Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 91 - 100 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_300	4 CD630_05500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_08600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_05760 - virS Type: Gene Product:Sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_221	19 CD630_12710 - Type: Gene Product:Putative restriction endonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_12690 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_12700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_12680 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_12740 - topA Type: Gene Product:DNA topoisomerase I \| Pathway: \| COG: Replication, recombination and repair CD630_12720 - Type: Gene Product:Putative magnesium chelatase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27580 - Type: Gene Product:Putative N6 adenine-specific DNAmethyltransferase, N12 class \| Pathway: \| COG: Defense mechanisms CD630_12730 - Type: Gene Product:Putative DNA processing Smf single strand bindingprotein \| Pathway: \| COG: Replication, recombination and repair CD630_12760 - Type: Gene Product:Putative replication-associated recombinationprotein A RarA \| Pathway: \| COG: Replication, recombination and repair CD630_12800 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Energy production and conversion CD630_12670 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_12770 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_27570 - Type: Gene Product:Putative acyl transferase/phospholipase \| Pathway: \| COG: Function unknown CD630_12790 - iscS2 Type: Gene Product:Cysteine desulfurase \| Pathway: Cofactor biosynthesis \| COG: Amino acid transport and metabolism CD630_12660 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_27590 - Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_12780 - iscR Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_27560 - ptsH Type: Gene Product:PTS system, HPr protein \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.49	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_127	27 CD630_01920 - cls Type: Gene Product:Cardiolipin synthetase 1 \| Pathway: \| COG: Lipid transport and metabolism CD630_33040 - clpX Type: Gene Product:ATP-dependent Clp protease ATP-binding subunitclpX \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24490 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Function unknown CD630_01900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_01890 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_22260 - sat Type: Gene Product:Streptogramin A acetyltransferase (Virginiamycinacetyltransferase D) (Vat(D)) \| Pathway: \| COG: Function unknown CD630_34680 - atpD Type: Gene Product:ATP synthase subunit beta \| Pathway: \| COG: Energy production and conversion CD630_01950 - Type: Gene Product:Putative NCAIR-mutase (PurE)-related protein \| Pathway: \| COG: Function unknown CD630_34700 - atpA Type: Gene Product:ATPase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_22640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24500 - prmA Type: Gene Product:Ribosomal protein L11 methyltransferase (L11Mtase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33070 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_22520 - Type: Gene Product:Glutamate 2,3-aminomutase \| Pathway: \| COG: Amino acid transport and metabolism CD630_20260 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_24020 - Type: Gene Product:Putative cell wall hydrolase;phosphatase-associated protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24480 - Type: Gene Product:Putative MiaB-like tRNA modifying enzyme \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33050 - clpP1 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 1 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01910 - Type: Gene Product:Putative DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_34690 - atpG Type: Gene Product:ATP synthase gamma chain \| Pathway: \| COG: Energy production and conversion CD630_07550 - pilJ Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_34710 - atpH Type: Gene Product:ATP synthase subunit delta \| Pathway: \| COG: Energy production and conversion CD630_34750 - atpI Type: Gene Product:ATP synthase subunit I \| Pathway: \| COG: Function unknown CD630_33080 - rph Type: Gene Product:Bifunctional enzyme, tRNA nucleotidyltransferase; Nucleoside-triphosphatase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24470 - Type: Gene Product:Putative histidine triad (HIT) protein \| Pathway: \| COG: Nucleotide transport and metabolism, Carbohydrate transport and metabolism CD630_22630 - prsA Type: Gene Product:Peptidyl-prolyl cis-trans isomerase, PpiC-type \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33060 - tig Type: Gene Product:Trigger factor (TF) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.43	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_47	20 CD630_23130 - Type: Gene Product:ABC-type transport system, molybdenum-likeATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08610 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25450 - bcsA Type: Gene Product:Cellulose synthase catalytic subunit(UDP-forming) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08620 - Type: Gene Product:PTS system, lactose/cellobiose-family IICmembrane component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25460 - Type: Gene Product:Endoglucanase (cellulase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23120 - Type: Gene Product:ABC-type transport system, molybdenum-likepermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08640 - Type: Gene Product:Maltose-6'-phosphate glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20180 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_25420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23110 - Type: Gene Product:ABC-type transport system, molybdenum-likeextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08630 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25430 - Type: Gene Product:Putative membrane-bound 0-ACYL transferase, MBOATfamily \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.05	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20180 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_317	14 CD630_00750 - rplW Type: Gene Product:50S ribosomal protein L23 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00880 - rpsE Type: Gene Product:30S ribosomal protein S5 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00810 - rpsQ Type: Gene Product:30S ribosomal protein S17 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00720 - rpsJ Type: Gene Product:30S ribosomal protein S10 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00860 - rplF Type: Gene Product:50S ribosomal protein L6 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01050 - rpsI Type: Gene Product:30S ribosomal protein S9 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00830 - rplX Type: Gene Product:50S ribosomal protein L24 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00990 - rplQ Type: Gene Product:50S ribosomal protein L17 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01040 - rplM Type: Gene Product:50S ribosomal protein L13 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00980 - rpoA Type: Gene Product:DNA-directed RNA polymerase subunit alpha \| Pathway: \| COG: Transcription CD630_22121 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00700 - fusA Type: Gene Product:Elongation factor G (EF-G) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00920 - map1 Type: Gene Product:Methionine aminopeptidase Map1 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00930 - Type: Gene Product:Ribosomal protein L14E/L6E/L27E-like \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.22	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_237	20 CD630_34900 - spoIIE Type: Gene Product:Phosphoprotein phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34910 - Type: Gene Product:Putative exopolyphosphatase \| Pathway: \| COG: Nucleotide transport and metabolism, Inorganic ion transport and metabolism CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription CD630_22960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_35010 - mfd Type: Gene Product:Transcription-repair coupling factor (TRCFATP-dependent helicase mfd) \| Pathway: \| COG: Replication, recombination and repair CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_34970 - Type: Gene Product:Bifunctional protein [Includes: Tetrapyrrolemethylase; NTP pyrophosphohydrolase MazG] \| Pathway: \| COG: Function unknown CD630_34930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35000 - prsA Type: Gene Product:Peptidylprolyl isomerase PrsA-like \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35020 - pth Type: Gene Product:Peptidyl-tRNA hydrolase (PTH) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_34960 - hbs Type: Gene Product:DNA-binding protein, non-specific \| Pathway: \| COG: Replication, recombination and repair CD630_34980 - spoVB Type: Gene Product:Stage V sporulation protein B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22970 - Type: Gene Product:Putative phage-related regulatory protein \| Pathway: \| COG: Transcription CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34940 - Type: Gene Product:Putative spore protein \| Pathway: \| COG: Function unknown CD630_34920 - Type: Gene Product:Septum formation initiation protein \| Pathway: \| COG: CD630_34950 - Type: Gene Product:Putative RNA-binding S4 domain-containingprotein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_143	22 CD630_36050 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_31480 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: Function unknown CD630_14510 - folB Type: Gene Product:Dihydroneopterin aldolase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14430 - Type: Gene Product:Putative Ca++-chelating serine protease, SCP-likeextracellular domain protein \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14470 - pabC Type: Gene Product:Aminodeoxychorismate lyase(4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14530 - aroF Type: Gene Product:Phospho-2-dehydro-3-deoxyheptonate aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14450 - pabA Type: Gene Product:Para-aminobenzoate/anthranilate synthaseglutamine amidotransferase component II [Includes:Para-aminobenzoate synthase glutamine amidotransferasecomponent II; Anthranilate synthase component II] \| Pathway: \| COG: Amino acid transport and metabolism CD630_34370 - cobS Type: Gene Product:Cobalamin synthase CobS (Cobalamin-5-phosphatesynthase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14490 - folE Type: Gene Product:GTP cyclohydrolase 1 (GTP cyclohydrolase I)(GTP-CH-I) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_36040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_31490 - Type: Gene Product:DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_34390 - cobT Type: Gene Product:Nicotinate-nucleotide--dimethylbenzimidazolephosphoribosyltransferase (NN:DBI PRT)(N(1)-alpha-phosphoribosyltransferase) \| Pathway: Nucleoside biosynthesis \| COG: Coenzyme transport and metabolism CD630_01500 - Type: Gene Product:Putative peptidase, M22 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_14500 - folP Type: Gene Product:Dihydropteroate synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14520 - folK Type: Gene Product:2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_14440 - Type: Gene Product:Putative exported polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14460 - pabB Type: Gene Product:Para-aminobenzoate synthase component I \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_34360 - cobC Type: Gene Product:Cobalamin biosynthesis phosphoglycerate mutaseCobC \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01980 - guaA Type: Gene Product:Glutamine amidotransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_36030 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_14480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04020 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_63	17 CD630_09000 - opuCA Type: Gene Product:ABC-type transport system, glycinebetaine/carnitine/choline ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_20920 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_34780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_09010 - opuCC Type: Gene Product:ABC-type transport system, glycinebetaine/carnitine/choline permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_21580 - gabT Type: Gene Product:4-aminobutyrate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_31700 - eno Type: Gene Product:Enolase (2-phosphoglycerate dehydratase)(2-phospho-D-glycerate hydro-lyase) \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_17110 - Type: Gene Product:Conserved hypothetical protein, UPF0145 family \| Pathway: \| COG: Function unknown CD630_29640 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_20460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23870 - Type: Gene Product:Alpha-hydroxy acid dehydrogenase, FMN-dependent \| Pathway: \| COG: Energy production and conversion CD630_20910 - Type: Gene Product:Putative xanthine/uracil permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_27670 - cwp19 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20980 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08790 - Type: Gene Product:Putative carbohydrate kinase \| Pathway: \| COG: Carbohydrate transport and metabolism	0.0000054	`NA`	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_05090 - Type: Gene Product:Transcriptional regulator, HTH-type Tn5397,CTn3-Orf9 \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_253	9 CD630_17292 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04981 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf20.1 \| Pathway: \| COG: Function unknown CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34392 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05490 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11230 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_19910 - Type: Gene Product:Fragment of integrase (C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_14260 - Type: Gene Product:Fragment of isochorismatase (Part 2) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism	0.59	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_12870 - fur Type: Gene Product:Transcriptional regulator, Fur family \| Pathway: \| COG: Inorganic ion transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_159	24 CD630_04000 - etfB1 Type: Gene Product:Beta-subunit of electron transfer flavoprotein \| Pathway: \| COG: Energy production and conversion CD630_07280 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit alpha/beta \| Pathway: \| COG: Energy production and conversion CD630_03940 - ldhA Type: Gene Product:D-lactate dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_07180 - fhs Type: Gene Product:Formate--tetrahydrofolate ligase(Formyltetrahydrofolate synthetase) (FHS) (FTHFS) \| Pathway: One-carbon metabolism \| COG: Nucleotide transport and metabolism CD630_03960 - hadI Type: Gene Product:Activator of 2-hydroxyisocaproyl-CoA dehydratase \| Pathway: \| COG: Lipid transport and metabolism CD630_07200 - folD Type: Gene Product:Bifunctional protein folD [Includes:Methylenetetrahydrofolate dehydrogenase ;Methenyltetrahydrofolate cyclohydrolase] \| Pathway: One-carbon metabolism \| COG: Coenzyme transport and metabolism CD630_03980 - hadC Type: Gene Product:Subunit of oxygen-sensitive2-hydroxyisocaproyl-CoA dehydratase C \| Pathway: \| COG: Amino acid transport and metabolism CD630_23490 - grdC Type: Gene Product:Glycine reductase complex component C subunitbeta (Protein PC beta) \| Pathway: \| COG: Energy production and conversion CD630_20200 - clpB Type: Gene Product:Chaperone protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_07220 - metF Type: Gene Product:5,10-methylenetetrahydrofolate reductase \| Pathway: One-carbon metabolism \| COG: Amino acid transport and metabolism CD630_07260 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_07240 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase,nickel-inserting subunit \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_04010 - etfA1 Type: Gene Product:Alpha-subunit of electron transfer flavoprotein \| Pathway: \| COG: Energy production and conversion CD630_07290 - gcvH Type: Gene Product:Glycine cleavage system H protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_03950 - hadA Type: Gene Product:Isocaprenoyl-CoA:2-hydroxyisocaproateCoA-transferase \| Pathway: \| COG: Energy production and conversion CD630_03970 - hadB Type: Gene Product:Subunit of oxygen-sensitive2-hydroxyisocaproyl-CoA dehydratase B \| Pathway: \| COG: Amino acid transport and metabolism CD630_07190 - fchA Type: Gene Product:Methenyltetrahydrofolate cyclohydrolase(5,10-methenyltetrahydrofolate 5-hydrolase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_03990 - acdB Type: Gene Product:Acyl-CoA dehydrogenase, short-chain specific \| Pathway: \| COG: Lipid transport and metabolism CD630_07210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07250 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit delta \| Pathway: \| COG: Energy production and conversion CD630_07230 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, dihydrolipoyldehydrogenase subunit \| Pathway: \| COG: Energy production and conversion CD630_07270 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, methyltransferasesubunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_23480 - grdD Type: Gene Product:Glycine reductase complex component C subunitalpha (Protein PC alpha) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.46	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription