oxidized purine base lesion DNA N-glycosylase activity

id: GO:0008534
name: oxidized purine base lesion DNA N-glycosylase activity
namespace: molecular_function
type: go
obsolete: False

Description: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.

Child Functions

idname
GO:00340398-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Parent Functions

idname
GO:0000702oxidized base lesion DNA N-glycosylase activity
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity