Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 201 - 210 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_28	16 CD630_00780 - rplV Type: Gene Product:50S ribosomal protein L22 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00870 - rplR Type: Gene Product:50S ribosomal protein L18 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00730 - rplC Type: Gene Product:50S ribosomal protein L3 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00790 - rpsC Type: Gene Product:30S ribosomal protein S3 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00890 - rplO Type: Gene Product:50S ribosomal protein L15 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00950 - rpsM Type: Gene Product:30S ribosomal protein S13 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00940 - infA Type: Gene Product:Translation initiation factor IF-1 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00740 - rplD Type: Gene Product:50S ribosomal protein L4 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00900 - prlA Type: Gene Product:Preprotein translocase SecY subunit \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_01040 - rplM Type: Gene Product:50S ribosomal protein L13 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00770 - rpsS Type: Gene Product:30S ribosomal protein S19 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00700 - fusA Type: Gene Product:Elongation factor G (EF-G) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00920 - map1 Type: Gene Product:Methionine aminopeptidase Map1 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00910 - adk Type: Gene Product:Adenylate kinase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_00820 - rplN Type: Gene Product:50S ribosomal protein L14 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00930 - Type: Gene Product:Ribosomal protein L14E/L6E/L27E-like \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.12	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_280	9 CD630_31470 - Type: Gene Product:Putative DNA-methyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_21341 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13940 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase,GFO/IDH/MOCA family \| Pathway: \| COG: Function unknown CD630_32330 - Type: Gene Product:Putative sigma-54 interacting protein \| Pathway: \| COG: Transcription CD630_17800 - Type: Gene Product:Putative methylase \| Pathway: \| COG: Replication, recombination and repair CD630_05850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21820 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_34500 - Type: Gene Product:Putative oxidoreductase with NAD(P)-bindingRossmann-fold domain \| Pathway: \| COG: Function unknown CD630_17780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_281	27 CD630_20430 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_09290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29120 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09300 - Type: Gene Product:Putative phage reductase \| Pathway: \| COG: Function unknown CD630_09301 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09360 - Type: Gene Product:Putative phage endodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_06110 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09320 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_04950 - Type: Gene Product:Fragment of putative regulatory protein (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_18120 - Type: Gene Product:Fragment of putative two-component responseregulator (N-terminal region) \| Pathway: \| COG: CD630_09380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09280 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_22190 - Type: Gene Product:Fragment of conjugative transposon protein(central region) \| Pathway: \| COG: Function unknown CD630_29150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09350 - Type: Gene Product:Putative S-adenosyl-L-methionine-dependentmethyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_09270 - Type: Gene Product:Putative phage DNA modification methylase \| Pathway: \| COG: Replication, recombination and repair CD630_06100 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23051 - Type: Gene Product:Fragment of transposase (N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_09250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09370 - Type: Gene Product:Putative phage anti-repressor \| Pathway: \| COG: Transcription CD630_09330 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09310 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28390 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	4.1	`NA`	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_282	26 CD630_28500 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_36190 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_33190 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_t0660 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_32640 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_16020 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_21030 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_14130 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_22160 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26960 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_01670 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_t0460 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_15190 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Function unknown CD630_08980 - Type: Gene Product:Conserved hypothetical protein, DUF1846-family \| Pathway: \| COG: Function unknown CD630_08970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16200 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_28790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28550 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_19420 - trmB Type: Gene Product:tRNA (guanine-N(7)-)-methyltransferase(tRNA(m7G46)-methyltransferase) \| Pathway: tRNA modification \| COG: Energy production and conversion	0.0000016	0.02	0.62	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_283	10 CD630_13970 - Type: Gene Product:Conserved hypothetical protein, UPF0066 family \| Pathway: \| COG: Function unknown CD630_16510 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_27110 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_27360 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_21220 - Type: Gene Product:Putative cations transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13980 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_09970 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18782 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf39 \| Pathway: \| COG: Function unknown CD630_16600 - Type: Gene Product:Conserved hypothetical protein, DUF 1255 family \| Pathway: \| COG: Function unknown	0.85	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_284	21 CD630_17730 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06900 - Type: Gene Product:Putative nucleotide phosphodiesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_14750 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_27920 - secA2 Type: Gene Product:Protein translocase secA 2 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_02100 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIA \| Pathway: \| COG: Function unknown CD630_06910 - Type: Gene Product:Putative short chain dehydrogenase/reductase, SDRfamily \| Pathway: \| COG: Function unknown CD630_01680 - Type: Gene Product:Putative cyclic nucleotide-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_07060 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_03181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10030 - fumA Type: Gene Product:Fumarate hydratase class I, subunit A \| Pathway: \| COG: Energy production and conversion CD630_27060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27960 - cwp10 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33190 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_06600 - tcdB Type: Gene Product:Toxin B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20520 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_10050 - Type: Gene Product:Putative NAD-dependent malic enzyme \| Pathway: \| COG: Energy production and conversion CD630_10040 - fumB Type: Gene Product:Fumarate hydratase class I, subunit B \| Pathway: \| COG: Energy production and conversion CD630_11000 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn4-Orf24 \| Pathway: \| COG: Transcription CD630_30620 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription	0.0000000000000035	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_285	23 CD630_13480 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_29410 - Type: Gene Product:Putative phage single-strand DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_13310 - sip3 Type: Gene Product:Signal peptidase I, S26A family \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_29900 - ssuB2 Type: Gene Product:ABC-type transport system, sulfonate-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13330 - Type: Gene Product:Putative phage tyrosine recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_29920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13440 - Type: Gene Product:Putative cell wall biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13460 - Type: Gene Product:Conserved hypothetical protein, DUF1700 \| Pathway: \| COG: Function unknown CD630_13500 - cprB Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_13520 - cprK Type: Gene Product:Two-component sensor histidine kinase, cationicantimicrobial peptide resistance \| Pathway: \| COG: Signal transduction mechanisms CD630_32480 - Type: Gene Product:Polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15300 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_13340 - purB Type: Gene Product:Adenylosuccinate lyase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_29910 - ssuC2 Type: Gene Product:ABC-type transport system, sulfonate-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13490 - cprA Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_13450 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_13320 - uppP1 Type: Gene Product:Undecaprenyl-diphosphatase 1 (Undecaprenylpyrophosphate phosphatase 1) (Bacitracin resistance protein1) \| Pathway: \| COG: Defense mechanisms CD630_13470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13510 - cprC Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_32490 - sspB Type: Gene Product:Small, acid-soluble spore protein beta \| Pathway: \| COG: Function unknown CD630_29890 - ssuA2 Type: Gene Product:ABC-type transport system, sulfonate-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25250 - recX Type: Gene Product:Regulatory protein RecX \| Pathway: \| COG: Function unknown	0.00000019	0.0000097	0.58	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_286	27 CD630_22860 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_22870 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_33870 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf24 \| Pathway: \| COG: Function unknown CD630_25680 - Type: Gene Product:PTS system, mannose-specfic IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_12350 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_16270 - vanY Type: Gene Product:D-alanyl-D-alanine carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_r0090 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_02430 - Type: Gene Product:Methyltransferase \| Pathway: \| COG: Function unknown CD630_05240 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_25650 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Transcription CD630_25670 - Type: Gene Product:PTS system, mannose-specfic IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25201 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal part) \| Pathway: \| COG: CD630_17860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31531 - Type: Gene Product:Fragment of putative phage protein (N-terminalregion) \| Pathway: \| COG: Function unknown CD630_30630 - Type: Gene Product:Putative peptidase, S41 family \| Pathway: \| COG: Function unknown CD630_r0310 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_33871 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf25 \| Pathway: \| COG: Function unknown CD630_13010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_21220 - Type: Gene Product:Putative cations transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14180 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_15831 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16260 - vanG Type: Gene Product:D-alanine--D-alanine ligase 2 \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_25660 - Type: Gene Product:PTS system, mannose-specfic IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16280 - vanT Type: Gene Product:Alanine racemase 1 \| Pathway: Amino-acid biosynthesis \| COG: Cell wall/membrane/envelope biogenesis	0	0.57	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22150 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_287	23 CD630_26550 - murF Type: Gene Product:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase)(D-alanyl-D-alanine-adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33310 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf7 \| Pathway: \| COG: Function unknown CD630_26470 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_26490 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14640 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_07460 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_14660 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_11850 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_31680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_26520 - spoVE Type: Gene Product:Cell division/stage V sporulation protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_07480 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26500 - Type: Gene Product:Putative cell division protein Fts-Q type \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26540 - mraY Type: Gene Product:Phospho-N-acetylmuramoyl-pentapeptide-transferase(UDP- MurNAc-pentapeptide phosphotransferase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33320 - Type: Gene Product:Transcriptional regulator, TetR family;Tn916-like, CTn6-Orf8 \| Pathway: \| COG: Transcription CD630_26480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07470 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_14650 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_11860 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_14670 - Type: Gene Product:ABC-type transport system, permease protein \| Pathway: \| COG: Defense mechanisms CD630_31690 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown CD630_26530 - murD Type: Gene Product:UDP-N-acetylmuramoylalanine--D-glutamate ligase(UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase)(D-glutamic acid- adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33330 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf9 \| Pathway: \| COG: Transcription CD630_26510 - murG Type: Gene Product:UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosaminetransferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis	0.13	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_288	21 CD630_12080 - Type: Gene Product:Putative RNA-binding S4-domain protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12050 - ispA Type: Gene Product:Geranyltranstransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_12060 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25560 - Type: Gene Product:PTS system, fructose/mannitol-family IIABcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_12090 - recN Type: Gene Product:DNA repair protein RecN (Recombination proteinN) \| Pathway: \| COG: Replication, recombination and repair CD630_11960 - spoIIIAE Type: Gene Product:Stage III sporulation protein AE \| Pathway: \| COG: Function unknown CD630_23290 - tal Type: Gene Product:Transaldolase \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_23170 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23300 - xpt Type: Gene Product:Xanthine phosphoribosyltransferase (XPRTase) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25930 - Type: Gene Product:ABC-type transport system,pristinamycin/multidrug-family ATP-binding protein \| Pathway: \| COG: Function unknown CD630_25550 - Type: Gene Product:PTS system, fructose/mannitol-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23160 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_12020 - gcp Type: Gene Product:O-sialoglycoprotein endopeptidase, peptidase M22family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12070 - dxs Type: Gene Product:1-deoxy-D-xylulose-5-phosphate synthase \| Pathway: Metabolic intermediate biosynthesis \| COG: Coenzyme transport and metabolism CD630_12000 - Type: Gene Product:Conserved hypothetical protein, DUF322 familly \| Pathway: \| COG: Function unknown CD630_06271 - Type: Gene Product:Putative ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_24720 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Function unknown CD630_12030 - xseA Type: Gene Product:Exodeoxyribonuclease 7 large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_06280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12010 - nusB Type: Gene Product:N utilization substance protein B homolog(Protein NusB) \| Pathway: \| COG: Transcription	0.05	0.18	0.64	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`