| COG0123 | Deacetylases, including yeast histone deacetylase and acetoin utilization protein |
| COG0145 | N-methylhydantoinase A/acetone carboxylase, beta subunit |
| COG0146 | N-methylhydantoinase B/acetone carboxylase, alpha subunit |
| COG0179 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) |
| COG0236 | Acyl carrier protein |
| COG0304 | 3-oxoacyl-(acyl-carrier-protein) synthase |
| COG0318 | Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II |
| COG0412 | Dienelactone hydrolase and related enzymes |
| COG0500 | SAM-dependent methyltransferases |
| COG0767 | ABC-type transport system involved in resistance to organic solvents, permease component |
| COG1020 | Non-ribosomal peptide synthetase modules and related proteins |
| COG1021 | Peptide arylation enzymes |
| COG1028 | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) |
| COG1127 | ABC-type transport system involved in resistance to organic solvents, ATPase component |
| COG1169 | Isochorismate synthase |
| COG1228 | Imidazolonepropionase and related amidohydrolases |
| COG1233 | Phytoene dehydrogenase and related proteins |
| COG1335 | Amidases related to nicotinamidase |
| COG1463 | ABC-type transport system involved in resistance to organic solvents, periplasmic component |
| COG1535 | Isochorismate hydrolase |
| COG2015 | Alkyl sulfatase and related hydrolases |
| COG2050 | Uncharacterized protein, possibly involved in aromatic compounds catabolism |
| COG2124 | Cytochrome P450 |
| COG2132 | Putative multicopper oxidases |
| COG2162 | Arylamine N-acetyltransferase |
| COG2175 | Probable taurine catabolism dioxygenase |
| COG2313 | Uncharacterized enzyme involved in pigment biosynthesis |
| COG2368 | Aromatic ring hydroxylase |
| COG2508 | Regulator of polyketide synthase expression |
| COG2761 | Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis |
| COG2854 | ABC-type transport system involved in resistance to organic solvents, auxiliary component |
| COG2931 | RTX toxins and related Ca2+-binding proteins |
| COG2977 | Phosphopantetheinyl transferase component of siderophore synthetase |
| COG3127 | Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component |
| COG3135 | Uncharacterized protein involved in benzoate metabolism |
| COG3155 | Uncharacterized protein involved in an early stage of isoprenoid biosynthesis |
| COG3191 | L-aminopeptidase/D-esterase |
| COG3207 | Pyoverdine/dityrosine biosynthesis protein |
| COG3208 | Predicted thioesterase involved in non-ribosomal peptide biosynthesis |
| COG3284 | Transcriptional activator of acetoin/glycerol metabolism |
| COG3315 | O-Methyltransferase involved in polyketide biosynthesis |
| COG3319 | Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases |
| COG3320 | Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes |
| COG3321 | Polyketide synthase modules and related proteins |
| COG3424 | Predicted naringenin-chalcone synthase |
| COG3433 | Aryl carrier domain |
| COG3435 | Gentisate 1,2-dioxygenase |
| COG3458 | Acetyl esterase (deacetylase) |
| COG3460 | Uncharacterized enzyme of phenylacetate metabolism |
| COG3473 | Maleate cis-trans isomerase |
| COG3479 | Phenolic acid decarboxylase |
| COG3485 | Protocatechuate 3,4-dioxygenase beta subunit |
| COG3486 | Lysine/ornithine N-monooxygenase |
| COG3508 | Homogentisate 1,2-dioxygenase |
| COG3509 | Poly(3-hydroxybutyrate) depolymerase |
| COG3527 | Alpha-acetolactate decarboxylase |
| COG3648 | Uricase (urate oxidase) |
| COG3653 | N-acyl-D-aspartate/D-glutamate deacylase |
| COG3670 | Lignostilbene-alpha,beta-dioxygenase and related enzymes |
| COG3733 | Cu2+-containing amine oxidase |
| COG3805 | Aromatic ring-cleaving dioxygenase |
| COG3882 | Predicted enzyme involved in methoxymalonyl-ACP biosynthesis |
| COG3916 | N-acyl-L-homoserine lactone synthetase |
| COG3917 | 2-hydroxychromene-2-carboxylate isomerase |
| COG3971 | 2-keto-4-pentenoate hydratase |
| COG4181 | Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component |
| COG4242 | Cyanophycinase and related exopeptidases |
| COG4264 | Siderophore synthetase component |
| COG4308 | Limonene-1,2-epoxide hydrolase |
| COG4542 | Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase |
| COG4569 | Acetaldehyde dehydrogenase (acetylating) |
| COG4576 | Carbon dioxide concentrating mechanism/carboxysome shell protein |
| COG4577 | Carbon dioxide concentrating mechanism/carboxysome shell protein |
| COG4615 | ABC-type siderophore export system, fused ATPase and permease components |
| COG4647 | Acetone carboxylase, gamma subunit |
| COG4663 | TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component |
| COG4664 | TRAP-type mannitol/chloroaromatic compound transport system, large permease component |
| COG4665 | TRAP-type mannitol/chloroaromatic compound transport system, small permease component |
| COG4689 | Acetoacetate decarboxylase |
| COG4693 | Oxidoreductase (NAD-binding), involved in siderophore biosynthesis |
| COG4829 | Muconolactone delta-isomerase |
| COG4869 | Propanediol utilization protein |
| COG4909 | Propanediol dehydratase, large subunit |
| COG4910 | Propanediol dehydratase, small subunit |
| COG5285 | Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin |
| COG5310 | Homospermidine synthase |
| COG5517 | Small subunit of phenylpropionate dioxygenase |
| COG5554 | Nitrogen fixation protein |
