THO complex

id: GO:0000347
name: THO complex
namespace: cellular_component
type: go
obsolete: False

Description: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.

Child Functions

GO:0000445THO complex part of transcription export complex
GO:0000446nucleoplasmic THO complex

Parent Functions

GO:0043234protein complex
GO:0044428nuclear part