BRCA1-C complex

id: GO:0070533
name: BRCA1-C complex
namespace: cellular_component
type: go
obsolete: False

Description: A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.

Parent Functions

GO:0043234protein complex
GO:0044428nuclear part