Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 101 - 110 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_19	31 CD630_33170 - fdhF Type: Gene Product:Formate dehydrogenase-H (selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_24160 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_00380 - acoC Type: Gene Product:Acetoin dehydrogenase E2 component(dihydrolipoamide acetyltransferase) \| Pathway: \| COG: Energy production and conversion CD630_28210 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_07830 - spoIVB Type: Gene Product:Stage IV sporulation protein SpoIVB, S55peptidase family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27080 - aroE2 Type: Gene Product:Shikimate dehydrogenase 2 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_00360 - acoA Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentalpha subunit) \| Pathway: \| COG: Energy production and conversion CD630_24140 - Type: Gene Product:PTS system, Sorbitol-like IIA component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27070 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07990 - Type: Gene Product:Putative beta-alanine CoA-transferase, familyIII \| Pathway: \| COG: Energy production and conversion CD630_16450 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22800 - Type: Gene Product:PTS system, fructose/mannitol family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00390 - acoL Type: Gene Product:Acetoin dehydrogenase E3 component(dihydrolipoamide dehydrogenase) \| Pathway: \| COG: Energy production and conversion CD630_22820 - Type: Gene Product:PTS system, fructose/mannitol family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27090 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_33160 - fdhD Type: Gene Product:Formate dehydrogenase formation protein \| Pathway: \| COG: Energy production and conversion CD630_33140 - hydA Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_00350 - Type: Gene Product:Transcriptional regulator \| Pathway: \| COG: Transcription CD630_07840 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00370 - acoB Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentbeta subunit) \| Pathway: \| COG: Energy production and conversion CD630_28200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24150 - Type: Gene Product:Putative sorbitol-like operon activator protein(Glucitol) \| Pathway: \| COG: CD630_07980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16460 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_24130 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_27100 - Type: Gene Product:Putative sugar phosphate epimerase/isomerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28220 - Type: Gene Product:Putative glutamate carboxypeptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_33150 - hydN2 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_33151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33130 - hydN1 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_22830 - Type: Gene Product:Sigma-54-dependent regulator, PTS regulatorydomain \| Pathway: \| COG: Transcription	0.31	`NA`	0.53	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_05790 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_22830 - Type: Gene Product:Sigma-54-dependent regulator, PTS regulatorydomain \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_190	13 CD630_04280 - Type: Gene Product:Transcriptional regulator, AraC familyTn1549-like, CTn2-Orf23 \| Pathway: \| COG: Transcription CD630_04300 - Type: Gene Product:ABC-type transport system, cobalt-specificpermease Tn1549-like, CTn2-Orf25 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04290 - Type: Gene Product:Putative membrane protein Tn1549-like,CTn2-Orf24 \| Pathway: \| COG: Function unknown CD630_04310 - Type: Gene Product:ABC-type transport system, cobalt-specificATP-binding protein Tn1549-like, CTn2-Orf26 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15910 - kdpA Type: Gene Product:Potassium-translocating ATPase A chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04330 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_15930 - kdpC Type: Gene Product:Potassium-transporting ATPase C chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04260 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf21 \| Pathway: \| COG: Function unknown CD630_15920 - kdpB Type: Gene Product:Potassium-transporting ATPase B chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04340 - Type: Gene Product:Putative drug/sodium antiporter, MATE family,Tn1549-like, CTn2-Orf29 \| Pathway: \| COG: Defense mechanisms CD630_04250 - Type: Gene Product:Putative endonuclease relaxase Tn1549-like,CTn2-Orf20 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04270 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn2-Orf22 \| Pathway: \| COG: Transcription CD630_04320 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf27 \| Pathway: \| COG: Defense mechanisms	`NA`	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_191	28 CD630_01620 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Function unknown CD630_13000 - pepA Type: Gene Product:Leucine aminopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04410 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_01600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_28310 - Type: Gene Product:Collagen binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28350 - abgT Type: Gene Product:Aminobenzoyl-glutamate transport protein \| Pathway: \| COG: Coenzyme transport and metabolism CD630_02410 - Type: Gene Product:Phosphate-threonine kinase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32830 - pflE Type: Gene Product:Pyruvate formate-lyase (activating enzyme) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_12980 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02020 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24310 - Type: Gene Product:Putative nitrite/sulphite reductase \| Pathway: \| COG: Energy production and conversion CD630_01632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02750 - splB Type: Gene Product:Spore photoproduct (thymine dimer) lyase, radicalS-adenosylmethionine superfamily \| Pathway: \| COG: Replication, recombination and repair CD630_01610 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_01290 - Type: Gene Product:Conserved hypothetical protein, DUF1256 family \| Pathway: \| COG: Function unknown CD630_02420 - Type: Gene Product:Phosphothreonine N-acetylglucosamine catalysis \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28340 - glyA Type: Gene Product:Serine hydroxymethyltransferase (Serinemethylase) (SHMT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_28360 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32820 - pflD Type: Gene Product:Pyruvate formate-lyase \| Pathway: \| COG: Energy production and conversion CD630_12990 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_32140 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_12970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.0000000000000077	`NA`	0.58	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_192	23 CD630_27610 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_36550 - purA Type: Gene Product:Adenylosuccinate synthetase (IMP--aspartateligase) (AdSS) (AMPSase) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_17330 - hemE Type: Gene Product:Uroporphyrinogen decarboxylase (URO-D) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_13100 - rbfA Type: Gene Product:Ribosome-binding factor A \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13080 - Type: Gene Product:Ribosomal protein L7Ae/L30e/S12e/Gadd45 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22750 - topB2 Type: Gene Product:DNA topoisomerase III \| Pathway: \| COG: Replication, recombination and repair CD630_07100 - Type: Gene Product:Conserved hypothetical protein, DUF523 family \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_28020 - tgt Type: Gene Product:Queuine tRNA-ribosyltransferase (tRNA-guaninetransglycosylase) (Guanine insertion enzyme) \| Pathway: tRNA modification \| COG: Translation, ribosomal structure and biogenesis CD630_28000 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_28040 - queA Type: Gene Product:S-adenosylmethionine:tRNAribosyltransferase-isomerase (Queuosine biosynthesisprotein QueA) \| Pathway: tRNA modification \| COG: Translation, ribosomal structure and biogenesis CD630_17320 - Type: Gene Product:Putative cobalamin-binding protein \| Pathway: \| COG: Function unknown CD630_13071 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_13070 - nusA Type: Gene Product:Transcription elongation protein \| Pathway: \| COG: Transcription CD630_36560 - Type: Gene Product:Conserved hypothetical protein with a TonB box \| Pathway: \| COG: CD630_17340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_13090 - infB Type: Gene Product:Translation initiation factor IF-2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_07090 - mutS2 Type: Gene Product:DNA mismatch repair protein \| Pathway: \| COG: Replication, recombination and repair CD630_26820 - pfo Type: Gene Product:Pyruvate-ferredoxin oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_28030 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_13050 - dnaF Type: Gene Product:DNA polymerase III PolC-type (PolIII) \| Pathway: \| COG: Replication, recombination and repair	0.00069	`NA`	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_193	21 CD630_06512 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_36361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06030 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: CD630_03540 - Type: Gene Product:Fragment of putative membrane protein (Part 1) \| Pathway: \| COG: CD630_20141 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32561 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32471 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_34391 - Type: Gene Product:Putative spore-associated protein \| Pathway: \| COG: CD630_25622 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29071 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_23591 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03901 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29160 - Type: Gene Product:Putative phage major capsid protein \| Pathway: \| COG: Function unknown CD630_29170 - Type: Gene Product:Putative scaffold protein \| Pathway: \| COG: Function unknown CD630_29090 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31501 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.25	Inferelator: 4 Hypergeometric: 2 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_23160 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_194	20 CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_09960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_07590 - plfB Type: Gene Product:Formate acetyltransferase (Pyruvateformate-lyase) \| Pathway: \| COG: Energy production and conversion CD630_07580 - pflA Type: Gene Product:Pyruvate formate-lyase activating enzyme \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_36650 - Type: Gene Product:Conserved hypothetical protein, DUF951 family \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09940 - Type: Gene Product:Putative serine-pyruvate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_36640 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_09950 - serA Type: Gene Product:Putative D-3-phosphoglycerate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism	0.0000076	2.8	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_195	15 CD630_07560 - Type: Gene Product:Nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_31461 - Type: Gene Product:Fragment of putative transposase, IS4 family(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_13400 - Type: Gene Product:Putative galactose-1-phosphateuridylyltransferase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15380 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_07550 - pilJ Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_18310 - Type: Gene Product:Putative cation (Mg2+ and Co2+)transport-related, membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23020 - tlpB Type: Gene Product:Fragment of transposase-like protein B(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_05630 - Type: Gene Product:Putative iron-sulfur cluster-binding protein \| Pathway: \| COG: Energy production and conversion CD630_13580 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05640 - Type: Gene Product:putative ATP-dependent protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18410 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_18420 - Type: Gene Product:Conserved hypothetical protein, DUF218 family \| Pathway: \| COG: Function unknown CD630_18400 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_05620 - Type: Gene Product:Putative RusA-like endodeoxyribonuclease \| Pathway: \| COG: Function unknown CD630_13570 - Type: Gene Product:Putative peptidyl-prolyl isomerase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	`NA`	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_196	20 CD630_23180 - Type: Gene Product:Putative phosphohexomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08950 - Type: Gene Product:Metallo-beta-lactamase superfamily exportedprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00400 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23190 - rpe Type: Gene Product:Putative ribulose-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23270 - gatA Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23260 - gatB Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00420 - Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23230 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00430 - Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23250 - gatC Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00410 - Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23240 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23210 - tkt Type: Gene Product:Transketolase, central and C-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23200 - rpiB1 Type: Gene Product:Ribose-5-phosphate isomerase B1(Phosphoriboisomerase B) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23220 - tkt Type: Gene Product:Transketolase, N-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.53	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_197	28 CD630_19401 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_05821 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27341 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_29341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_22952 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06941 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22242 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: CD630_12371 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12332 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02921 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09241 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12334 - Type: Gene Product:Fragment of putative phage antirepressor protein(part 2) \| Pathway: \| COG: CD630_26811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_24351 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21152 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05921 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_34531 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17281 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19491 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28181 - Type: Gene Product:Fragment of dihydrofolate reductase familyprotein \| Pathway: \| COG: CD630_05211 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_06230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20060 - Type: Gene Product:Fragment of putative topoisomerase (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_15152 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	1.4	`NA`	0.13	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_15160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_198	21 CD630_16940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01230 - murA Type: Gene Product:UDP-N-acetylglucosamine1-carboxyvinyltransferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_05091 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf10 \| Pathway: \| COG: CD630_22270 - Type: Gene Product:Putative radical SAM superfamily lipoprotein \| Pathway: \| COG: Energy production and conversion CD630_33000 - engB Type: Gene Product:GTP-binding protein EngB; putative endoglucanase \| Pathway: \| COG: Function unknown CD630_05090 - Type: Gene Product:Transcriptional regulator, HTH-type Tn5397,CTn3-Orf9 \| Pathway: \| COG: Transcription CD630_33010 - lon Type: Gene Product:ATP-dependent protease La, S16 peptidase family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01220 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: Function unknown CD630_26890 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_26910 - hpt Type: Gene Product:Hypoxanthine phosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_33940 - pyk Type: Gene Product:Pyruvate kinase (PK) \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_33030 - chrA Type: Gene Product:Chromate transport protein ChrA \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26900 - Type: Gene Product:Putative membrane-associated phosphatase \| Pathway: \| COG: Lipid transport and metabolism CD630_22280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26920 - Type: Gene Product:Putative threonine-phosphate decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_26880 - sspA Type: Gene Product:Small, acid-soluble spore protein alpha \| Pathway: \| COG: Function unknown CD630_01280 - fabZ Type: Gene Product:(3R)-hydroxymyristoyl-[acyl-carrier-protein]dehydratase \| Pathway: \| COG: Lipid transport and metabolism CD630_33950 - pfkA Type: Gene Product:6-phosphofructokinase (Phosphofructokinase)(Phosphohexokinase) \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_33020 - chrA Type: Gene Product:Chromate transport protein ChrA \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16950 - Type: Gene Product:Putative symporter protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01270 - mreB1 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	0.000083	0	0.46	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`