MSMEG_5049 MSMEG_5049 Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

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Summary
Locus Tag Symbol Synonyms Product Protein Synonyms Start End Strand PubMed ID
MSMEG_5049 MSMEG_5049 kgd kgd, sucA, MSMEG_5049, MSMEI_4922 Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] 17295914, 18955433, 19019160, 21867916
Regulatory Modules
Residual Expression Plot
msm_bicluster_0074 0.50
msm_bicluster_0542 0.44
XReference
Mutations
Transposon mutants
Title Insert TAG Module
NA
Homology
Orthologues Paralogues
Functions
Catalytic Activity KEGG Ontology Pathways
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO(2), ECO:0000269|PubMed:21867916}.; 2-oxoglutarate = succinate semialdehyde + CO(2), ECO:0000269|PubMed:21867916}.; 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2), ECO:0000269|PubMed:21867916}.; Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine, ECO:0000269|PubMed:21867916}. msb:LJ00_24970, msg:MSMEI_4922, msm:MSMEG_5049 Carbohydrate metabolism, tricarboxylic acid cycle, succinate from 2-oxoglutarate (transferase route): step 1/2. {ECO:0000269|PubMed:21867916}., Carbohydrate metabolism, tricarboxylic acid cycle, succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1. {ECO:0000269|PubMed:21867916}.
Product Synonyms
Product (LegacyBRC) Product (RefSeq)
Operon
Refseq
GI Number Accession Blast Conserved Domains
GO Terms
String Network
Link to STRINGS STRINGS Network
MSMEG_5049
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