Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 21 - 30 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_117	27 CD630_01920 - cls Type: Gene Product:Cardiolipin synthetase 1 \| Pathway: \| COG: Lipid transport and metabolism CD630_22870 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_30440 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_12630 - Type: Gene Product:Putative FMN-dependent dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_24750 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12610 - Type: Gene Product:Putative ribonucleotide-diphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_24770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10130 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_24780 - Type: Gene Product:Putative DNA uptake transporter \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25710 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_34120 - uvrB Type: Gene Product:Excinuclease ABC subunit B \| Pathway: \| COG: Replication, recombination and repair CD630_34100 - uvrC Type: Gene Product:Excinuclease ABC subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_30450 - Type: Gene Product:Putative ATPase, BadF/BadG/BcrA/BcrD type \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34090 - hprK Type: Gene Product:PTS system, HPr kinase/phosphorylase \| Pathway: \| COG: Signal transduction mechanisms CD630_32170 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_22860 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_12620 - rnhB Type: Gene Product:Ribonuclease HII (RNase HII) \| Pathway: \| COG: Replication, recombination and repair CD630_24740 - Type: Gene Product:Putative DNA polymerase III, delta subunit \| Pathway: \| COG: Replication, recombination and repair CD630_25240 - nadD Type: Gene Product:Nicotinate-nucleotide adenylyltransferase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_01910 - Type: Gene Product:Putative DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_24760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10140 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_12640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_34110 - uvrA Type: Gene Product:Excinuclease ABC subunit A \| Pathway: \| COG: Replication, recombination and repair CD630_25230 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Coenzyme transport and metabolism	0.04	`NA`	0.59	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_118	24 CD630_17640 - Type: Gene Product:Putative phenylalanyl-tRNA synthetase beta chain \| Pathway: \| COG: Function unknown CD630_17700 - ogt2 Type: Gene Product:Methylated-DNA-[protein]-cysteineS-methyltransferase 2 \| Pathway: \| COG: Replication, recombination and repair CD630_10620 - acpP Type: Gene Product:Acyl carrier protein (ACP) \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_15970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27910 - cwp2 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23690 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25490 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24560 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17630 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_14030 - Type: Gene Product:Putative synthetase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14010 - Type: Gene Product:Putative isochorismatase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_17710 - Type: Gene Product:Putative monooxygenase \| Pathway: \| COG: Function unknown CD630_27980 - cwp9 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17650 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_10630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27900 - Type: Gene Product:Putative LmbE-like deacetylase \| Pathway: \| COG: Function unknown CD630_10840 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease protein \| Pathway: \| COG: Defense mechanisms CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms CD630_24570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_25480 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27890 - cwp66 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25500 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism	0.00000000000023	0.06	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_119	25 CD630_33170 - fdhF Type: Gene Product:Formate dehydrogenase-H (selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_21230 - Type: Gene Product:Putative multiprotein-complex assembly TPRrepeat-containing protein \| Pathway: \| COG: Function unknown CD630_18220 - bcp Type: Gene Product:Putative thiol peroxidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_12350 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_11910 - fbp Type: Gene Product:Fructose-1,6-bisphosphatase \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_15760 - Type: Gene Product:Putative esterase, SGNH hydrolase-type \| Pathway: \| COG: Amino acid transport and metabolism CD630_28140 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_21240 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown CD630_14130 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_14110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33160 - fdhD Type: Gene Product:Formate dehydrogenase formation protein \| Pathway: \| COG: Energy production and conversion CD630_33140 - hydA Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_18230 - Type: Gene Product:Conserved hypothetical protein, UPF0246 family \| Pathway: \| COG: Replication, recombination and repair CD630_19942 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15770 - pgm Type: Gene Product:Alpha-phosphoglucomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02950 - Type: Gene Product:Putative iron-sulfur-binding protein \| Pathway: \| COG: Energy production and conversion CD630_02960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11900 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_18240 - Type: Gene Product:P-type calcium transport ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33150 - hydN2 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_33151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33130 - hydN1 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion	0.00000044	0.000016	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_12	20 CD630_33220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19870 - cwp28 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_30050 - Type: Gene Product:Transcriptional regulator, IclR family \| Pathway: \| COG: Transcription CD630_05110 - tndX Type: Gene Product:Recombinase site-specific resolvase familyTn5397, CTn3-Orf3 \| Pathway: \| COG: Replication, recombination and repair CD630_33660 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_15670 - cotG Type: Gene Product:Putative spore-associated manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_32680 - pstS Type: Gene Product:ABC-type transport system, phosphateextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17400 - Type: Gene Product:Glycine/sarcosine/betaine reductase complex,protein B, alpha and beta subunits \| Pathway: \| COG: Function unknown CD630_32480 - Type: Gene Product:Polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10290 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_01640 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19890 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_33210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05270 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_07410 - glpK1 Type: Gene Product:Glycerol kinase (GK) \| Pathway: Polyol metabolism \| COG: Energy production and conversion CD630_12400 - vanZ Type: Gene Product:Teicoplanin resistance protein \| Pathway: \| COG: Defense mechanisms CD630_32500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12590 - brnQ-1 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism	5.7e-17	`NA`	0.48	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_120	7 CD630_28860 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_32340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32330 - Type: Gene Product:Putative sigma-54 interacting protein \| Pathway: \| COG: Transcription CD630_20090 - Type: Gene Product:Fragment of putative topoisomerase (C-terminalregion) \| Pathway: \| COG: Replication, recombination and repair CD630_27000 - Type: Gene Product:Transcriptional regulator, sigma-54 dependent \| Pathway: \| COG: Transcription CD630_21030 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_28410 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_20400 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_121	20 CD630_27720 - tuaG Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27730 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15570 - Type: Gene Product:Putative peptidylprolyl isomerase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27710 - rkpK Type: Gene Product:UDP-glucose 6-dehydrogenase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27750 - Type: Gene Product:Putative glycerophosphotransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15560 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27760 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15590 - rsiV Type: Gene Product:Anti Sigma Factor, ECF family \| Pathway: \| COG: Function unknown CD630_27740 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27800 - pgm Type: Gene Product:Alpha-phosphoglucomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15610 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27780 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15580 - sigV Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_15600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27690 - Type: Gene Product:Putative polysaccharide biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27700 - Type: Gene Product:Putative glycosyl transferase, group 1 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27820 - cwp7 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27790 - manC Type: Gene Product:Putative mannose-1-phosphate guanylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.40	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_10230 - Type: Gene Product:Putative transcriptional regulator, HTH \| Pathway: \| COG: Transcription CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_122	25 CD630_18300 - kdpE Type: Gene Product:Two-component response regulator KdpE \| Pathway: \| COG: Signal transduction mechanisms CD630_t0010 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_17220 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: CD630_07470 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_06420 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_t0650 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_06400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07460 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_18290 - kdpD Type: Gene Product:Two-component sensor histidine kinase KdpD \| Pathway: \| COG: Signal transduction mechanisms CD630_08390 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06271 - Type: Gene Product:Putative ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_07480 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32050 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_08380 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: CD630_t0690 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_06280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_17210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17230 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_06410 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_05870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32060 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_25621 - rpmB Type: Gene Product:50S ribosomal protein L28 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33722 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf6 \| Pathway: \| COG: Function unknown CD630_12331 - Type: Gene Product:Fragment of phage protein \| Pathway: \| COG:	4.1e-20	0.0000000000035	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_22150 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_123	22 CD630_05880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20290 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_14960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_12400 - vanZ Type: Gene Product:Teicoplanin resistance protein \| Pathway: \| COG: Defense mechanisms CD630_15450 - Type: Gene Product:Conserved hypothetical protein, DUF1836 family \| Pathway: \| COG: Function unknown CD630_26870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08920 - cspA Type: Gene Product:Cold shock protein \| Pathway: \| COG: Transcription CD630_35170 - purR Type: Gene Product:Transcriptional regulator, Purine operonrepressor \| Pathway: \| COG: Transcription CD630_05870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21261 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06060 - Type: Gene Product:Fragment of chloride ion channel protein (part1) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20720 - Type: Gene Product:Putative transposase \| Pathway: \| COG: Replication, recombination and repair CD630_35180 - murC Type: Gene Product:UDP-N-acetylmuramate--L-alanine ligase(UDP-N-acetylmuramoyl-L-alanine synthetase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_15460 - Type: Gene Product:Putative channel-forming hemolysin \| Pathway: \| COG: Function unknown CD630_13550 - cspB Type: Gene Product:Cold shock protein CspB \| Pathway: \| COG: Transcription CD630_26840 - Type: Gene Product:Putative flavodoxin-related protein \| Pathway: \| COG: Function unknown CD630_26860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_07250 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit delta \| Pathway: \| COG: Energy production and conversion	0.000000000000032	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_124	25 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_17260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_06370 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_15080 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_08820 - glgC Type: Gene Product:Glucose-1-phosphate adenylyltransferase \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_22490 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000067	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_125	26 CD630_31461 - Type: Gene Product:Fragment of putative transposase, IS4 family(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_31563 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27810 - mviN Type: Gene Product:Cell well glycopolymers exporter, flipase-type \| Pathway: Cell wall biogenesis \| COG: Signal transduction mechanisms CD630_27830 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_15700 - Type: Gene Product:Putative lysophospholipase (Disrupted by IStron) \| Pathway: \| COG: Lipid transport and metabolism, Lipid transport and metabolism CD630_05071 - Type: Gene Product:Fragment of Tet(M) leader peptide Tn5397,CTn3-orf12 (C-terminal region) \| Pathway: \| COG: CD630_12980 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19990 - fldX Type: Gene Product:Flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_31531 - Type: Gene Product:Fragment of putative phage protein (N-terminalregion) \| Pathway: \| COG: Function unknown CD630_22600 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_27700 - Type: Gene Product:Putative glycosyl transferase, group 1 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_19020 - Type: Gene Product:Fragment of putative conjugative transposonprotein (Central region) \| Pathway: \| COG: Replication, recombination and repair CD630_32170 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_20052 - Type: Gene Product:Fragment of conserved hypothetical protein(Central region) \| Pathway: \| COG: Function unknown CD630_11660 - hom1 Type: Gene Product:Homoserine dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_34532 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17511 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22980 - srl Type: Gene Product:Actin aggregate factor \| Pathway: \| COG: CD630_18782 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf39 \| Pathway: \| COG: Function unknown CD630_06511 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33781 - Type: Gene Product:Fragment of putative transcriptional regulatorTn916-like, CTn7-Orf14 (Central region) \| Pathway: \| COG: Transcription CD630_31381 - Type: Gene Product:Fragment of putative phage transcriptionalregulator (C-terminal region) \| Pathway: \| COG: CD630_01981 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15350 - sseA Type: Gene Product:3-mercaptopyruvate sulfurtransferase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_t0870 - tRNA-Lys Type: Gene Product: \| Pathway: \| COG:	0.00000027	`NA`	0.56	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`