Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 81 - 90 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_35	9 CD630_31460 - Type: Gene Product:Fragment of putative sortase B (Part 1) \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_19904 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_23910 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09401 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09780 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: CD630_19820 - Type: Gene Product:Fragment of putative phenazine biosynthesisprotein (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_12360 - Type: Gene Product:Fragment of putative phage protein (part 1) \| Pathway: \| COG: CD630_05780 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22180 - int Type: Gene Product:Fragment of putative integrase (C-terminalregion) \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.43	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_05790 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_219	20 CD630_28620 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_35320 - phnM Type: Gene Product:Putative carbon-phosphorus lyase complex subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35310 - Type: Gene Product:Putative polymerase/histidinol phosphatase-like \| Pathway: \| COG: Function unknown CD630_35340 - phnK Type: Gene Product:ABC-type transport system, phosphonate-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04350 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn2-Orf31 \| Pathway: \| COG: Function unknown CD630_35350 - phnJ Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01650 - Type: Gene Product:Putative amino acid transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35300 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_35280 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01660 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_28600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18780 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn5-Orf38 \| Pathway: \| COG: Function unknown CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35360 - phnI Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35370 - phnH Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35380 - phnG Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28590 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.35	`NA`	0.43	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_315	32 CD630_28450 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_14920 - Type: Gene Product:Histidine kinase, negative regulator ofsporulation \| Pathway: \| COG: Signal transduction mechanisms CD630_04430 - ortA Type: Gene Product:2-amino-4-ketopentanoate thiolase alpha subunit \| Pathway: \| COG: Function unknown CD630_04470 - Type: Gene Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase \| Pathway: \| COG: Function unknown CD630_06710 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_04450 - oraS Type: Gene Product:D-ornithine aminomutase S component \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_35420 - spmA Type: Gene Product:Spore maturation protein A \| Pathway: \| COG: Function unknown CD630_35810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08640 - Type: Gene Product:Maltose-6'-phosphate glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04480 - orr Type: Gene Product:ornithine racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_17610 - Type: Gene Product:Putative phenazine biosynthesis PhzC/PhzFprotein \| Pathway: \| COG: Function unknown CD630_13010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04420 - ord Type: Gene Product:2,4-diaminopentanoate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04460 - oraE Type: Gene Product:D-ornithine aminomutase E component \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_35820 - Type: Gene Product:Putative pseudouridine synthase RsuA-like \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04440 - ortB Type: Gene Product:2-amino-4-ketopentanoate thiolase beta subunit \| Pathway: \| COG: Function unknown CD630_08630 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04490 - Type: Gene Product:Na+/H+ antiporter, NhaA family \| Pathway: \| COG: Energy production and conversion CD630_23330 - mtlR Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_35410 - spmB Type: Gene Product:Spore maturation protein B \| Pathway: \| COG: Function unknown CD630_35800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35830 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17600 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_14020 - glpQ Type: Gene Product:Glycerophosphoryl diester phosphodiesterase \| Pathway: \| COG: Energy production and conversion	0.00000000000083	`NA`	0.43	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_86	24 CD630_14940 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_27830 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21660 - msrAB Type: Gene Product:Peptide methionine sulfoxide reductase MsrA/MsrB \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08180 - Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14190 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_28920 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28900 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_14210 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_09770 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05440 - Type: Gene Product:Putative ornithine cyclodeaminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14950 - proC Type: Gene Product:Pyrroline-5-carboxylate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_27780 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18080 - Type: Gene Product:Pyridoxal-dependent decarboxylase, group IVdecarboxylase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_21670 - Type: Gene Product:Acyl transferase/acylhydrolase/lysophospholipase \| Pathway: \| COG: Function unknown CD630_27820 - cwp7 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08190 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_28910 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_14200 - dccA Type: Gene Product:Diguanylate cyclase protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26680 - Type: Gene Product:Transcription antiterminator, licT family \| Pathway: \| COG: Transcription CD630_09750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09760 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18070 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_16440 - Type: Gene Product:Transcriptional regulator, RmlC-type \| Pathway: \| COG: Transcription CD630_32040 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	0.00000033	0	0.43	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_6	27 CD630_07690 - Type: Gene Product:Putative oxidoreductase subunit \| Pathway: \| COG: Energy production and conversion CD630_18650 - Type: Gene Product:Putative DNA recombination protein Tn1549-like,CTn5-Orf24 \| Pathway: \| COG: Function unknown CD630_09820 - ubiA Type: Gene Product:Putative UbiA prenyltransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_18670 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf26 \| Pathway: \| COG: Function unknown CD630_09840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_13440 - Type: Gene Product:Putative cell wall biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13460 - Type: Gene Product:Conserved hypothetical protein, DUF1700 \| Pathway: \| COG: Function unknown CD630_34880 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13500 - cprB Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_13520 - cprK Type: Gene Product:Two-component sensor histidine kinase, cationicantimicrobial peptide resistance \| Pathway: \| COG: Signal transduction mechanisms CD630_27110 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_18680 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf27 \| Pathway: \| COG: Function unknown CD630_13480 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_09810 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_18500 - Type: Gene Product:Transcriptional regulator, AraC family;Tn1549-like, CTn5-Orf6 \| Pathway: \| COG: Transcription CD630_15960 - map2 Type: Gene Product:Methionine aminopeptidase Map2 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09830 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIB \| Pathway: \| COG: Amino acid transport and metabolism CD630_13490 - cprA Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_13450 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_04880 - Type: Gene Product:Putative small multidrug resistance SugE-likeprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18660 - Type: Gene Product:Putative conjugative transposon proteintn1549-like, CTn5-Orf25 \| Pathway: \| COG: Function unknown CD630_18640 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn5-Orf23 \| Pathway: \| COG: Transcription CD630_13470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13510 - cprC Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_34890 - Type: Gene Product:Putative oligoendopeptidase F, peptidase M3Bfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_14380 - Type: Gene Product:Putative TPR repeat-containing protein \| Pathway: \| COG: Function unknown CD630_23920 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown	0	0.00039	0.43	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_404	13 CD630_04990 - Type: Gene Product:Putative replication initiation factor Tn5397,CTn3-Orf20 \| Pathway: \| COG: Transcription CD630_04991 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf19 \| Pathway: \| COG: Function unknown CD630_05010 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf17 \| Pathway: \| COG: Function unknown CD630_04980 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn5397, CTn3-Orf21 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_33860 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf22 \| Pathway: \| COG: Function unknown CD630_05030 - Type: Gene Product:Putative membrane protein Tn5397, CTn3-Orf15 \| Pathway: \| COG: Function unknown CD630_04960 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf23 \| Pathway: \| COG: Function unknown CD630_05020 - Type: Gene Product:Putative ATPase Tn5397, CTn3-Orf16 \| Pathway: \| COG: Function unknown CD630_05000 - Type: Gene Product:Putative antirestriction protein Tn5397,CTn3-Orf18 \| Pathway: \| COG: Function unknown CD630_04970 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf22 \| Pathway: \| COG: Function unknown CD630_33850 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf21 \| Pathway: \| COG: Function unknown CD630_10940 - Type: Gene Product:Putative RNA polymerase sigma factor Tn1549-like,CTn4-Orf31 \| Pathway: \| COG: Function unknown CD630_33910 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn7-Orf30 \| Pathway: \| COG: Function unknown	0.12	0.51	0.43	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_194	20 CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_09960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_07590 - plfB Type: Gene Product:Formate acetyltransferase (Pyruvateformate-lyase) \| Pathway: \| COG: Energy production and conversion CD630_07580 - pflA Type: Gene Product:Pyruvate formate-lyase activating enzyme \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_36650 - Type: Gene Product:Conserved hypothetical protein, DUF951 family \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09940 - Type: Gene Product:Putative serine-pyruvate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_36640 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_09950 - serA Type: Gene Product:Putative D-3-phosphoglycerate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism	0.0000076	2.8	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_43	25 CD630_15880 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13781 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_17720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20101 - ermC Type: Gene Product:23S rRNA methylase leader peptide \| Pathway: \| COG: CD630_15860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13782 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_20751 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12310 - Type: Gene Product:Putative site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_01800 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_13011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15890 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15870 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04371 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29661 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15850 - Type: Gene Product:Putative N-acetylglucosamine kinase NAGK-like \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription	0.0000000000018	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_126	7 CD630_31850 - Type: Gene Product:Fragment of putative RNA-binding protein (Part2) \| Pathway: \| COG: Function unknown, Function unknown CD630_12840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_02731 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06470 - Type: Gene Product:Fragment of putative fic family protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_18110 - Type: Gene Product:Fragment of putative two-component sensorhistidine kinase (N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_28240 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_12830 - Type: Gene Product:Conserved hypothetical protein, UPF0297 family \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30620 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_279	26 CD630_13960 - Type: Gene Product:Putative amino acid amidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_30780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27010 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_30430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02160 - Type: Gene Product:Transposase IS200/IS605-like OrfB \| Pathway: \| COG: Replication, recombination and repair CD630_17300 - Type: Gene Product:Putative ATP-binding protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_24020 - Type: Gene Product:Putative cell wall hydrolase;phosphatase-associated protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_02120 - Type: Gene Product:Putative sulfatase \| Pathway: \| COG: Function unknown CD630_24040 - Type: Gene Product:DNA topoisomerase type IA \| Pathway: \| COG: Replication, recombination and repair CD630_31230 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_13950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_14970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05310 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_11560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03050 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00100 - rsbW Type: Gene Product:Serine-protein kinase RsbW \| Pathway: \| COG: Signal transduction mechanisms CD630_02110 - licC Type: Gene Product:CTP:phosphocholine cytidylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32590 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_08090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription CD630_09231 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_19320 - Type: Gene Product:Putative phage integrase \| Pathway: \| COG: Replication, recombination and repair CD630_02150 - Type: Gene Product:Transposase IS200/IS605-like OrfA \| Pathway: \| COG: Replication, recombination and repair CD630_31220 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_29260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000000029	0.35	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`