| COG0002 | Acetylglutamate semialdehyde dehydrogenase |
| COG0006 | Xaa-Pro aminopeptidase |
| COG0010 | Arginase/agmatinase/formimionoglutamate hydrolase, arginase family |
| COG0014 | Gamma-glutamyl phosphate reductase |
| COG0019 | Diaminopimelate decarboxylase |
| COG0028 | Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] |
| COG0031 | Cysteine synthase |
| COG0040 | ATP phosphoribosyltransferase |
| COG0059 | Ketol-acid reductoisomerase |
| COG0065 | 3-isopropylmalate dehydratase large subunit |
| COG0066 | 3-isopropylmalate dehydratase small subunit |
| COG0067 | Glutamate synthase domain 1 |
| COG0069 | Glutamate synthase domain 2 |
| COG0070 | Glutamate synthase domain 3 |
| COG0075 | Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase |
| COG0076 | Glutamate decarboxylase and related PLP-dependent proteins |
| COG0077 | Prephenate dehydratase |
| COG0078 | Ornithine carbamoyltransferase |
| COG0079 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase |
| COG0082 | Chorismate synthase |
| COG0083 | Homoserine kinase |
| COG0106 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase |
| COG0107 | Imidazoleglycerol-phosphate synthase |
| COG0111 | Phosphoglycerate dehydrogenase and related dehydrogenases |
| COG0112 | Glycine/serine hydroxymethyltransferase |
| COG0115 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase |
| COG0118 | Glutamine amidotransferase |
| COG0119 | Isopropylmalate/homocitrate/citramalate synthases |
| COG0128 | 5-enolpyruvylshikimate-3-phosphate synthase |
| COG0129 | Dihydroxyacid dehydratase/phosphogluconate dehydratase |
| COG0131 | Imidazoleglycerol-phosphate dehydratase |
| COG0133 | Tryptophan synthase beta chain |
| COG0134 | Indole-3-glycerol phosphate synthase |
| COG0135 | Phosphoribosylanthranilate isomerase |
| COG0136 | Aspartate-semialdehyde dehydrogenase |
| COG0137 | Argininosuccinate synthase |
| COG0139 | Phosphoribosyl-AMP cyclohydrolase |
| COG0140 | Phosphoribosyl-ATP pyrophosphohydrolase |
| COG0141 | Histidinol dehydrogenase |
| COG0145 | N-methylhydantoinase A/acetone carboxylase, beta subunit |
| COG0146 | N-methylhydantoinase B/acetone carboxylase, alpha subunit |
| COG0147 | Anthranilate/para-aminobenzoate synthases component I |
| COG0159 | Tryptophan synthase alpha chain |
| COG0160 | 4-aminobutyrate aminotransferase and related aminotransferases |
| COG0165 | Argininosuccinate lyase |
| COG0169 | Shikimate 5-dehydrogenase |
| COG0174 | Glutamine synthetase |
| COG0175 | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes |
| COG0241 | Histidinol phosphatase and related phosphatases |
| COG0252 | L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D |
| COG0253 | Diaminopimelate epimerase |
| COG0260 | Leucyl aminopeptidase |
| COG0263 | Glutamate 5-kinase |
| COG0287 | Prephenate dehydrogenase |
| COG0289 | Dihydrodipicolinate reductase |
| COG0308 | Aminopeptidase N |
| COG0329 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase |
| COG0334 | Glutamate dehydrogenase/leucine dehydrogenase |
| COG0337 | 3-dehydroquinate synthetase |
| COG0339 | Zn-dependent oligopeptidases |
| COG0345 | Pyrroline-5-carboxylate reductase |
| COG0346 | Lactoylglutathione lyase and related lyases |
| COG0347 | Nitrogen regulatory protein PII |
| COG0367 | Asparagine synthase (glutamine-hydrolyzing) |
| COG0403 | Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain |
| COG0404 | Glycine cleavage system T protein (aminomethyltransferase) |
| COG0405 | Gamma-glutamyltransferase |
| COG0410 | ABC-type branched-chain amino acid transport systems, ATPase component |
| COG0411 | ABC-type branched-chain amino acid transport systems, ATPase component |
| COG0421 | Spermidine synthase |
| COG0436 | Aspartate/tyrosine/aromatic aminotransferase |
| COG0440 | Acetolactate synthase, small (regulatory) subunit |
| COG0444 | ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component |
| COG0458 | Carbamoylphosphate synthase large subunit (split gene in MJ) |
| COG0460 | Homoserine dehydrogenase |
| COG0462 | Phosphoribosylpyrophosphate synthetase |
| COG0473 | Isocitrate/isopropylmalate dehydrogenase |
| COG0477 | Permeases of the major facilitator superfamily |
| COG0493 | NADPH-dependent glutamate synthase beta chain and related oxidoreductases |
| COG0498 | Threonine synthase |
| COG0505 | Carbamoylphosphate synthase small subunit |
| COG0506 | Proline dehydrogenase |
| COG0509 | Glycine cleavage system H protein (lipoate-binding) |
| COG0512 | Anthranilate/para-aminobenzoate synthases component II |
| COG0520 | Selenocysteine lyase |
| COG0527 | Aspartokinases |
| COG0531 | Amino acid transporters |
| COG0547 | Anthranilate phosphoribosyltransferase |
| COG0548 | Acetylglutamate kinase |
| COG0549 | Carbamate kinase |
| COG0559 | Branched-chain amino acid ABC-type transport system, permease components |
| COG0560 | Phosphoserine phosphatase |
| COG0591 | Na+/proline symporter |
| COG0601 | ABC-type dipeptide/oligopeptide/nickel transport systems, permease components |
| COG0620 | Methionine synthase II (cobalamin-independent) |
| COG0624 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases |
| COG0626 | Cystathionine beta-lyases/cystathionine gamma-synthases |
| COG0646 | Methionine synthase I (cobalamin-dependent), methyltransferase domain |
| COG0665 | Glycine/D-amino acid oxidases (deaminating) |
| COG0683 | ABC-type branched-chain amino acid transport systems, periplasmic component |
| COG0685 | 5,10-methylenetetrahydrofolate reductase |
| COG0686 | Alanine dehydrogenase |
| COG0687 | Spermidine/putrescine-binding periplasmic protein |
| COG0697 | Permeases of the drug/metabolite transporter (DMT) superfamily |
| COG0703 | Shikimate kinase |
| COG0709 | Selenophosphate synthase |
| COG0710 | 3-dehydroquinate dehydratase |
| COG0722 | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase |
| COG0747 | ABC-type dipeptide transport system, periplasmic component |
| COG0754 | Glutathionylspermidine synthase |
| COG0757 | 3-dehydroquinate dehydratase II |
| COG0765 | ABC-type amino acid transport system, permease component |
| COG0786 | Na+/glutamate symporter |
| COG0804 | Urea amidohydrolase (urease) alpha subunit |
| COG0814 | Amino acid permeases |
| COG0831 | Urea amidohydrolase (urease) gamma subunit |
| COG0832 | Urea amidohydrolase (urease) beta subunit |
| COG0833 | Amino acid transporters |
| COG0834 | ABC-type amino acid transport/signal transduction systems, periplasmic component/domain |
| COG1003 | Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain |
| COG1027 | Aspartate ammonia-lyase |
| COG1045 | Serine acetyltransferase |
| COG1063 | Threonine dehydrogenase and related Zn-dependent dehydrogenases |
| COG1104 | Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes |
| COG1113 | Gamma-aminobutyrate permease and related permeases |
| COG1114 | Branched-chain amino acid permeases |
| COG1115 | Na+/alanine symporter |
| COG1124 | ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component |
| COG1125 | ABC-type proline/glycine betaine transport systems, ATPase components |
| COG1126 | ABC-type polar amino acid transport system, ATPase component |
| COG1164 | Oligoendopeptidase F |
| COG1166 | Arginine decarboxylase (spermidine biosynthesis) |
| COG1167 | Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs |
| COG1168 | Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities |
| COG1171 | Threonine dehydratase |
| COG1173 | ABC-type dipeptide/oligopeptide/nickel transport systems, permease components |
| COG1174 | ABC-type proline/glycine betaine transport systems, permease component |
| COG1176 | ABC-type spermidine/putrescine transport system, permease component I |
| COG1177 | ABC-type spermidine/putrescine transport system, permease component II |
| COG1231 | Monoamine oxidase |
| COG1246 | N-acetylglutamate synthase and related acetyltransferases |
| COG1280 | Putative threonine efflux protein |
| COG1296 | Predicted branched-chain amino acid permease (azaleucine resistance) |
| COG1305 | Transglutaminase-like enzymes, putative cysteine proteases |
| COG1362 | Aspartyl aminopeptidase |
| COG1364 | N-acetylglutamate synthase (N-acetylornithine aminotransferase) |
| COG1387 | Histidinol phosphatase and related hydrolases of the PHP family |
| COG1410 | Methionine synthase I, cobalamin-binding domain |
| COG1446 | Asparaginase |
| COG1448 | Aspartate/tyrosine/aromatic aminotransferase |
| COG1465 | Predicted alternative 3-dehydroquinate synthase |
| COG1505 | Serine proteases of the peptidase family S9A |
| COG1506 | Dipeptidyl aminopeptidases/acylaminoacyl-peptidases |
| COG1509 | Lysine 2,3-aminomutase |
| COG1586 | S-adenosylmethionine decarboxylase |
| COG1605 | Chorismate mutase |
| COG1685 | Archaeal shikimate kinase |
| COG1687 | Predicted branched-chain amino acid permeases (azaleucine resistance) |
| COG1703 | Putative periplasmic protein kinase ArgK and related GTPases of G3E family |
| COG1748 | Saccharopine dehydrogenase and related proteins |
| COG1760 | L-serine deaminase |
| COG1770 | Protease II |
| COG1775 | Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB |
| COG1812 | Archaeal S-adenosylmethionine synthetase |
| COG1834 | N-Dimethylarginine dimethylaminohydrolase |
| COG1897 | Homoserine trans-succinylase |
| COG1921 | Selenocysteine synthase [seryl-tRNASer selenium transferase] |
| COG1932 | Phosphoserine aminotransferase |
| COG1982 | Arginine/lysine/ornithine decarboxylases |
| COG1984 | Allophanate hydrolase subunit 2 |
| COG2008 | Threonine aldolase |
| COG2021 | Homoserine acetyltransferase |
| COG2040 | Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) |
| COG2049 | Allophanate hydrolase subunit 1 |
| COG2061 | ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase |
| COG2066 | Glutaminase |
| COG2113 | ABC-type proline/glycine betaine transport systems, periplasmic components |
| COG2171 | Tetrahydrodipicolinate N-succinyltransferase |
| COG2195 | Di- and tripeptidases |
| COG2235 | Arginine deiminase |
| COG2303 | Choline dehydrogenase and related flavoproteins |
| COG2309 | Leucyl aminopeptidase (aminopeptidase T) |
| COG2317 | Zn-dependent carboxypeptidase |
| COG2355 | Zn-dependent dipeptidase, microsomal dipeptidase homolog |
| COG2362 | D-aminopeptidase |
| COG2423 | Predicted ornithine cyclodeaminase, mu-crystallin homolog |
| COG2502 | Asparagine synthetase A |
| COG2515 | 1-aminocyclopropane-1-carboxylate deaminase |
| COG2610 | H+/gluconate symporter and related permeases |
| COG2716 | Glycine cleavage system regulatory protein |
| COG2755 | Lysophospholipase L1 and related esterases |
| COG2856 | Predicted Zn peptidase |
| COG2866 | Predicted carboxypeptidase |
| COG2873 | O-acetylhomoserine sulfhydrylase |
| COG2876 | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase |
| COG2902 | NAD-specific glutamate dehydrogenase |
| COG2939 | Carboxypeptidase C (cathepsin A) |
| COG2957 | Peptidylarginine deiminase and related enzymes |
| COG2981 | Uncharacterized protein involved in cysteine biosynthesis |
| COG2986 | Histidine ammonia-lyase |
| COG2987 | Urocanate hydratase |
| COG2988 | Succinylglutamate desuccinylase |
| COG3033 | Tryptophanase |
| COG3048 | D-serine dehydratase |
| COG3060 | Transcriptional regulator of met regulon |
| COG3075 | Anaerobic glycerol-3-phosphate dehydrogenase |
| COG3104 | Dipeptide/tripeptide permease |
| COG3138 | Arginine/ornithine N-succinyltransferase beta subunit |
| COG3185 | 4-hydroxyphenylpyruvate dioxygenase and related hemolysins |
| COG3186 | Phenylalanine-4-hydroxylase |
| COG3191 | L-aminopeptidase/D-esterase |
| COG3192 | Ethanolamine utilization protein |
| COG3200 | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase |
| COG3227 | Zinc metalloprotease (elastase) |
| COG3232 | 5-carboxymethyl-2-hydroxymuconate isomerase |
| COG3283 | Transcriptional regulator of aromatic amino acids metabolism |
| COG3340 | Peptidase E |
| COG3404 | Methenyl tetrahydrofolate cyclohydrolase |
| COG3457 | Predicted amino acid racemase |
| COG3483 | Tryptophan 2,3-dioxygenase (vermilion) |
| COG3579 | Aminopeptidase C |
| COG3591 | V8-like Glu-specific endopeptidase |
| COG3616 | Predicted amino acid aldolase or racemase |
| COG3633 | Na+/serine symporter |
| COG3643 | Glutamate formiminotransferase |
| COG3705 | ATP phosphoribosyltransferase involved in histidine biosynthesis |
| COG3724 | Succinylarginine dihydrolase |
| COG3741 | N-formylglutamate amidohydrolase |
| COG3799 | Methylaspartate ammonia-lyase |
| COG3842 | ABC-type spermidine/putrescine transport systems, ATPase components |
| COG3844 | Kynureninase |
| COG3869 | Arginine kinase |
| COG3931 | Predicted N-formylglutamate amidohydrolase |
| COG3938 | Proline racemase |
| COG3962 | Acetolactate synthase |
| COG3977 | Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase |
| COG4091 | Predicted homoserine dehydrogenase |
| COG4126 | Hydantoin racemase |
| COG4160 | ABC-type arginine/histidine transport system, permease component |
| COG4161 | ABC-type arginine transport system, ATPase component |
| COG4166 | ABC-type oligopeptide transport system, periplasmic component |
| COG4175 | ABC-type proline/glycine betaine transport system, ATPase component |
| COG4176 | ABC-type proline/glycine betaine transport system, permease component |
| COG4177 | ABC-type branched-chain amino acid transport system, permease component |
| COG4187 | Arginine degradation protein (predicted deacylase) |
| COG4215 | ABC-type arginine transport system, permease component |
| COG4302 | Ethanolamine ammonia-lyase, small subunit |
| COG4303 | Ethanolamine ammonia-lyase, large subunit |
| COG4311 | Sarcosine oxidase delta subunit |
| COG4359 | Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling |
| COG4362 | Nitric oxide synthase, oxygenase domain |
| COG4401 | Chorismate mutase |
| COG4413 | Urea transporter |
| COG4448 | L-asparaginase II |
| COG4583 | Sarcosine oxidase gamma subunit |
| COG4597 | ABC-type amino acid transport system, permease component |
| COG4598 | ABC-type histidine transport system, ATPase component |
| COG4608 | ABC-type oligopeptide transport system, ATPase component |
| COG4690 | Dipeptidase |
| COG4766 | Ethanolamine utilization protein |
| COG4810 | Ethanolamine utilization protein |
| COG4812 | Ethanolamine utilization cobalamin adenosyltransferase |
| COG4816 | Ethanolamine utilization protein |
| COG4819 | Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition |
| COG4820 | Ethanolamine utilization protein, possible chaperonin |
| COG4865 | Glutamate mutase epsilon subunit |
| COG4917 | Ethanolamine utilization protein |
| COG4992 | Ornithine/acetylornithine aminotransferase |
| COG5425 | Usg protein, probable subunit of phosphoribosylanthranilate isomerase |
| COG5630 | Acetylglutamate synthase |
