Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 111 - 120 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_289	10 CD630_10790 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_13770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36220 - Type: Gene Product:Conserved hypothetical protein, PhnA family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06052 - Type: Gene Product: \| Pathway: \| COG: CD630_06080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29730 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_13930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_05860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.02	`NA`	0.58	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_209	15 CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_36050 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_13530 - Type: Gene Product:Putative phosphomethylpyrimidine kinase \| Pathway: Cofactor metabolism \| COG: Coenzyme transport and metabolism CD630_36040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_14420 - Type: Gene Product:Putative MORN repeat-containing protein \| Pathway: \| COG: Function unknown CD630_14830 - ssuB Type: Gene Product:ABC-type transport system, sulfonates-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24461 - rpsU Type: Gene Product:30S ribosomal protein S21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14840 - ssuA Type: Gene Product:ABC-type transport system,alkanesulfonates-family extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14810 - Type: Gene Product:Putative tryptophan RNA-binding attenuationprotein \| Pathway: \| COG: Signal transduction mechanisms CD630_14820 - ssuC Type: Gene Product:ABC-type transport system, sulfonates-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36030 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown	0	`NA`	0.63	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_91	21 CD630_13150 - ribC Type: Gene Product:Riboflavin biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_35580 - birA Type: Gene Product:BirA bifunctional protein [Includes: biotinoperon repressor and biotin--[acetyl-CoA-carboxylase]synthetase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_27180 - Type: Gene Product:Putative peptidase C60B, sortase B \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_22710 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_35570 - Type: Gene Product:Putative peptidase \| Pathway: \| COG: Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_35560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_07850 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_35530 - greA Type: Gene Product:Transcription elongation factor greA (Transcriptcleavage factor GreA) \| Pathway: \| COG: Transcription CD630_13140 - truB Type: Gene Product:tRNA pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35550 - coaX Type: Gene Product:Type III pantothenate kinase (Pantothenic acidkinase) (PanK-III) \| Pathway: Cofactor biosynthesis \| COG: Transcription CD630_22720 - Type: Gene Product:Putative protein-tyrosine phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_03410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_07860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_03400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35520 - lysS Type: Gene Product:Lysyl-tRNA synthetase (Lysine--tRNA ligase)(LysRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23980 - Type: Gene Product:Putative 2-thiocytidine tRNA biosynthesis proteinTtcA \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_36190 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_23970 - Type: Gene Product:Putative exonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_35540 - dusB Type: Gene Product:tRNA-dihydrouridine synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13160 - rpsO Type: Gene Product:30S ribosomal protein S15 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.00077	`NA`	0.50	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16440 - Type: Gene Product:Transcriptional regulator, RmlC-type \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_11	22 CD630_11480 - Type: Gene Product:Putative penicillin-binding protein with aN-terminal TonB-box \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11510 - minE Type: Gene Product:Cell division topological specificity factor \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_01720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_13350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_11440 - radC Type: Gene Product:DNA repair protein RadC homolog \| Pathway: \| COG: Replication, recombination and repair CD630_32990 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11530 - mgsA Type: Gene Product:Methylglyoxal synthase (MGS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28270 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_28250 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_28280 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33260 - Type: Gene Product:Integrase, lambdoid phage family Tn916-like,CTn6-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_11500 - minD Type: Gene Product:Septum site-determining protein MinD (Celldivision inhibitor MinD) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11490 - minC Type: Gene Product:Cell division regulator (septum placement) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11470 - Type: Gene Product:Putative permease \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11520 - mrdB Type: Gene Product:Rod shape-determining protein MrdB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11450 - mreB2 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_28260 - Type: Gene Product:Putative aldolase \| Pathway: \| COG: Energy production and conversion CD630_11430 - Type: Gene Product:Putative Maf-like protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_27040 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_33270 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf2 \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_305	18 CD630_04160 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf10 \| Pathway: \| COG: Function unknown CD630_04080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04081 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf2 \| Pathway: \| COG: Function unknown CD630_04170 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf11 \| Pathway: \| COG: Function unknown CD630_04190 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf13 \| Pathway: \| COG: Function unknown CD630_04150 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn2-Orf9 \| Pathway: \| COG: Function unknown CD630_04130 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn2-Orf7 \| Pathway: \| COG: Function unknown CD630_04180 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf12 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04060 - Type: Gene Product:Putative tRNA (Uracil-5-)-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04090 - Type: Gene Product:Putative replication initiation proteinTn1549-like, CTn2-Orf2 \| Pathway: \| COG: Replication, recombination and repair CD630_04140 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf8 \| Pathway: \| COG: Function unknown CD630_04110 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf4 \| Pathway: \| COG: Function unknown CD630_04100 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf3 \| Pathway: \| COG: Replication, recombination and repair CD630_04121 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf6 \| Pathway: \| COG: CD630_04120 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn2-Orf5 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04191 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf14 \| Pathway: \| COG: Function unknown CD630_04200 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn2-Orf15 \| Pathway: \| COG: Function unknown CD630_04210 - Type: Gene Product:DNA topoisomerase protein, type IA, Tn1549-like,CTn2-Orf16 \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.48	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_225	14 CD630_01330 - Type: Gene Product:Putative phosphoribosyl transferase \| Pathway: \| COG: Function unknown CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01320 - Type: Gene Product:Putative DNA helicase, RecD/TraA type \| Pathway: \| COG: Replication, recombination and repair CD630_08650 - Type: Gene Product:Putative ADP-ribose binding protein \| Pathway: \| COG: Function unknown CD630_03690 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf14 \| Pathway: \| COG: Function unknown CD630_03720 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn1-Orf17 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_02120 - Type: Gene Product:Putative sulfatase \| Pathway: \| COG: Function unknown CD630_17010 - recQ Type: Gene Product:ATP-dependent DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_03750 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf20 \| Pathway: \| COG: Function unknown CD630_02400 - Type: Gene Product:Glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34080 - Type: Gene Product:Putative DNA mismatch repair ATPase MutS \| Pathway: \| COG: Replication, recombination and repair CD630_28850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_02110 - licC Type: Gene Product:CTP:phosphocholine cytidylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20150 - Type: Gene Product:Putative VanZ-like transposon protein \| Pathway: \| COG: Defense mechanisms	0.01	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_107	26 CD630_27540 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_33660 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_26600 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_10010 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27530 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_34520 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_09980 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_06540 - Type: Gene Product:ABC-type transport system, permease protein \| Pathway: \| COG: Function unknown CD630_28430 - Type: Gene Product:Putative zinc-binding dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_06520 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_13300 - Type: Gene Product:Putative DNA helicase, UvrD/REP type \| Pathway: \| COG: Function unknown CD630_14250 - Type: Gene Product:Putative magnesium transporter \| Pathway: \| COG: Function unknown CD630_07380 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: Function unknown CD630_16960 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_34480 - Type: Gene Product:Putative ketose-bisphophate aldolase class II;putative tagatose-bisphosphate aldolase GatY \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26610 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32680 - pstS Type: Gene Product:ABC-type transport system, phosphateextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33650 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_34530 - Type: Gene Product:N-acetylglucosamine-6-phosphate deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10000 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_20910 - Type: Gene Product:Putative xanthine/uracil permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_09990 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10060 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Function unknown CD630_34510 - Type: Gene Product:Putative carbohydrate/purine kinase; putativetagatose-6-phosphate kinase LacC \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_06530 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms	0.000000043	`NA`	0.70	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_31440 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_35580 - birA Type: Gene Product:BirA bifunctional protein [Includes: biotinoperon repressor and biotin--[acetyl-CoA-carboxylase]synthetase \| Pathway: \| COG: Coenzyme transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_400	19 CD630_01170 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_21360 - uppS Type: Gene Product:Undecaprenyl pyrophosphate synthetase \| Pathway: \| COG: Lipid transport and metabolism CD630_21361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01160 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_01180 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_01140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24460 - Type: Gene Product:Putative aspartyl/glutamyl-tRNA amidotransferasesubunit B-related \| Pathway: \| COG: Function unknown CD630_21350 - cdsA Type: Gene Product:Phosphatidate cytidylyltransferase CdsA \| Pathway: Phospholipid metabolism \| COG: Lipid transport and metabolism CD630_01120 - ptb Type: Gene Product:phosphate butyryltransferase \| Pathway: \| COG: Energy production and conversion CD630_21370 - frr Type: Gene Product:Ribosome-recycling factor \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01150 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_34740 - atpB Type: Gene Product:ATP synthase subunit a \| Pathway: \| COG: Energy production and conversion CD630_01190 - glmM Type: Gene Product:Phosphoglucosamine mutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34720 - atpF Type: Gene Product:ATP synthase subunit b \| Pathway: \| COG: Energy production and conversion CD630_01130 - buk Type: Gene Product:Butyrate kinase (BK) (Branched-chain carboxylicacid kinase) \| Pathway: \| COG: Energy production and conversion CD630_34760 - atpZ Type: Gene Product:ATP synthase transporter \| Pathway: \| COG: Function unknown CD630_34670 - atpC Type: Gene Product:ATP synthase epsilon chain \| Pathway: \| COG: Energy production and conversion CD630_21400 - rpsB Type: Gene Product:30S ribosomal protein S2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21950 - ftnA Type: Gene Product:Ferritin \| Pathway: \| COG: Inorganic ion transport and metabolism	`NA`	`NA`	0.32	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_27	1 CD630_16630 - guaD Type: Gene Product:Guanine deaminase (Guanase) (Guanine aminase)(Guanine aminohydrolase) (GAH) \| Pathway: \| COG: Nucleotide transport and metabolism	`NA`	`NA`	1.00	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_321	21 CD630_05822 - Type: Gene Product:Fragment of putative signaling protein precursor(N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_09640 - Type: Gene Product:Putative phage baseplate assembly protein \| Pathway: \| COG: Function unknown CD630_28960 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09690 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28990 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09590 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_09700 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09670 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29030 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_09600 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09710 - Type: Gene Product:Putative phage holin protein \| Pathway: \| COG: Function unknown CD630_29070 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_09720 - Type: Gene Product:Putative phage-related cell wall hydrolase(endolysin) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09630 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09730 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29050 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_29010 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29040 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_19981 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_09660 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_09680 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.41	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`