Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 51 - 60 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_180	9 CD630_14980 - sigA2 Type: Gene Product:RNA polymerase sigma factor SigA2 (sigma-43) \| Pathway: \| COG: Transcription CD630_00511 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29521 - Type: Gene Product:Fragment of ABC-type transport system,ATP-binding protein (Part 11) \| Pathway: \| COG: Amino acid transport and metabolism, Function unknown, Amino acid transport and metabolism CD630_01280 - fabZ Type: Gene Product:(3R)-hydroxymyristoyl-[acyl-carrier-protein]dehydratase \| Pathway: \| COG: Lipid transport and metabolism CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_08080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21800 - Type: Gene Product:Putative DEAD-like helicase \| Pathway: \| COG: Replication, recombination and repair CD630_25620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01270 - mreB1 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	0.03	`NA`	0.36	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_158	13 CD630_19110 - eutW Type: Gene Product:Two-component sensor histidine kinase,Ethanolamine specific \| Pathway: \| COG: Signal transduction mechanisms CD630_19160 - eutK Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19130 - eutB Type: Gene Product:Ethanolamine ammonia lyase large subunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_19120 - eutA Type: Gene Product:Ethanolamine reactivating factor for ammonialyase eutBC \| Pathway: \| COG: Amino acid transport and metabolism CD630_19080 - eutS Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_19090 - eutP Type: Gene Product:Ethanolamine utilization protein, GTPase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_19210 - Type: Gene Product:Putative ethanolamine utilization protein \| Pathway: \| COG: Function unknown CD630_19070 - eutG Type: Gene Product:Ethanolamine iron-dependent Alcoholdehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_19180 - eutM Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19140 - eutC Type: Gene Product:Ethanolamine ammonia lyase small subunit \| Pathway: Amine and polyamine degradation \| COG: Amino acid transport and metabolism CD630_19220 - eutN Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19150 - eutL Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism	1.8	`NA`	0.21	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_78	19 CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_36590 - Type: Gene Product:Putative signal transduction phosphoesterase \| Pathway: \| COG: Signal transduction mechanisms CD630_25280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_36620 - ssb Type: Gene Product:Single-stranded DNA-binding protein(Helix-destabilizing protein) \| Pathway: \| COG: Replication, recombination and repair CD630_36570 - dnaB Type: Gene Product:Replicative DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_36610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36611 - rpsR Type: Gene Product:30S ribosomal protein S18 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03290 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_36630 - rpsF Type: Gene Product:30S ribosomal protein S6 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_36600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36580 - rplI Type: Gene Product:50S ribosomal protein L9 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03280 - pcrA Type: Gene Product:DNA helicase, UvrD/REP type \| Pathway: \| COG: Replication, recombination and repair CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03310 - ppiB Type: Gene Product:Peptidyl-prolyl cis-trans isomerase B (PPIase B)(Rotamase B) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.13	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_276	23 CD630_32020 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_02880 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16890 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_06390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02860 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: CD630_02840 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02900 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31920 - cwp21 Type: Gene Product:Putative cell surface peptidase, M4 family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_33610 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_32030 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_28100 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Replication, recombination and repair CD630_36600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_31700 - eno Type: Gene Product:Enolase (2-phosphoglycerate dehydratase)(2-phospho-D-glycerate hydro-lyase) \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_24190 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_02890 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_02910 - Type: Gene Product:Putative peptidase, M20A family \| Pathway: \| COG: Amino acid transport and metabolism CD630_05750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02850 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02870 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16850 - Type: Gene Product:Putative binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_16870 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG:	0.00000036	`NA`	0.52	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_196	20 CD630_23180 - Type: Gene Product:Putative phosphohexomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08950 - Type: Gene Product:Metallo-beta-lactamase superfamily exportedprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00400 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23190 - rpe Type: Gene Product:Putative ribulose-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23270 - gatA Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23260 - gatB Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00420 - Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23230 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00430 - Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23250 - gatC Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00410 - Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23240 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23210 - tkt Type: Gene Product:Transketolase, central and C-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23200 - rpiB1 Type: Gene Product:Ribose-5-phosphate isomerase B1(Phosphoriboisomerase B) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23220 - tkt Type: Gene Product:Transketolase, N-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.53	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_197	28 CD630_19401 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_05821 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27341 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_29341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_22952 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06941 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22242 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: CD630_12371 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12332 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02921 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09241 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12334 - Type: Gene Product:Fragment of putative phage antirepressor protein(part 2) \| Pathway: \| COG: CD630_26811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_24351 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21152 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05921 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_34531 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17281 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19491 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28181 - Type: Gene Product:Fragment of dihydrofolate reductase familyprotein \| Pathway: \| COG: CD630_05211 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_06230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20060 - Type: Gene Product:Fragment of putative topoisomerase (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_15152 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	1.4	`NA`	0.13	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_15160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_334	6 CD630_06740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09780 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: CD630_18441 - Type: Gene Product:Fragment of putative methyltransferase(N-terminal region) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17591 - Type: Gene Product:Fragment of conserved hypothetical protein,UPF0027 family (C-terminal region) \| Pathway: \| COG: CD630_01960 - Type: Gene Product:Fragment of conserved hypothetical protein,DUF111 family (Part 1) \| Pathway: \| COG: Function unknown, Function unknown	`NA`	`NA`	0.63	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_213	20 CD630_11040 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf19 \| Pathway: \| COG: Function unknown CD630_25730 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIA \| Pathway: \| COG: Function unknown CD630_28560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Replication, recombination and repair CD630_19690 - Type: Gene Product:Putative oligonucleotide binding regulator \| Pathway: \| COG: Function unknown CD630_25720 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_27840 - cwp6 Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase,autolysin \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34050 - Type: Gene Product:Putative iron-onlyhydrogenase,electron-transferring subunit HymA-like \| Pathway: \| COG: Energy production and conversion CD630_19670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08130 - Type: Gene Product:Putative PTS system, IIB component \| Pathway: \| COG: CD630_18950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28570 - Type: Gene Product:Putative hydrolase, HAD superfamily, IAsubfamily \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34060 - Type: Gene Product:Putative iron-onlyhydrogenase,electron-transferring subunit HymB-like \| Pathway: \| COG: Energy production and conversion CD630_33240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08120 - Type: Gene Product:Putative universal stress protein A (UspA) \| Pathway: \| COG: Signal transduction mechanisms CD630_18960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28580 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_19680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19700 - Type: Gene Product:Putative enzyme, cyclase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_35160 - spoVG Type: Gene Product:Regulator required for spore cortex synthesis \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34070 - Type: Gene Product:Putative iron-only hydrogenase, catalytic subunitHymC-like \| Pathway: \| COG: Energy production and conversion	0.00000000059	`NA`	0.41	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_111	23 CD630_03550 - int Type: Gene Product:Integrase Tn916-like, CTn1-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_33700 - Type: Gene Product:Putative recombinase Tn916-like, CTn7-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_15950 - cysE Type: Gene Product:Serine acetyltransferase (SAT) \| Pathway: \| COG: Amino acid transport and metabolism CD630_05190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00190 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26930 - Type: Gene Product:Sodium:dicarboxylate symporter family protein \| Pathway: \| COG: Energy production and conversion CD630_34580 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21280 - ispG Type: Gene Product:4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_16960 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_35950 - Type: Gene Product:Aminopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21300 - dxr Type: Gene Product:1-deoxy-D-xylulose 5-phosphate reductoisomerase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_09930 - Type: Gene Product:Putative thioesterase \| Pathway: \| COG: Function unknown CD630_05081 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf6 \| Pathway: \| COG: Function unknown CD630_15940 - cysK Type: Gene Product:O-acetyl-serine thiol-lyase A(O-acetyl-sulfhydrylase)(OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_36140 - Type: Gene Product:Conserved hypothetical protein, DUF1130 family \| Pathway: \| COG: Function unknown CD630_08610 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02970 - bioB Type: Gene Product:Biotin synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_21290 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05650 - nth Type: Gene Product:Endonuclease III \| Pathway: \| COG: Replication, recombination and repair CD630_08930 - Type: Gene Product:Putative iron-dependent hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_05610 - Type: Gene Product:Putative aldo/keto reductase ; putativeferredoxin \| Pathway: \| COG: Energy production and conversion CD630_08070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000000000027	`NA`	0.54	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_350	22 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08850 - glgP Type: Gene Product:Glycogen phosphorylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10540 - bcd2 Type: Gene Product:Butyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10560 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_16550 - Type: Gene Product:Putative Na+/H+ antiporter NhaC-like \| Pathway: \| COG: Energy production and conversion CD630_10580 - hbd Type: Gene Product:3-hydroxybutyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_17750 - Type: Gene Product:ABC-type transport system, aminoacid-familypermease \| Pathway: \| COG: Amino acid transport and metabolism CD630_25370 - Type: Gene Product:Putative membrane-associated5'-nucleotidase/phosphoesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_08840 - glgA Type: Gene Product:Glycogen synthase (Starch [bacterial glycogen]synthase) \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_08860 - Type: Gene Product:Putative alpha-amylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10550 - etfB Type: Gene Product:Electron transfer flavoproteins subunit beta \| Pathway: \| COG: Energy production and conversion CD630_31450 - cbpA Type: Gene Product:Surface-exposed adhesin \| Pathway: \| COG: Function unknown CD630_10610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28320 - Type: Gene Product:Putative cation efflux protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10570 - crt2 Type: Gene Product:3-hydroxybutyryl-CoA dehydratase (Crotonase) \| Pathway: \| COG: Lipid transport and metabolism CD630_08830 - glgD Type: Gene Product:Glycogen biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10590 - thlA1 Type: Gene Product:Acetoacetyl-CoA thiolase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Lipid transport and metabolism CD630_21900 - Type: Gene Product:Cyclomaltodextrinase (maltogenic alpha-amylase)(cyclomaltodextrin dextrin-hydrolase (decyclizing)) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17740 - Type: Gene Product:ABC-type transport system, aminoacid-familyextracellular solute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_25030 - Type: Gene Product:Putative cation-transporting P-type ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15230 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Function unknown CD630_17760 - Type: Gene Product:ABC-type transport system, aminoacid-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism	0.00000000000026	`NA`	0.61	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_29800 - Type: Gene Product:Putative CRISPR-associated autoregulator DevRfamily protein protein \| Pathway: \| COG: Replication, recombination and repair TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription