Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 21 - 30 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_18	20 CD630_06890 - Type: Gene Product:Putative nucleotide phosphodiesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19870 - cwp28 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_03910 - asnB Type: Gene Product:Asparagine synthetase [glutamine-hydrolyzing] \| Pathway: \| COG: Amino acid transport and metabolism CD630_32300 - bclA2 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Function unknown CD630_15951 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_07960 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24411 - Type: Gene Product:PhoH-like protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32310 - hpt Type: Gene Product:Hypoxanthine phosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_31590 - Type: Gene Product:Putative FemA-like peptidoglycan biosynthesisprotein \| Pathway: \| COG: Function unknown CD630_21520 - Type: Gene Product:Putative glutamyl-aminopeptidase, M42 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_25370 - Type: Gene Product:Putative membrane-associated5'-nucleotidase/phosphoesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_12590 - brnQ-1 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27990 - cwp8 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.00000000000017	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_120	7 CD630_28860 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_32340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32330 - Type: Gene Product:Putative sigma-54 interacting protein \| Pathway: \| COG: Transcription CD630_20090 - Type: Gene Product:Fragment of putative topoisomerase (C-terminalregion) \| Pathway: \| COG: Replication, recombination and repair CD630_27000 - Type: Gene Product:Transcriptional regulator, sigma-54 dependent \| Pathway: \| COG: Transcription CD630_21030 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_28410 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_20400 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_284	21 CD630_17730 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06900 - Type: Gene Product:Putative nucleotide phosphodiesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_14750 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_27920 - secA2 Type: Gene Product:Protein translocase secA 2 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_02100 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIA \| Pathway: \| COG: Function unknown CD630_06910 - Type: Gene Product:Putative short chain dehydrogenase/reductase, SDRfamily \| Pathway: \| COG: Function unknown CD630_01680 - Type: Gene Product:Putative cyclic nucleotide-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_07060 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_03181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10030 - fumA Type: Gene Product:Fumarate hydratase class I, subunit A \| Pathway: \| COG: Energy production and conversion CD630_27060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27960 - cwp10 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33190 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_06600 - tcdB Type: Gene Product:Toxin B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20520 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_10050 - Type: Gene Product:Putative NAD-dependent malic enzyme \| Pathway: \| COG: Energy production and conversion CD630_10040 - fumB Type: Gene Product:Fumarate hydratase class I, subunit B \| Pathway: \| COG: Energy production and conversion CD630_11000 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn4-Orf24 \| Pathway: \| COG: Transcription CD630_30620 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription	0.0000000000000035	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_349	29 CD630_18360 - pheA Type: Gene Product:Bifunctional P-protein, chorismatemutase/prephenate dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_18340 - aroA Type: Gene Product:3-phosphoshikimate 1-carboxyvinyltransferase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_18380 - aroK Type: Gene Product:Shikimate kinase (SK) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_11890 - Type: Gene Product:Putative amino acid/polyamine transporter I \| Pathway: \| COG: Amino acid transport and metabolism CD630_13180 - pnp Type: Gene Product:Polyribonucleotide nucleotidyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18390 - tyrC Type: Gene Product:Prephenate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_22040 - Type: Gene Product:Putative esterase \| Pathway: \| COG: Function unknown CD630_35760 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22060 - aldH Type: Gene Product:Aldehyde dehydrogenase (aldehyde:NAD+oxidoreductase) \| Pathway: \| COG: Energy production and conversion CD630_18330 - aroB Type: Gene Product:3-dehydroquinate synthase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_11761 - rpmF Type: Gene Product:50S ribosomal protein L32 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11760 - Type: Gene Product:Conserved hypothetical protein, DUF177 family \| Pathway: \| COG: Function unknown CD630_13170 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18350 - aroC Type: Gene Product:Chorismate synthase(5-enolpyruvylshikimate-3-phosphate phospholyase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_11880 - Type: Gene Product:Putative gamma-glutamyl-gamma-aminobutyratehydrolase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_18370 - aroE1 Type: Gene Product:Shikimate dehydrogenase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_01790 - gluD Type: Gene Product:NAD-specific glutamate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33930 - rumA Type: Gene Product:23S rRNA (uracil-5-)-methyltransferase RumA (23SrRNA(M-5-U1939)-methyltransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17850 - argG Type: Gene Product:Argininosuccinate synthase (Citrulline--aspartateligase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_35750 - Type: Gene Product:Putative sodium:solute symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_35730 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13410 - exoA Type: Gene Product:Exodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_35770 - mdeA Type: Gene Product:methionine gamma-lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25030 - Type: Gene Product:Putative cation-transporting P-type ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15230 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Function unknown CD630_22050 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18320 - aroF Type: Gene Product:3-deoxy-D-arabino-heptulosonate 7-phosphatesynthase \| Pathway: \| COG: Amino acid transport and metabolism	0.0000000079	`NA`	0.63	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_334	6 CD630_06740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09780 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: CD630_18441 - Type: Gene Product:Fragment of putative methyltransferase(N-terminal region) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17591 - Type: Gene Product:Fragment of conserved hypothetical protein,UPF0027 family (C-terminal region) \| Pathway: \| COG: CD630_01960 - Type: Gene Product:Fragment of conserved hypothetical protein,DUF111 family (Part 1) \| Pathway: \| COG: Function unknown, Function unknown	`NA`	`NA`	0.63	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_352	22 CD630_31201 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14780 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29101 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_14800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29160 - Type: Gene Product:Putative phage major capsid protein \| Pathway: \| COG: Function unknown CD630_02820 - Type: Gene Product:Putative PHP hydrolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_31680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_05910 - Type: Gene Product:Putative ATPase, P-type, heavy metaltranslocating \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12870 - fur Type: Gene Product:Transcriptional regulator, Fur family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31210 - Type: Gene Product:Putative flavodoxin/nitric oxide synthase \| Pathway: \| COG: Energy production and conversion CD630_23960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30360 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_36370 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_14790 - feoB1 Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13360 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02830 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_06360 - Type: Gene Product:Putative radical SAM superfamily protein, DUF85family \| Pathway: \| COG: Replication, recombination and repair CD630_14770 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29080 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000014	0.01	0.63	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_209	15 CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_36050 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_13530 - Type: Gene Product:Putative phosphomethylpyrimidine kinase \| Pathway: Cofactor metabolism \| COG: Coenzyme transport and metabolism CD630_36040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_14420 - Type: Gene Product:Putative MORN repeat-containing protein \| Pathway: \| COG: Function unknown CD630_14830 - ssuB Type: Gene Product:ABC-type transport system, sulfonates-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24461 - rpsU Type: Gene Product:30S ribosomal protein S21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14840 - ssuA Type: Gene Product:ABC-type transport system,alkanesulfonates-family extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14810 - Type: Gene Product:Putative tryptophan RNA-binding attenuationprotein \| Pathway: \| COG: Signal transduction mechanisms CD630_14820 - ssuC Type: Gene Product:ABC-type transport system, sulfonates-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36030 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown	0	`NA`	0.63	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_369	27 CD630_08950 - Type: Gene Product:Metallo-beta-lactamase superfamily exportedprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24750 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_15951 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_06960 - Type: Gene Product:Putative cation transport protein, Trk family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31060 - Type: Gene Product:Transaldolase \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_27620 - uppS Type: Gene Product:Putative undecaprenyl pyrophosphate synthetase \| Pathway: \| COG: Lipid transport and metabolism CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_06560 - Type: Gene Product:Chloride ion channel protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11690 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_05200 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_08960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26560 - spoVD Type: Gene Product:Stage V sporulation protein D(Sporulation-specific penicillin-binding protein) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01950 - Type: Gene Product:Putative NCAIR-mutase (PurE)-related protein \| Pathway: \| COG: Function unknown CD630_36460 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_24740 - Type: Gene Product:Putative DNA polymerase III, delta subunit \| Pathway: \| COG: Replication, recombination and repair CD630_06970 - Type: Gene Product:Putative regulator of K+ conductance \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31070 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_06570 - cdu2 Type: Gene Product:Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05210 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_26570 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_04890 - Type: Gene Product:Putativephosphoribosylaminoimidazole-succinocarboxamide synthetase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_11680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33682 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19900 - Type: Gene Product:Putative protein with SH3 domain \| Pathway: \| COG: Function unknown CD630_19903 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27630 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_23090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	9.9e-23	0.0000000000019	0.63	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_66	24 CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_29870 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_15990 - thiD Type: Gene Product:Phosphomethylpyrimidine kinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_29840 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_29860 - uppP2 Type: Gene Product:Undecaprenyl-diphosphatase 2 (Undecaprenylpyrophosphate phosphatase 2) (Bacitracin resistance protein2) \| Pathway: \| COG: Defense mechanisms CD630_14880 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_16000 - thiM Type: Gene Product:Hydroxyethylthiazole kinase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_32660 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22430 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09040 - Type: Gene Product:Putative phage integrase \| Pathway: \| COG: Replication, recombination and repair CD630_32070 - Type: Gene Product:Putative multi antimicrobial extrusion protein,MatE family \| Pathway: \| COG: Defense mechanisms CD630_29880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_21130 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_29850 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_14870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14180 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_15420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15390 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16010 - thiE Type: Gene Product:Thiamine-phosphate pyrophosphorylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_32650 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_32670 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_33600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	0.000000000027	0.04	0.62	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_371	26 CD630_19400 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19401 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_28490 - phnXW Type: Gene Product:Bifunctional phosphonoacetaldehydehydrolase/aminoethylphosphonate transaminase [Includes:Phosphonoacetaldehyde hydrolase ;2-aminoethylphosphonate--pyruvate transaminase] \| Pathway: \| COG: Amino acid transport and metabolism CD630_00130 - Type: Gene Product:Putative mechanosensitive ion channel protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10521 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19600 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_29530 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19620 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_23861 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01570 - Type: Gene Product:Fragment of putative membrane protein (Part 2) \| Pathway: \| COG: Function unknown CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09080 - Type: Gene Product:Putative antirepressor protein \| Pathway: \| COG: Transcription CD630_02000 - Type: Gene Product:Fragment of transcriptional regulator, LysRfamily (C-terminal region) \| Pathway: \| COG: Transcription CD630_00120 - Type: Gene Product:Putative small-molecule-binding protein \| Pathway: \| COG: Transcription CD630_t0830 - tRNA-Thr Type: Gene Product: \| Pathway: \| COG: CD630_05780 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19610 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_05790 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_r0090 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_09071 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_01811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04341 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf30 \| Pathway: \| COG: CD630_t0800 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_09090 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	0.00000000000058	0.000000016	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19010 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`