Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 101 - 110 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_5	31 CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_27290 - Type: Gene Product:Putative regulator of the sigma(E) factor \| Pathway: \| COG: Signal transduction mechanisms CD630_13020 - Type: Gene Product:Putative MazG-like pyrophosphohydrolase \| Pathway: \| COG: Function unknown CD630_10070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_08190 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_17500 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_31280 - pgmB Type: Gene Product:Beta-phosphoglucomutase (beta-D-Glucose1,6-phosphomutase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08180 - Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14310 - Type: Gene Product:Putative helicase, DinG family \| Pathway: \| COG: Replication, recombination and repair CD630_11290 - coaE Type: Gene Product:Dephospho-CoA kinase (Dephosphocoenzyme Akinase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15100 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown CD630_22530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_13990 - Type: Gene Product:putative muramoyltetrapeptide carboxypeptidase,S66 family \| Pathway: \| COG: Defense mechanisms CD630_17490 - Type: Gene Product:Putative 2-hydroxyacyl-CoA dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04870 - Type: Gene Product:Putative carbon-nitrogen hydrolase \| Pathway: \| COG: Function unknown CD630_27310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_23770 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_19450 - Type: Gene Product:Putative enzyme \| Pathway: \| COG: Amino acid transport and metabolism CD630_19430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13030 - npdA Type: Gene Product:NAD-dependent deacetylase, Sir2 family \| Pathway: \| COG: Transcription CD630_23870 - Type: Gene Product:Alpha-hydroxy acid dehydrogenase, FMN-dependent \| Pathway: \| COG: Energy production and conversion CD630_31270 - Type: Gene Product:PTS system, beta-glucoside-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14320 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Function unknown CD630_06040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17990 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_23350 - guaB Type: Gene Product:Inositol-5'-monophosphate dehydrogenase (IMPdehydrogenase) (IMPDH) (IMPD) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_22540 - Type: Gene Product:Asp/Glu racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23580 - Type: Gene Product:Oligoendopeptidase-related, clade2, M3B family \| Pathway: \| COG: Amino acid transport and metabolism CD630_20140 - ilvD Type: Gene Product:Dihydroxy-acid dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_14000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	6.2e-17	`NA`	0.45	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_05090 - Type: Gene Product:Transcriptional regulator, HTH-type Tn5397,CTn3-Orf9 \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_20920 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_394	19 CD630_11130 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf6 \| Pathway: \| COG: Function unknown CD630_22241 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: CD630_11042 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf17 \| Pathway: \| COG: Function unknown CD630_11120 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn4-Orf7 \| Pathway: \| COG: Function unknown CD630_11071 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf12 \| Pathway: \| COG: Function unknown CD630_11070 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn4-Orf13 \| Pathway: \| COG: Function unknown CD630_10540 - bcd2 Type: Gene Product:Butyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10550 - etfB Type: Gene Product:Electron transfer flavoproteins subunit beta \| Pathway: \| COG: Energy production and conversion CD630_10560 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_10580 - hbd Type: Gene Product:3-hydroxybutyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10570 - crt2 Type: Gene Product:3-hydroxybutyryl-CoA dehydratase (Crotonase) \| Pathway: \| COG: Lipid transport and metabolism CD630_10590 - thlA1 Type: Gene Product:Acetoacetyl-CoA thiolase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Lipid transport and metabolism CD630_11050 - Type: Gene Product:Putative antirestriction protein Tn1549-like,CTn4-Orf16 \| Pathway: \| COG: Function unknown CD630_11080 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf11 \| Pathway: \| COG: Function unknown CD630_11090 - Type: Gene Product:DNA-methyltransferase, cytosine-N4-specific;Tn1549-like, CTn4-Orf10 \| Pathway: \| COG: Replication, recombination and repair CD630_11110 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf8 \| Pathway: \| COG: Function unknown CD630_11061 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf14 \| Pathway: \| COG: Function unknown CD630_11060 - topB Type: Gene Product:DNA topoisomerase III; Tn1549-like, CTn4-Orf15 \| Pathway: \| COG: Replication, recombination and repair CD630_11100 - Type: Gene Product:Putative hydrolase Tn1549-like, CTn4-Orf9 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	`NA`	`NA`	0.45	Inferelator: 0 Hypergeometric: 3 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_237	20 CD630_34900 - spoIIE Type: Gene Product:Phosphoprotein phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34910 - Type: Gene Product:Putative exopolyphosphatase \| Pathway: \| COG: Nucleotide transport and metabolism, Inorganic ion transport and metabolism CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription CD630_22960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_35010 - mfd Type: Gene Product:Transcription-repair coupling factor (TRCFATP-dependent helicase mfd) \| Pathway: \| COG: Replication, recombination and repair CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_34970 - Type: Gene Product:Bifunctional protein [Includes: Tetrapyrrolemethylase; NTP pyrophosphohydrolase MazG] \| Pathway: \| COG: Function unknown CD630_34930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35000 - prsA Type: Gene Product:Peptidylprolyl isomerase PrsA-like \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35020 - pth Type: Gene Product:Peptidyl-tRNA hydrolase (PTH) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_34960 - hbs Type: Gene Product:DNA-binding protein, non-specific \| Pathway: \| COG: Replication, recombination and repair CD630_34980 - spoVB Type: Gene Product:Stage V sporulation protein B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22970 - Type: Gene Product:Putative phage-related regulatory protein \| Pathway: \| COG: Transcription CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34940 - Type: Gene Product:Putative spore protein \| Pathway: \| COG: Function unknown CD630_34920 - Type: Gene Product:Septum formation initiation protein \| Pathway: \| COG: CD630_34950 - Type: Gene Product:Putative RNA-binding S4 domain-containingprotein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_205	7 CD630_06750 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_13750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_23011 - Type: Gene Product:Fragment of putative phage protein (C-terminalregion) \| Pathway: \| COG: CD630_12382 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_13830 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_31001 - Type: Gene Product:Fragment of artefact \| Pathway: \| COG: CD630_33721 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf5 \| Pathway: \| COG:	`NA`	`NA`	0.45	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_238	9 CD630_06000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_17291 - Type: Gene Product:Fragment of putative transcriptional regulator,AraC family (C-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_22250 - Type: Gene Product:Fragment of putative integrase (N-terminalregion) \| Pathway: \| COG: Replication, recombination and repair CD630_12360 - Type: Gene Product:Fragment of putative phage protein (part 1) \| Pathway: \| COG: CD630_30200 - Type: Gene Product:Fragment of conserved hypothetical protein,DUF1848 family (Part 2) \| Pathway: \| COG: Function unknown CD630_23060 - Type: Gene Product:Fragment of putative tranposase (Central region) \| Pathway: \| COG: CD630_11140 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf5 \| Pathway: \| COG: CD630_29721 - Type: Gene Product:Fragment of conserved hypothetical protein(Central region) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_01820 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_36460 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_190	13 CD630_04280 - Type: Gene Product:Transcriptional regulator, AraC familyTn1549-like, CTn2-Orf23 \| Pathway: \| COG: Transcription CD630_04300 - Type: Gene Product:ABC-type transport system, cobalt-specificpermease Tn1549-like, CTn2-Orf25 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04290 - Type: Gene Product:Putative membrane protein Tn1549-like,CTn2-Orf24 \| Pathway: \| COG: Function unknown CD630_04310 - Type: Gene Product:ABC-type transport system, cobalt-specificATP-binding protein Tn1549-like, CTn2-Orf26 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15910 - kdpA Type: Gene Product:Potassium-translocating ATPase A chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04330 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_15930 - kdpC Type: Gene Product:Potassium-transporting ATPase C chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04260 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf21 \| Pathway: \| COG: Function unknown CD630_15920 - kdpB Type: Gene Product:Potassium-transporting ATPase B chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04340 - Type: Gene Product:Putative drug/sodium antiporter, MATE family,Tn1549-like, CTn2-Orf29 \| Pathway: \| COG: Defense mechanisms CD630_04250 - Type: Gene Product:Putative endonuclease relaxase Tn1549-like,CTn2-Orf20 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04270 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn2-Orf22 \| Pathway: \| COG: Transcription CD630_04320 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf27 \| Pathway: \| COG: Defense mechanisms	`NA`	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_319	26 CD630_27080 - aroE2 Type: Gene Product:Shikimate dehydrogenase 2 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_21991 - Type: Gene Product:Putative 4Fe-4S ferredoxin iron-sulfur bindingdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_21990 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_24280 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasebeta subunit \| Pathway: \| COG: Energy production and conversion CD630_27070 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22000 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_30970 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24250 - ptb Type: Gene Product:Phosphate butyryltransferase(Phosphotransbutyrylase) \| Pathway: \| COG: Energy production and conversion CD630_04620 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_21970 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_24270 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasegamma subunit \| Pathway: \| COG: Energy production and conversion CD630_04640 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_27090 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_24230 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21980 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_30950 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24291 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_24290 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasealpha subunit \| Pathway: \| COG: Energy production and conversion CD630_30980 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_27100 - Type: Gene Product:Putative sugar phosphate epimerase/isomerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30960 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04630 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_24240 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Transcription CD630_21960 - Type: Gene Product:Putative succinyl-CoA synthetase-like ATP-bindingprotein \| Pathway: \| COG: Energy production and conversion CD630_24260 - buk1 Type: Gene Product:Butyrate kinase 1 (BK 1) (Branched-chaincarboxylic acid kinase 1) \| Pathway: \| COG: Energy production and conversion CD630_04610 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	0.07	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_385	21 CD630_10340 - Type: Gene Product:Putative mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_02130 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31770 - Type: Gene Product:Putative xanthine dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_10310 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_02140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00340 - Type: Gene Product:Putative xylose transporter, sodium:galactosidesymporter family \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31790 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase, catalytic subunit \| Pathway: \| COG: Nucleotide transport and metabolism CD630_31170 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_10280 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_31820 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_10330 - mnaA Type: Gene Product:UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31830 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31150 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31810 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_10320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31160 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00330 - Type: Gene Product:Putative glycoside hydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00320 - Type: Gene Product:Putative beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10300 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31800 - Type: Gene Product:Putative purine permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_31780 - Type: Gene Product:D-hydantoinase (Dihydropyrimidinase) \| Pathway: \| COG: Nucleotide transport and metabolism	0.49	`NA`	0.45	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_14	28 CD630_30250 - Type: Gene Product:Putative ferredoxin, iron-sulphurdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_10770 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31320 - Type: Gene Product:PTS system, fructose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13600 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_34440 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31340 - Type: Gene Product:PTS system, fructose-like IIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34460 - Type: Gene Product:Aminopeptidase, M42 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_34420 - Type: Gene Product:Putative peptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_14150 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_10730 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_10780 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_10760 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13590 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05310 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_31350 - Type: Gene Product:Putative fructose-1-6-bisphosphate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13610 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_10740 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31310 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_34450 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19030 - Type: Gene Product:Putative lipoprotein signal peptidase \| Pathway: \| COG: Function unknown CD630_34410 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase (PLP-dependent transferase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_34470 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_34430 - Type: Gene Product:PTS system, lactose/cellobiose-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13601 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_14220 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_31330 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription	0.0000000015	0.05	0.45	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_35580 - birA Type: Gene Product:BirA bifunctional protein [Includes: biotinoperon repressor and biotin--[acetyl-CoA-carboxylase]synthetase \| Pathway: \| COG: Coenzyme transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_166	20 CD630_16830 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25590 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_16820 - iunH Type: Gene Product:Putative nucleoside hydrolase, IUNH family \| Pathway: \| COG: Nucleotide transport and metabolism CD630_11760 - Type: Gene Product:Conserved hypothetical protein, DUF177 family \| Pathway: \| COG: Function unknown CD630_25580 - coaD Type: Gene Product:Phosphopantetheine adenylyltransferase(Pantetheine-phosphate adenylyltransferase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_16840 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Function unknown CD630_04520 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25610 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_25570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11750 - ackA Type: Gene Product:Acetate kinase (Acetokinase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Energy production and conversion CD630_04530 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_20580 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04510 - Type: Gene Product:Putative dioxygenase \| Pathway: \| COG: Function unknown CD630_25600 - recG Type: Gene Product:ATP-dependent DNA helicase RecG \| Pathway: \| COG: Replication, recombination and repair CD630_20590 - glnS Type: Gene Product:Glutaminyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11761 - rpmF Type: Gene Product:50S ribosomal protein L32 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15220 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21890 - pgmB Type: Gene Product:Beta-phosphoglucomutase (beta-D-Glucose1,6-phosphomutase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21880 - mapA Type: Gene Product:Maltose phosphorylase/glycosyl hydrolase/vacuolaracid trehalase \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	2.1	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`