oxidized purine base lesion DNA N-glycosylase activity
name: oxidized purine base lesion DNA N-glycosylase activity
Description: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
|GO:0034039||8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|
|GO:0000702||oxidized base lesion DNA N-glycosylase activity|
|GO:0003906||DNA-(apurinic or apyrimidinic site) lyase activity|