Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 171 - 180 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_356	31 CD630_36150 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_32350 - ssb Type: Gene Product:Single-stranded DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_12440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06920 - Type: Gene Product:Putative metallo-hydrolase/oxidoreductase \| Pathway: \| COG: Function unknown CD630_18880 - rsiU Type: Gene Product:Anti Sigma Factor, ECF family \| Pathway: \| COG: Function unknown CD630_01640 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_29510 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_10870 - zupT Type: Gene Product:Putative zinc/iron transporter, ZupT subfamiliy \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06710 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_20250 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_10850 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20190 - Type: Gene Product:Transporter drug resistance, Major FacilitatorSuperfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18900 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_10890 - rgbR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms CD630_20240 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_18840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36160 - Type: Gene Product:Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33300 - Type: Gene Product:Transcriptional regulator, HTH-type Tn916-like,CTn6-Orf6 \| Pathway: \| COG: Transcription CD630_12380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19941 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19940 - Type: Gene Product:Putative membrane protein, DUF1648 family \| Pathway: \| COG: Function unknown CD630_12430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18890 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10860 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_18830 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_18870 - csfU Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_07490 - Type: Gene Product:Putative DNA helicase, UvrD/REP type \| Pathway: \| COG: Replication, recombination and repair CD630_10880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription	6.4e-17	`NA`	0.48	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_56	21 CD630_09180 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09270 - Type: Gene Product:Putative phage DNA modification methylase \| Pathway: \| COG: Replication, recombination and repair CD630_09350 - Type: Gene Product:Putative S-adenosyl-L-methionine-dependentmethyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_09290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09170 - Type: Gene Product:Putative phage recombination protein Bet \| Pathway: \| COG: Replication, recombination and repair CD630_09300 - Type: Gene Product:Putative phage reductase \| Pathway: \| COG: Function unknown CD630_09280 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09360 - Type: Gene Product:Putative phage endodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_09370 - Type: Gene Product:Putative phage anti-repressor \| Pathway: \| COG: Transcription CD630_09210 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09301 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09120 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: CD630_09330 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09220 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09320 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09310 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	`NA`	`NA`	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_280	9 CD630_31470 - Type: Gene Product:Putative DNA-methyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_21341 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13940 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase,GFO/IDH/MOCA family \| Pathway: \| COG: Function unknown CD630_32330 - Type: Gene Product:Putative sigma-54 interacting protein \| Pathway: \| COG: Transcription CD630_17800 - Type: Gene Product:Putative methylase \| Pathway: \| COG: Replication, recombination and repair CD630_05850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21820 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_34500 - Type: Gene Product:Putative oxidoreductase with NAD(P)-bindingRossmann-fold domain \| Pathway: \| COG: Function unknown CD630_17780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_372	7 CD630_33690 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13820 - glpK2 Type: Gene Product:Glycerol kinase 1 (ATP:glycerol3-phosphotransferase 1) (Glycerokinase 1) (GK 1) \| Pathway: Polyol metabolism \| COG: Energy production and conversion CD630_22850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_24190 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_01600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_14930 - Type: Gene Product:Putative 3-methyladenine DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair	5.8	`NA`	0.40	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_18830 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_72	20 CD630_23540 - grdE Type: Gene Product:Glycine reductase complex component B subunitsalpha and beta (Selenoprotein PB alpha/beta) [Contains:Betaine reductase component B subunit beta; Betainereductase component B subunit alpha] \| Pathway: \| COG: Function unknown CD630_01170 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_r0060 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_23550 - trxA2 Type: Gene Product:Thioredoxin 2 (Trx2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23570 - grdX Type: Gene Product:Putative glycine reductase complex component \| Pathway: \| COG: Function unknown CD630_01160 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_01180 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_01740 - cooS Type: Gene Product:Carbon monoxide dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_01190 - glmM Type: Gene Product:Phosphoglucosamine mutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01150 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_01760 - Type: Gene Product:Putative oxidoreductase, NAD/FAD binding subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01130 - buk Type: Gene Product:Butyrate kinase (BK) (Branched-chain carboxylicacid kinase) \| Pathway: \| COG: Energy production and conversion CD630_01750 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_23520 - grdA Type: Gene Product:Glycine reductase complex selenoprotein A(selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_01790 - gluD Type: Gene Product:NAD-specific glutamate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23560 - trxB3 Type: Gene Product:Thioredoxin reductase 3 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01120 - ptb Type: Gene Product:phosphate butyryltransferase \| Pathway: \| COG: Energy production and conversion CD630_23510 - grdB Type: Gene Product:Glycine reductase complex component B gammasubunit (selenocysteine) \| Pathway: \| COG: Function unknown	6.7	`NA`	0.26	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_216	20 CD630_21490 - Type: Gene Product:Putative vancomycin resistance protein, vanWfamily \| Pathway: \| COG: Defense mechanisms CD630_21480 - Type: Gene Product:Putative serine/threonine protein kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23980 - Type: Gene Product:Putative 2-thiocytidine tRNA biosynthesis proteinTtcA \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_06760 - rsiT Type: Gene Product:Anti Sigma factors, ECF family \| Pathway: \| COG: Function unknown CD630_36790 - rnpA Type: Gene Product:Ribonuclease P protein component (RNaseP protein)(RNase P protein) (Protein C5) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00470 - ispD Type: Gene Product:2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_22121 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00480 - ispF Type: Gene Product:2-C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_32550 - rgaR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms CD630_23970 - Type: Gene Product:Putative exonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_36760 - mnmE Type: Gene Product:tRNA modification GTPase MnmE \| Pathway: \| COG: Function unknown CD630_36800 - rpmH Type: Gene Product:50S ribosomal protein L34 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_36780 - oxaA1 Type: Gene Product:Sporulation membrane protein SpoIIIJ \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_36781 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06770 - sigT Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_36770 - Type: Gene Product:Putative SpoIIIJ-associated RNA/ssDNA-bindingprotein Jag \| Pathway: \| COG: Function unknown CD630_19970 - Type: Gene Product:Putative proline iminopeptidase (PIP), S33family \| Pathway: \| COG: Function unknown CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_21320 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_36750 - mnmG Type: Gene Product:tRNA uridine 5-carboxymethylaminomethylmodification enzyme MnmG (Glucose-inhibited divisionprotein A) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	0	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21110 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_88	22 CD630_01380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_36470 - licA Type: Gene Product:PTS system, lichenan-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01410 - cutC Type: Gene Product:Copper homeostasis protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16080 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: CD630_01350 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01360 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26970 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_16060 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_26990 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16650 - cysM Type: Gene Product:O-acetylserine (thiol)-lyase (O-acetylserinesulfhydrylase) (OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_36480 - licB Type: Gene Product:PTS system, lichenan-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_36230 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01390 - Type: Gene Product:N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase \| Pathway: \| COG: Amino acid transport and metabolism CD630_16100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01400 - Type: Gene Product:Putative peptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_16070 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_01370 - Type: Gene Product:PTS system, lactose/cellobiose-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16640 - Type: Gene Product:Transcriptional regulator, RmlC-type \| Pathway: \| COG: Transcription CD630_36240 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown	0.03	`NA`	0.36	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04540 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_312	5 CD630_18781 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_13750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_21840 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18441 - Type: Gene Product:Fragment of putative methyltransferase(N-terminal region) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_36130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.52	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_8	19 CD630_34260 - cbiF Type: Gene Product:Cobalt-precorrin-4 C(11)-methyltransferase(Cobalt-precorrin-3 methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34190 - hemB Type: Gene Product:Delta-aminolevulinic acid dehydratase(porphobilinogen synthase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34340 - cobB Type: Gene Product:Cobyrinic acid A,C-diamide synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34270 - cbiT Type: Gene Product:Cobalt-precorrin-6Y C(15)-methyltransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34350 - cobQ Type: Gene Product:Cobyric acid synthase CobQ \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34290 - cbiD Type: Gene Product:Cobalt-precorrin-6A synthase [deacetylating] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34710 - atpH Type: Gene Product:ATP synthase subunit delta \| Pathway: \| COG: Energy production and conversion CD630_34230 - cbiJ Type: Gene Product:Cobalt-precorrin-6A reductase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34280 - cbiE Type: Gene Product:Cobalt-precorrin-6Y C(5)-methyltransferase(Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Ymethylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34250 - cbiG Type: Gene Product:Cobalamin biosynthesis protein CbiG \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34700 - atpA Type: Gene Product:ATPase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_34240 - cbiH Type: Gene Product:Cobalt-precorrin-3B C(17)-methyltransferase(Cobalt-precorrin-3 methyltransferase) (Cobalt-precorrin-3methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34210 - hemC Type: Gene Product:Porphobilinogen deaminase (PBG)(Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogensynthase) \| Pathway: Porphyrin-containing compound metabolism \| COG: Coenzyme transport and metabolism CD630_34200 - cobA + hemD Type: Gene Product:Bifunctional uroporphyrinogen-IIImethyltransferase/uroporphyrinogen-III synthase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34220 - cbiK Type: Gene Product:Sirohydrochlorin cobaltochelatase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34730 - atpE Type: Gene Product:ATP synthase subunit c \| Pathway: \| COG: Energy production and conversion CD630_34690 - atpG Type: Gene Product:ATP synthase gamma chain \| Pathway: \| COG: Energy production and conversion CD630_34300 - cbiC Type: Gene Product:Cobalt-precorrin-8X methylmutase(Cobalt-precorrin isomerase) (HBA synthase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34680 - atpD Type: Gene Product:ATP synthase subunit beta \| Pathway: \| COG: Energy production and conversion	`NA`	`NA`	0.31	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_24	20 CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_30850 - mngB Type: Gene Product:Alpha-mannosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05820 - Type: Gene Product:Putative pyruvate phosphate dikinase,PEP/pyruvate-binding \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30320 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_31650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_31670 - Type: Gene Product:Putative phosphatidylethanolamine-bindingregulatory protein \| Pathway: \| COG: Function unknown CD630_03030 - argE Type: Gene Product:Acetylornithine deacetylase ArgE \| Pathway: \| COG: Amino acid transport and metabolism CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_t0450 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_30860 - mngA Type: Gene Product:PTS system, 2-O-a-mannosyl-D-glycerate-specificIIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05810 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_03040 - Type: Gene Product:Conserved hypothetical protein, DUF1355 family \| Pathway: \| COG: Function unknown CD630_05900 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23861 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription	0.000009	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`