protein-glutamine gamma-glutamyltransferase activity

id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
type: go
obsolete: False

Description: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.

Parent Functions

GO:0016755transferase activity, transferring amino-acyl groups