Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 31 - 40 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_205	7 CD630_06750 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_13750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_23011 - Type: Gene Product:Fragment of putative phage protein (C-terminalregion) \| Pathway: \| COG: CD630_12382 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_13830 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_31001 - Type: Gene Product:Fragment of artefact \| Pathway: \| COG: CD630_33721 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf5 \| Pathway: \| COG:	`NA`	`NA`	0.45	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_112	21 CD630_09640 - Type: Gene Product:Putative phage baseplate assembly protein \| Pathway: \| COG: Function unknown CD630_09570 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_09620 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_11550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09590 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_09700 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09630 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09710 - Type: Gene Product:Putative phage holin protein \| Pathway: \| COG: Function unknown CD630_09670 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09610 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09720 - Type: Gene Product:Putative phage-related cell wall hydrolase(endolysin) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11540 - cdPadR1 Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_09730 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09650 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09580 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09680 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09600 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09690 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09660 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	6.7	`NA`	0.42	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_301	16 CD630_15880 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13590 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_15890 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13601 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_15870 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13600 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_35920 - pyrF Type: Gene Product:Orotidine 5'-phosphate decarboxylase (OMPdecarboxylase) (OMPDCase) (OMPdecase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_13610 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_35880 - carB1 Type: Gene Product:Carbamoyl-phosphate synthase large chain 1 \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_15850 - Type: Gene Product:Putative N-acetylglucosamine kinase NAGK-like \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35910 - carA Type: Gene Product:Carbamoyl-phosphate synthase small chain \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35900 - carB2 Type: Gene Product:Carbamoyl-phosphate synthase large chain 2 \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism	0.17	`NA`	0.52	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_22890 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_32	23 CD630_10370 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19740 - hfq Type: Gene Product:Hfq RNA chaperone \| Pathway: \| COG: Signal transduction mechanisms CD630_18650 - Type: Gene Product:Putative DNA recombination protein Tn1549-like,CTn5-Orf24 \| Pathway: \| COG: Function unknown CD630_10400 - addB Type: Gene Product:ATP-dependent nuclease subunit B (ATP-dependenthelicase addB), Superfamily 1 UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_10420 - sbcD Type: Gene Product:Nuclease SbcCD subunit D \| Pathway: \| COG: Replication, recombination and repair CD630_10390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18670 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf26 \| Pathway: \| COG: Function unknown CD630_19720 - Type: Gene Product:Putative peptidase, M20A family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00190 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_14620 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_18680 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf27 \| Pathway: \| COG: Function unknown CD630_23930 - Type: Gene Product:Putative glycosyl transferase, family 51 \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_26730 - appB Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10430 - sbcC Type: Gene Product:Nuclease SbcCD subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_10410 - addA Type: Gene Product:ATP-dependent nuclease subunit A (ATP-dependenthelicase addA) \| Pathway: \| COG: Replication, recombination and repair CD630_10380 - Type: Gene Product:Putative helicase, superfamily 1, UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_18660 - Type: Gene Product:Putative conjugative transposon proteintn1549-like, CTn5-Orf25 \| Pathway: \| COG: Function unknown CD630_18640 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn5-Orf23 \| Pathway: \| COG: Transcription CD630_14610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19420 - trmB Type: Gene Product:tRNA (guanine-N(7)-)-methyltransferase(tRNA(m7G46)-methyltransferase) \| Pathway: tRNA modification \| COG: Energy production and conversion CD630_23940 - polC Type: Gene Product:DNA polymerase III, epsilon subunit \| Pathway: \| COG: Replication, recombination and repair CD630_23920 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_221	19 CD630_12710 - Type: Gene Product:Putative restriction endonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_12690 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_12700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_12680 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_12740 - topA Type: Gene Product:DNA topoisomerase I \| Pathway: \| COG: Replication, recombination and repair CD630_12720 - Type: Gene Product:Putative magnesium chelatase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27580 - Type: Gene Product:Putative N6 adenine-specific DNAmethyltransferase, N12 class \| Pathway: \| COG: Defense mechanisms CD630_12730 - Type: Gene Product:Putative DNA processing Smf single strand bindingprotein \| Pathway: \| COG: Replication, recombination and repair CD630_12760 - Type: Gene Product:Putative replication-associated recombinationprotein A RarA \| Pathway: \| COG: Replication, recombination and repair CD630_12800 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Energy production and conversion CD630_12670 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_12770 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_27570 - Type: Gene Product:Putative acyl transferase/phospholipase \| Pathway: \| COG: Function unknown CD630_12790 - iscS2 Type: Gene Product:Cysteine desulfurase \| Pathway: Cofactor biosynthesis \| COG: Amino acid transport and metabolism CD630_12660 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_27590 - Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_12780 - iscR Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_27560 - ptsH Type: Gene Product:PTS system, HPr protein \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.49	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_351	3 CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription CD630_26330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_20660 - Type: Gene Product:Putative integrase \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_317	14 CD630_00750 - rplW Type: Gene Product:50S ribosomal protein L23 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00880 - rpsE Type: Gene Product:30S ribosomal protein S5 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00810 - rpsQ Type: Gene Product:30S ribosomal protein S17 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00720 - rpsJ Type: Gene Product:30S ribosomal protein S10 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00860 - rplF Type: Gene Product:50S ribosomal protein L6 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01050 - rpsI Type: Gene Product:30S ribosomal protein S9 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00830 - rplX Type: Gene Product:50S ribosomal protein L24 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00990 - rplQ Type: Gene Product:50S ribosomal protein L17 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01040 - rplM Type: Gene Product:50S ribosomal protein L13 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00980 - rpoA Type: Gene Product:DNA-directed RNA polymerase subunit alpha \| Pathway: \| COG: Transcription CD630_22121 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00700 - fusA Type: Gene Product:Elongation factor G (EF-G) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00920 - map1 Type: Gene Product:Methionine aminopeptidase Map1 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00930 - Type: Gene Product:Ribosomal protein L14E/L6E/L27E-like \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.22	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_48	17 CD630_23430 - cat1 Type: Gene Product:Succinyl-CoA:coenzyme A transferase \| Pathway: \| COG: Energy production and conversion CD630_23380 - 4hbD Type: Gene Product:4-hydroxybutyrate dehydrogenase(4-hydroxybutanoate:NAD+ oxidoreductase) \| Pathway: \| COG: Energy production and conversion CD630_23420 - sucD Type: Gene Product:Succinate-semialdehyde dehydrogenase (NAD(P)+) \| Pathway: \| COG: Energy production and conversion CD630_05100 - Type: Gene Product:Putative RNA polymerase sigma factor Tn5397,CTn3-Orf7 \| Pathway: \| COG: Function unknown CD630_05101 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf8 \| Pathway: \| COG: Function unknown CD630_16390 - Type: Gene Product:Putative tellurite associated resistance protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08750 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Function unknown CD630_08730 - Type: Gene Product:ABC-type transport system sugar-familyextracellular solute-binding lipoprotein \| Pathway: \| COG: Function unknown CD630_23390 - cat2 Type: Gene Product:4-hydroxybutyrate CoA transferase \| Pathway: \| COG: Energy production and conversion CD630_08770 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_23440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08760 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Function unknown CD630_08740 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_08780 - Type: Gene Product:ABC-type transport system, sugar-specificpermease \| Pathway: \| COG: Function unknown CD630_23410 - abfD Type: Gene Product:Gamma-aminobutyrate metabolismdehydratase/isomerase [includes: 4- hydroxybutyryl-coadehydratase; vinylacetyl-coa-delta-isomerase] \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16340 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_23400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000068	`NA`	0.33	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_237	20 CD630_34900 - spoIIE Type: Gene Product:Phosphoprotein phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34910 - Type: Gene Product:Putative exopolyphosphatase \| Pathway: \| COG: Nucleotide transport and metabolism, Inorganic ion transport and metabolism CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription CD630_22960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_35010 - mfd Type: Gene Product:Transcription-repair coupling factor (TRCFATP-dependent helicase mfd) \| Pathway: \| COG: Replication, recombination and repair CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_34970 - Type: Gene Product:Bifunctional protein [Includes: Tetrapyrrolemethylase; NTP pyrophosphohydrolase MazG] \| Pathway: \| COG: Function unknown CD630_34930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35000 - prsA Type: Gene Product:Peptidylprolyl isomerase PrsA-like \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35020 - pth Type: Gene Product:Peptidyl-tRNA hydrolase (PTH) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_34960 - hbs Type: Gene Product:DNA-binding protein, non-specific \| Pathway: \| COG: Replication, recombination and repair CD630_34980 - spoVB Type: Gene Product:Stage V sporulation protein B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22970 - Type: Gene Product:Putative phage-related regulatory protein \| Pathway: \| COG: Transcription CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34940 - Type: Gene Product:Putative spore protein \| Pathway: \| COG: Function unknown CD630_34920 - Type: Gene Product:Septum formation initiation protein \| Pathway: \| COG: CD630_34950 - Type: Gene Product:Putative RNA-binding S4 domain-containingprotein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_368	28 CD630_06980 - Type: Gene Product:Putative tRNA/rRNA methyltransferase, SpoU \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_10770 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17330 - hemE Type: Gene Product:Uroporphyrinogen decarboxylase (URO-D) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_00070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00050 - gyrB Type: Gene Product:DNA gyrase subunit B \| Pathway: \| COG: Replication, recombination and repair CD630_10750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00090 - rsbV Type: Gene Product:Anti-anti-sigma factor \| Pathway: \| COG: Signal transduction mechanisms CD630_10730 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_22640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14050 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_15300 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_10780 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00110 - sigB Type: Gene Product:RNA polymerase sigma-B factor \| Pathway: \| COG: Transcription CD630_00040 - recF Type: Gene Product:DNA replication and repair protein RecF \| Pathway: \| COG: Replication, recombination and repair CD630_00020 - dnaN Type: Gene Product:DNA polymerase III subunit beta \| Pathway: \| COG: Replication, recombination and repair CD630_10760 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17320 - Type: Gene Product:Putative cobalamin-binding protein \| Pathway: \| COG: Function unknown CD630_00060 - gyrA Type: Gene Product:DNA gyrase subunit A \| Pathway: \| COG: Replication, recombination and repair CD630_10740 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_06970 - Type: Gene Product:Putative regulator of K+ conductance \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14080 - ddl Type: Gene Product:D-alanine--D-alanine ligase (D-alanylalaninesynthetase) (D-Ala-D-Ala ligase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_14060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23051 - Type: Gene Product:Fragment of transposase (N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_06960 - Type: Gene Product:Putative cation transport protein, Trk family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15310 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22630 - prsA Type: Gene Product:Peptidyl-prolyl cis-trans isomerase, PpiC-type \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	1.3	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`