CD630_03550 - int Type: Gene Product:Integrase Tn916-like, CTn1-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_33700 - Type: Gene Product:Putative recombinase Tn916-like, CTn7-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_15950 - cysE Type: Gene Product:Serine acetyltransferase (SAT) \| Pathway: \| COG: Amino acid transport and metabolism CD630_05190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00190 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26930 - Type: Gene Product:Sodium:dicarboxylate symporter family protein \| Pathway: \| COG: Energy production and conversion CD630_34580 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21280 - ispG Type: Gene Product:4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_16960 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_35950 - Type: Gene Product:Aminopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21300 - dxr Type: Gene Product:1-deoxy-D-xylulose 5-phosphate reductoisomerase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_09930 - Type: Gene Product:Putative thioesterase \| Pathway: \| COG: Function unknown CD630_05081 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf6 \| Pathway: \| COG: Function unknown CD630_15940 - cysK Type: Gene Product:O-acetyl-serine thiol-lyase A(O-acetyl-sulfhydrylase)(OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_36140 - Type: Gene Product:Conserved hypothetical protein, DUF1130 family \| Pathway: \| COG: Function unknown CD630_08610 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02970 - bioB Type: Gene Product:Biotin synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_21290 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05650 - nth Type: Gene Product:Endonuclease III \| Pathway: \| COG: Replication, recombination and repair CD630_08930 - Type: Gene Product:Putative iron-dependent hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_05610 - Type: Gene Product:Putative aldo/keto reductase ; putativeferredoxin \| Pathway: \| COG: Energy production and conversion CD630_08070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000000000027	`NA`	0.54	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_112	21 CD630_09640 - Type: Gene Product:Putative phage baseplate assembly protein \| Pathway: \| COG: Function unknown CD630_09570 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_09620 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_11550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09590 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_09700 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09630 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09710 - Type: Gene Product:Putative phage holin protein \| Pathway: \| COG: Function unknown CD630_09670 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09610 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09720 - Type: Gene Product:Putative phage-related cell wall hydrolase(endolysin) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11540 - cdPadR1 Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_09730 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09650 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09580 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09680 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09600 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09690 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09660 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	6.7	`NA`	0.42	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_113	11 CD630_21170 - trxB Type: Gene Product:Thioredoxin reductase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25400 - Type: Gene Product:Coenzyme A disulfide reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_30360 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_08670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26691 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_09740 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26120 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_17452 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	4	`NA`	0.57	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_114	25 CD630_19010 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_21600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Defense mechanisms CD630_29650 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_17070 - Type: Gene Product:Putative C4-dicarboxylate anaerobic carrier, DcuCfamily \| Pathway: \| COG: Function unknown CD630_09562 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_11260 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_06980 - Type: Gene Product:Putative tRNA/rRNA methyltransferase, SpoU \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_19810 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_15740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14600 - Type: Gene Product:Putative phosphohydrolase, HD superfamily \| Pathway: \| COG: Function unknown CD630_16670 - Type: Gene Product:Putative maltose O-acetyltransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_06270 - Type: Gene Product:Putative transcriptional regulator, activatorMor \| Pathway: \| COG: CD630_06260 - Type: Gene Product:Putative replicative helicase DnaB-like \| Pathway: \| COG: Replication, recombination and repair CD630_20420 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_06090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Nucleotide transport and metabolism CD630_14690 - cwp20 Type: Gene Product:Putative cell surface protein ; putativepenicillin-binding protein \| Pathway: \| COG: Defense mechanisms CD630_21590 - Type: Gene Product:Putative membrane protein, DUF1114 family \| Pathway: \| COG: Replication, recombination and repair CD630_28730 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_21650 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_19710 - Type: Gene Product:Putative protein, Sir2 family; putativesilencing, chromosome stability or ageing; putative ADPribosyltransferase \| Pathway: \| COG: Function unknown CD630_22440 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_18500 - Type: Gene Product:Transcriptional regulator, AraC family;Tn1549-like, CTn5-Orf6 \| Pathway: \| COG: Transcription CD630_18830 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_15150 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_19880 - Type: Gene Product:Putative tryptophan transport protein \| Pathway: \| COG: Function unknown	0.0000000089	`NA`	0.67	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_115	24 CD630_00670 - rpoC Type: Gene Product:DNA-directed RNA polymerase subunit beta' \| Pathway: \| COG: Transcription CD630_26720 - appA Type: Gene Product:ABC-type transport system, oligopeptide-familysolute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_26700 - appF Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_00590 - secE Type: Gene Product:Preprotein translocase SecE subunit \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_00610 - rplK Type: Gene Product:50S ribosomal protein L11 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00630 - rplJ Type: Gene Product:50S ribosomal protein L10 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00570 - sigH Type: Gene Product:RNA polymerase factor sigma-70 \| Pathway: \| COG: Transcription CD630_00530 - mrnC Type: Gene Product:Ribonuclease III \| Pathway: \| COG: Function unknown CD630_00550 - Type: Gene Product:Putative tRNA/rRNA methyltransferase, TrmHfamily, group3 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23340 - mtlA Type: Gene Product:PTS system, mannitol-specific, IICB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23320 - mtlF Type: Gene Product:PTS system, mannitol-specific, EIIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26710 - appD Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism, Inorganic ion transport and metabolism CD630_00660 - rpoB Type: Gene Product:DNA-directed RNA polymerase subunit beta \| Pathway: \| COG: Transcription CD630_26730 - appB Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_00620 - rplA Type: Gene Product:50S ribosomal protein L1 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00640 - rplL Type: Gene Product:50S ribosomal protein L7/L12 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00600 - nusG Type: Gene Product:transcription antitermination protein \| Pathway: \| COG: Transcription CD630_00581 - rpmG Type: Gene Product:50S ribosomal protein L33 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00580 - tuf1 Type: Gene Product:Elongation factor EFTu/EF1A \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00560 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00540 - thyX Type: Gene Product:Thymidylate synthase \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_00520 - cysS Type: Gene Product:Cysteinyl-tRNA synthetase (Cysteine--tRNA ligase)(CysRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23310 - mtlD Type: Gene Product:Mannitol-1-phosphate 5-dehydrogenase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26740 - appC Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism	`NA`	`NA`	0.47	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_116	6 CD630_06740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13380 - Type: Gene Product:Putative 6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07141 - Type: Gene Product:Fragment of sugar O-acetyltransferase (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_13370 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_06050 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_13370 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`