Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 321 - 330 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_96	6 CD630_12870 - fur Type: Gene Product:Transcriptional regulator, Fur family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31470 - Type: Gene Product:Putative DNA-methyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_36340 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_09740 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29640 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_05320 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription	`NA`	`NA`	0.57	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_05320 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_12870 - fur Type: Gene Product:Transcriptional regulator, Fur family \| Pathway: \| COG: Inorganic ion transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_374	20 CD630_15500 - hisB Type: Gene Product:Imidazoleglycerol-phosphate dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_32690 - Type: Gene Product:Putative oligoendopeptidase F, M3B family \| Pathway: \| COG: Amino acid transport and metabolism CD630_10370 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15530 - hisF Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisF \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15480 - hisG Type: Gene Product:ATP phosphoribosyltransferase (ATP-PRTase)(ATP-PRT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10430 - sbcC Type: Gene Product:Nuclease SbcCD subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_15520 - hisA Type: Gene Product:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_32700 - Type: Gene Product:Putative magnesium transport ATPase, MgtC/SapBfamily \| Pathway: \| COG: Function unknown CD630_15470 - hisZ Type: Gene Product:ATP phosphoribosyltransferase regulatory subunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_15490 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase (Imidazoleacetol-phosphate transaminase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10410 - addA Type: Gene Product:ATP-dependent nuclease subunit A (ATP-dependenthelicase addA) \| Pathway: \| COG: Replication, recombination and repair CD630_21430 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_10400 - addB Type: Gene Product:ATP-dependent nuclease subunit B (ATP-dependenthelicase addB), Superfamily 1 UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_10380 - Type: Gene Product:Putative helicase, superfamily 1, UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_10420 - sbcD Type: Gene Product:Nuclease SbcCD subunit D \| Pathway: \| COG: Replication, recombination and repair CD630_10390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15540 - hisI Type: Gene Product:Histidine biosynthesis bifunctional protein HisIE[Includes: Phosphoribosyl-AMP cyclohydrolase ;Phosphoribosyl-ATP pyrophosphatase] \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15510 - hisH Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisH \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_21440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20020 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription	0.76	`NA`	0.57	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_21430 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_241	32 CD630_14860 - Type: Gene Product:Putative ribosome recycling factor \| Pathway: \| COG: CD630_20000 - isp Type: Gene Product:Intracellular serine protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_20432 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23030 - Type: Gene Product:Fragment of putative phage transcriptionalrepressor (N-terminal region) \| Pathway: \| COG: Transcription CD630_01721 - fdxA Type: Gene Product:Ferredoxin (4Fe-4S cluster-containing protein)(fdx-like) \| Pathway: \| COG: Energy production and conversion CD630_06920 - Type: Gene Product:Putative metallo-hydrolase/oxidoreductase \| Pathway: \| COG: Function unknown CD630_14370 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (N-terminal region) \| Pathway: \| COG: Transcription CD630_28450 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_07540 - thiI Type: Gene Product:Thiamine biosynthesis protein ThiI \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_21420 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_07560 - Type: Gene Product:Nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_22460 - cspC Type: Gene Product:Germination- specific protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_31840 - dpaL Type: Gene Product:Diaminopropionate ammonia-lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_34540 - Type: Gene Product:Putative nucleotide-binding protein \| Pathway: \| COG: Function unknown CD630_22470 - cspBA Type: Gene Product:Subtilisin-like serine germination relatedprotease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26810 - Type: Gene Product:Putative sporulation protein \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_06000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_17291 - Type: Gene Product:Fragment of putative transcriptional regulator,AraC family (C-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_21710 - Type: Gene Product:Fragment of putative sodium:dicarboxylatesymporter (Part 2) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_25410 - Type: Gene Product:Sodium:glutamate/aspartate symporter family \| Pathway: \| COG: Function unknown CD630_29521 - Type: Gene Product:Fragment of ABC-type transport system,ATP-binding protein (Part 11) \| Pathway: \| COG: Amino acid transport and metabolism, Function unknown, Amino acid transport and metabolism CD630_03150 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_07530 - iscS1 Type: Gene Product:Cysteine desulfurase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14300 - pdaA Type: Gene Product:Exported N-acetylmuramic acid deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05102 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn5397, CTn3-Orf5 (C-terminal region) \| Pathway: \| COG: CD630_07660 - srlEb Type: Gene Product:PTS system, sorbitol-specific IIB C-terminalcomponent (Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01210 - Type: Gene Product:Putative thiosulfate sulfurtransferase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23620 - Type: Gene Product:Fragment of ABC-type transport system, permease(Part 2) \| Pathway: \| COG: Function unknown, Inorganic ion transport and metabolism CD630_22451 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09030 - Type: Gene Product:Fragment of putative oxydoreductase (Part 1) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_35800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20140 - ilvD Type: Gene Product:Dihydroxy-acid dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.58	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_289	10 CD630_10790 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_13770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36220 - Type: Gene Product:Conserved hypothetical protein, PhnA family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06052 - Type: Gene Product: \| Pathway: \| COG: CD630_06080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29730 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_13930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_05860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.02	`NA`	0.58	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_227	24 CD630_03780 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf23 \| Pathway: \| COG: Function unknown CD630_27340 - Type: Gene Product:Putative Na+/H+ antiporter, NhaC family \| Pathway: \| COG: Energy production and conversion CD630_19340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33701 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf2 \| Pathway: \| COG: Function unknown CD630_33861 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf23 \| Pathway: \| COG: Function unknown CD630_32950 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_28430 - Type: Gene Product:Putative zinc-binding dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_32970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32930 - pilMN Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: Function unknown CD630_32910 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19330 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33340 - Type: Gene Product:Putative transcriptional regulator Tn916-like,CTn6-Orf11 \| Pathway: \| COG: Function unknown CD630_33710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf3 \| Pathway: \| COG: Function unknown CD630_27330 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_30240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28440 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_32940 - pilA Type: Gene Product:Type IV pilus protein PilA \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32960 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05140 - cwpV Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_06220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33720 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf4 \| Pathway: \| COG: CD630_33331 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf10 \| Pathway: \| COG: Function unknown CD630_30230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.00006	0.04	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_22	25 CD630_36051 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_18300 - kdpE Type: Gene Product:Two-component response regulator KdpE \| Pathway: \| COG: Signal transduction mechanisms CD630_19760 - mutL Type: Gene Product:DNA mismatch repair protein MutL \| Pathway: \| COG: Replication, recombination and repair CD630_17430 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_17440 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_25950 - pyrR Type: Gene Product:Bifunctional protein PyrR [Includes: Pyrimidineoperon regulatory protein; Uracil phosphoribosyltransferase(UPRTase)] \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25940 - uraA Type: Gene Product:Putative uracil permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_16140 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18290 - kdpD Type: Gene Product:Two-component sensor histidine kinase KdpD \| Pathway: \| COG: Signal transduction mechanisms CD630_27660 - LcpB Type: Gene Product:Surface-anchoring factors, LytR-CpsA-Psr-likeprotein \| Pathway: \| COG: Transcription CD630_24110 - Type: Gene Product:Putative positive regulator of gluconeogenesis;putative phosphotransferase \| Pathway: \| COG: Function unknown CD630_24350 - recO Type: Gene Product:DNA repair protein RecO (Recombination proteinO) \| Pathway: \| COG: Replication, recombination and repair CD630_36060 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_19770 - mutS Type: Gene Product:DNA mismatch repair protein MutS \| Pathway: \| COG: Replication, recombination and repair CD630_19730 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase; putative aluminium resistance \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_19750 - miaA Type: Gene Product:tRNA delta(2)-isopentenylpyrophosphatetransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_36080 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_16130 - cotA Type: Gene Product:Spore outer coat layer protein CotA \| Pathway: \| COG: CD630_17450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16150 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_24100 - ppdK Type: Gene Product:Pyruvate phosphate dikinase (ATP:pyruvate,phosphate phosphotransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24450 - Type: Gene Product:Putative transmembrane signaling protein,TspO/MBR family \| Pathway: \| COG: Signal transduction mechanisms CD630_36070 - Type: Gene Product:Putative iron-sulfur assembly protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24120 - Type: Gene Product:Putative negative regulator of gluconeogenesis \| Pathway: \| COG: Transcription CD630_24340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.000000000004	`NA`	0.58	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26380 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_364	10 CD630_25010 - Type: Gene Product:Putative hydrolase, HAD superfamily, IIBsubfamily \| Pathway: \| COG: Function unknown CD630_22951 - Type: Gene Product:Fragment of putative cell surface protein(C-terminal region) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22190 - Type: Gene Product:Fragment of conjugative transposon protein(central region) \| Pathway: \| COG: Function unknown CD630_06071 - Type: Gene Product:Fragment of transposase-like protein B(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_18090 - Type: Gene Product:Fragment of putative permease, MFS family (Part1) \| Pathway: \| COG: Carbohydrate transport and metabolism, Carbohydrate transport and metabolism CD630_30310 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_19440 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_33911 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_38	22 CD630_11320 - Type: Gene Product:Putative heavy-metal transport/detoxificationprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_t0510 - tRNA-Thr Type: Gene Product: \| Pathway: \| COG: CD630_13140 - truB Type: Gene Product:tRNA pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13160 - rpsO Type: Gene Product:30S ribosomal protein S15 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11300 - Type: Gene Product:Putative lytic transglycosylase-like protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04550 - Type: Gene Product:Putative helicase, UvrD family \| Pathway: \| COG: Replication, recombination and repair CD630_t0490 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_t0720 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0130 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0030 - tRNA-Asn Type: Gene Product: \| Pathway: \| COG: CD630_11290 - coaE Type: Gene Product:Dephospho-CoA kinase (Dephosphocoenzyme Akinase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_t0400 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_13150 - ribC Type: Gene Product:Riboflavin biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_13151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_t0540 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0770 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0670 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0480 - tRNA-Glu Type: Gene Product: \| Pathway: \| COG: CD630_t0280 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_35511 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_11280 - polA Type: Gene Product:DNA polymerase I (POLI) \| Pathway: \| COG: Replication, recombination and repair CD630_t0090 - tRNA-Asp Type: Gene Product: \| Pathway: \| COG:	0	2.29995e-41	0.58	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_119	25 CD630_33170 - fdhF Type: Gene Product:Formate dehydrogenase-H (selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_21230 - Type: Gene Product:Putative multiprotein-complex assembly TPRrepeat-containing protein \| Pathway: \| COG: Function unknown CD630_18220 - bcp Type: Gene Product:Putative thiol peroxidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_12350 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_11910 - fbp Type: Gene Product:Fructose-1,6-bisphosphatase \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_15760 - Type: Gene Product:Putative esterase, SGNH hydrolase-type \| Pathway: \| COG: Amino acid transport and metabolism CD630_28140 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_21240 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown CD630_14130 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_14110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33160 - fdhD Type: Gene Product:Formate dehydrogenase formation protein \| Pathway: \| COG: Energy production and conversion CD630_33140 - hydA Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_18230 - Type: Gene Product:Conserved hypothetical protein, UPF0246 family \| Pathway: \| COG: Replication, recombination and repair CD630_19942 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15770 - pgm Type: Gene Product:Alpha-phosphoglucomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02950 - Type: Gene Product:Putative iron-sulfur-binding protein \| Pathway: \| COG: Energy production and conversion CD630_02960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11900 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_14120 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_18240 - Type: Gene Product:P-type calcium transport ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33150 - hydN2 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_33151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33130 - hydN1 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion	0.00000044	0.000016	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_105	25 CD630_06730 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_19010 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_05220 - Type: Gene Product:Putative c-di-GMP regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_21500 - Type: Gene Product:Putative endonuclease/exonuclease/phosphatase \| Pathway: \| COG: Function unknown CD630_26150 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_23450 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_05130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22320 - asrB Type: Gene Product:Anaerobic sulfite reductase subunit B \| Pathway: \| COG: Energy production and conversion CD630_22300 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02040 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_01632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05230 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Function unknown CD630_26140 - Type: Gene Product:Conserved hypothetical protein, DegV family \| Pathway: \| COG: Function unknown CD630_22310 - asrC Type: Gene Product:Anaerobic sulfite reductase subunit C \| Pathway: \| COG: Energy production and conversion CD630_04560 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_22330 - asrA Type: Gene Product:Anaerobic sulfite reductase subunit A (Anaerobicsulfite reductase iron-sulfur subunit) \| Pathway: \| COG: Energy production and conversion CD630_07070 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_02030 - Type: Gene Product:Putative UvrABC system protein A 1 (UvrA protein1) (Excinuclease ABC subunit A 1) \| Pathway: \| COG: Replication, recombination and repair CD630_30170 - Type: Gene Product:Putative glucose uptake protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21800 - Type: Gene Product:Putative DEAD-like helicase \| Pathway: \| COG: Replication, recombination and repair	0	0.67	0.58	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`