| COG0022 | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit |
| COG0039 | Malate/lactate dehydrogenases |
| COG0045 | Succinyl-CoA synthetase, beta subunit |
| COG0055 | F0F1-type ATP synthase, beta subunit |
| COG0056 | F0F1-type ATP synthase, alpha subunit |
| COG0074 | Succinyl-CoA synthetase, alpha subunit |
| COG0114 | Fumarase |
| COG0221 | Inorganic pyrophosphatase |
| COG0224 | F0F1-type ATP synthase, gamma subunit |
| COG0240 | Glycerol-3-phosphate dehydrogenase |
| COG0243 | Anaerobic dehydrogenases, typically selenocysteine-containing |
| COG0247 | Fe-S oxidoreductase |
| COG0277 | FAD/FMN-containing dehydrogenases |
| COG0280 | Phosphotransacetylase |
| COG0281 | Malic enzyme |
| COG0282 | Acetate kinase |
| COG0348 | Polyferredoxin |
| COG0355 | F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) |
| COG0356 | F0F1-type ATP synthase, subunit a |
| COG0371 | Glycerol dehydrogenase and related enzymes |
| COG0372 | Citrate synthase |
| COG0374 | Ni,Fe-hydrogenase I large subunit |
| COG0377 | NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases |
| COG0426 | Uncharacterized flavoproteins |
| COG0427 | Acetyl-CoA hydrolase |
| COG0437 | Fe-S-cluster-containing hydrogenase components 1 |
| COG0473 | Isocitrate/isopropylmalate dehydrogenase |
| COG0479 | Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit |
| COG0508 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes |
| COG0526 | Thiol-disulfide isomerase and thioredoxins |
| COG0538 | Isocitrate dehydrogenases |
| COG0543 | 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases |
| COG0554 | Glycerol kinase |
| COG0567 | 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes |
| COG0578 | Glycerol-3-phosphate dehydrogenase |
| COG0584 | Glycerophosphoryl diester phosphodiesterase |
| COG0604 | NADPH:quinone reductase and related Zn-dependent oxidoreductases |
| COG0633 | Ferredoxin |
| COG0636 | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K |
| COG0644 | Dehydrogenases (flavoproteins) |
| COG0649 | NADH:ubiquinone oxidoreductase 49 kD subunit 7 |
| COG0650 | Formate hydrogenlyase subunit 4 |
| COG0651 | Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit |
| COG0654 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases |
| COG0667 | Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) |
| COG0674 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit |
| COG0680 | Ni,Fe-hydrogenase maturation factor |
| COG0711 | F0F1-type ATP synthase, subunit b |
| COG0712 | F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) |
| COG0713 | NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) |
| COG0716 | Flavodoxins |
| COG0723 | Rieske Fe-S protein |
| COG0731 | Fe-S oxidoreductases |
| COG0778 | Nitroreductase |
| COG0822 | NifU homolog involved in Fe-S cluster formation |
| COG0838 | NADH:ubiquinone oxidoreductase subunit 3 (chain A) |
| COG0839 | NADH:ubiquinone oxidoreductase subunit 6 (chain J) |
| COG0843 | Heme/copper-type cytochrome/quinol oxidases, subunit 1 |
| COG0852 | NADH:ubiquinone oxidoreductase 27 kD subunit |
| COG1005 | NADH:ubiquinone oxidoreductase subunit 1 (chain H) |
| COG1007 | NADH:ubiquinone oxidoreductase subunit 2 (chain N) |
| COG1008 | NADH:ubiquinone oxidoreductase subunit 4 (chain M) |
| COG1009 | NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit |
| COG1012 | NAD-dependent aldehyde dehydrogenases |
| COG1013 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit |
| COG1014 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit |
| COG1017 | Hemoglobin-like flavoprotein |
| COG1018 | Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 |
| COG1029 | Formylmethanofuran dehydrogenase subunit B |
| COG1031 | Uncharacterized Fe-S oxidoreductase |
| COG1032 | Fe-S oxidoreductase |
| COG1034 | NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) |
| COG1035 | Coenzyme F420-reducing hydrogenase, beta subunit |
| COG1036 | Archaeal flavoproteins |
| COG1038 | Pyruvate carboxylase |
| COG1042 | Acyl-CoA synthetase (NDP forming) |
| COG1048 | Aconitase A |
| COG1049 | Aconitase B |
| COG1052 | Lactate dehydrogenase and related dehydrogenases |
| COG1053 | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit |
| COG1062 | Zn-dependent alcohol dehydrogenases, class III |
| COG1069 | Ribulose kinase |
| COG1071 | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit |
| COG1085 | Galactose-1-phosphate uridylyltransferase |
| COG1139 | Uncharacterized conserved protein containing a ferredoxin-like domain |
| COG1140 | Nitrate reductase beta subunit |
| COG1141 | Ferredoxin |
| COG1142 | Fe-S-cluster-containing hydrogenase components 2 |
| COG1143 | Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) |
| COG1144 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit |
| COG1145 | Ferredoxin |
| COG1146 | Ferredoxin |
| COG1148 | Heterodisulfide reductase, subunit A and related polyferredoxins |
| COG1149 | MinD superfamily P-loop ATPase containing an inserted ferredoxin domain |
| COG1150 | Heterodisulfide reductase, subunit C |
| COG1151 | 6Fe-6S prismane cluster-containing protein |
| COG1152 | CO dehydrogenase/acetyl-CoA synthase alpha subunit |
| COG1153 | Formylmethanofuran dehydrogenase subunit D |
| COG1155 | Archaeal/vacuolar-type H+-ATPase subunit A |
| COG1156 | Archaeal/vacuolar-type H+-ATPase subunit B |
| COG1227 | Inorganic pyrophosphatase/exopolyphosphatase |
| COG1229 | Formylmethanofuran dehydrogenase subunit A |
| COG1249 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes |
| COG1251 | NAD(P)H-nitrite reductase |
| COG1252 | NADH dehydrogenase, FAD-containing subunit |
| COG1254 | Acylphosphatases |
| COG1269 | Archaeal/vacuolar-type H+-ATPase subunit I |
| COG1271 | Cytochrome bd-type quinol oxidase, subunit 1 |
| COG1274 | Phosphoenolpyruvate carboxykinase (GTP) |
| COG1282 | NAD/NADP transhydrogenase beta subunit |
| COG1290 | Cytochrome b subunit of the bc complex |
| COG1294 | Cytochrome bd-type quinol oxidase, subunit 2 |
| COG1301 | Na+/H+-dicarboxylate symporters |
| COG1304 | L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases |
| COG1319 | Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs |
| COG1347 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD |
| COG1390 | Archaeal/vacuolar-type H+-ATPase subunit E |
| COG1394 | Archaeal/vacuolar-type H+-ATPase subunit D |
| COG1413 | FOG: HEAT repeat |
| COG1436 | Archaeal/vacuolar-type H+-ATPase subunit F |
| COG1454 | Alcohol dehydrogenase, class IV |
| COG1456 | CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) |
| COG1526 | Uncharacterized protein required for formate dehydrogenase activity |
| COG1527 | Archaeal/vacuolar-type H+-ATPase subunit C |
| COG1529 | Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs |
| COG1592 | Rubrerythrin |
| COG1600 | Uncharacterized Fe-S protein |
| COG1614 | CO dehydrogenase/acetyl-CoA synthase beta subunit |
| COG1620 | L-lactate permease |
| COG1622 | Heme/copper-type cytochrome/quinol oxidases, subunit 2 |
| COG1625 | Fe-S oxidoreductase, related to NifB/MoaA family |
| COG1668 | ABC-type Na+ efflux pump, permease component |
| COG1726 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA |
| COG1740 | Ni,Fe-hydrogenase I small subunit |
| COG1757 | Na+/H+ antiporter |
| COG1773 | Rubredoxin |
| COG1804 | Predicted acyl-CoA transferases/carnitine dehydratase |
| COG1805 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB |
| COG1819 | Glycosyl transferases, related to UDP-glucuronosyltransferase |
| COG1838 | Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain |
| COG1845 | Heme/copper-type cytochrome/quinol oxidase, subunit 3 |
| COG1866 | Phosphoenolpyruvate carboxykinase (ATP) |
| COG1880 | CO dehydrogenase/acetyl-CoA synthase epsilon subunit |
| COG1882 | Pyruvate-formate lyase |
| COG1883 | Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit |
| COG1894 | NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit |
| COG1902 | NADH:flavin oxidoreductases, Old Yellow Enzyme family |
| COG1905 | NADH:ubiquinone oxidoreductase 24 kD subunit |
| COG1908 | Coenzyme F420-reducing hydrogenase, delta subunit |
| COG1927 | Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase |
| COG1941 | Coenzyme F420-reducing hydrogenase, gamma subunit |
| COG1951 | Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain |
| COG1969 | Ni,Fe-hydrogenase I cytochrome b subunit |
| COG1979 | Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family |
| COG2009 | Succinate dehydrogenase/fumarate reductase, cytochrome b subunit |
| COG2010 | Cytochrome c, mono- and diheme variants |
| COG2025 | Electron transfer flavoprotein, alpha subunit |
| COG2033 | Desulfoferrodoxin |
| COG2037 | Formylmethanofuran:tetrahydromethanopterin formyltransferase |
| COG2048 | Heterodisulfide reductase, subunit B |
| COG2055 | Malate/L-lactate dehydrogenases |
| COG2069 | CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) |
| COG2080 | Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs |
| COG2086 | Electron transfer flavoprotein, beta subunit |
| COG2141 | Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases |
| COG2142 | Succinate dehydrogenase, hydrophobic anchor subunit |
| COG2180 | Nitrate reductase delta subunit |
| COG2181 | Nitrate reductase gamma subunit |
| COG2191 | Formylmethanofuran dehydrogenase subunit E |
| COG2209 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE |
| COG2218 | Formylmethanofuran dehydrogenase subunit C |
| COG2221 | Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits |
| COG2224 | Isocitrate lyase |
| COG2225 | Malate synthase |
| COG2352 | Phosphoenolpyruvate carboxylase |
| COG2414 | Aldehyde:ferredoxin oxidoreductase |
| COG2421 | Predicted acetamidase/formamidase |
| COG2440 | Ferredoxin-like protein |
| COG2441 | Predicted butyrate kinase |
| COG2609 | Pyruvate dehydrogenase complex, dehydrogenase (E1) component |
| COG2710 | Nitrogenase molybdenum-iron protein, alpha and beta chains |
| COG2811 | Archaeal/vacuolar-type H+-ATPase subunit H |
| COG2838 | Monomeric isocitrate dehydrogenase |
| COG2851 | H+/citrate symporter |
| COG2857 | Cytochrome c1 |
| COG2863 | Cytochrome c553 |
| COG2864 | Cytochrome b subunit of formate dehydrogenase |
| COG2869 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC |
| COG2871 | Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF |
| COG2878 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfB |
| COG2924 | Fe-S cluster protector protein |
| COG2993 | Cbb3-type cytochrome oxidase, cytochrome c subunit |
| COG3005 | Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit |
| COG3029 | Fumarate reductase subunit C |
| COG3038 | Cytochrome B561 |
| COG3043 | Nitrate reductase cytochrome c-type subunit |
| COG3051 | Citrate lyase, alpha subunit |
| COG3052 | Citrate lyase, gamma subunit |
| COG3053 | Citrate lyase synthetase |
| COG3069 | C4-dicarboxylate transporter |
| COG3080 | Fumarate reductase subunit D |
| COG3125 | Heme/copper-type cytochrome/quinol oxidase, subunit 4 |
| COG3202 | ATP/ADP translocase |
| COG3241 | Azurin |
| COG3245 | Cytochrome c5 |
| COG3258 | Cytochrome c |
| COG3259 | Coenzyme F420-reducing hydrogenase, alpha subunit |
| COG3260 | Ni,Fe-hydrogenase III small subunit |
| COG3261 | Ni,Fe-hydrogenase III large subunit |
| COG3262 | Ni,Fe-hydrogenase III component G |
| COG3288 | NAD/NADP transhydrogenase alpha subunit |
| COG3312 | F0F1-type ATP synthase, subunit I |
| COG3411 | Ferredoxin |
| COG3426 | Butyrate kinase |
| COG3474 | Cytochrome c2 |
| COG3488 | Predicted thiol oxidoreductase |
| COG3493 | Na+/citrate symporter |
| COG3630 | Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit |
| COG3658 | Cytochrome b |
| COG3761 | NADH:ubiquinone oxidoreductase 17.2 kD subunit |
| COG3783 | Soluble cytochrome b562 |
| COG3794 | Plastocyanin |
| COG3808 | Inorganic pyrophosphatase |
| COG3909 | Cytochrome c556 |
| COG3954 | Phosphoribulokinase |
| COG4074 | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase |
| COG4117 | Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) |
| COG4229 | Predicted enolase-phosphatase |
| COG4230 | Delta 1-pyrroline-5-carboxylate dehydrogenase |
| COG4231 | Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits |
| COG4232 | Thiol:disulfide interchange protein |
| COG4233 | Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis |
| COG4237 | Hydrogenase 4 membrane component (E) |
| COG4263 | Nitrous oxide reductase |
| COG4313 | Protein involved in meta-pathway of phenol degradation |
| COG4314 | Predicted lipoprotein involved in nitrous oxide reduction |
| COG4451 | Ribulose bisphosphate carboxylase small subunit |
| COG4459 | Periplasmic nitrate reductase system, NapE component |
| COG4555 | ABC-type Na+ transport system, ATPase component |
| COG4576 | Carbon dioxide concentrating mechanism/carboxysome shell protein |
| COG4577 | Carbon dioxide concentrating mechanism/carboxysome shell protein |
| COG4635 | Flavodoxin |
| COG4654 | Cytochrome c551/c552 |
| COG4656 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfC |
| COG4657 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfA |
| COG4658 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfD |
| COG4659 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfG |
| COG4660 | Predicted NADH:ubiquinone oxidoreductase, subunit RnfE |
| COG4781 | Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase |
| COG4802 | Ferredoxin-thioredoxin reductase, catalytic subunit |
| COG4987 | ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components |
| COG4988 | ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components |
| COG5013 | Nitrate reductase alpha subunit |
| COG5016 | Pyruvate/oxaloacetate carboxyltransferase |
| COG5127 | Vacuolar H+-ATPase V1 sector, subunit C |
| COG5231 | Vacuolar H+-ATPase V1 sector, subunit H |
| COG5274 | Cytochrome b involved in lipid metabolism |
| COG5557 | Polysulphide reductase |
