Tnf tumor necrosis factor (21926)

Symbol Product Feature Type Strand Chr
21926 Tnf tumor necrosis factor protein-coding 17
Synonyms
DIF | TNF-a | TNF-alpha | TNFSF2 | TNFalpha | Tnfa | Tnfsf1a
GO ID Category Definition Evidence
  • protein import into nucleus, translocation
  • negative regulation of transcription from RNA polymerase II promoter
  • MAPK cascade
  • activation of MAPKKK activity
  • activation of MAPK activity
  • cell activation
  • positive regulation of cytokine production
  • phagocytic cup
  • regulation of protein phosphorylation
  • positive regulation of protein phosphorylation
  • protease binding
  • negative regulation of L-glutamate transport
  • chronic inflammatory response to antigenic stimulus
  • negative regulation of cytokine secretion involved in immune response
  • positive regulation of chronic inflammatory response to antigenic stimulus
  • positive regulation of humoral immune response mediated by circulating immunoglobulin
  • cytokine activity
  • tumor necrosis factor receptor binding
  • protein binding
  • extracellular region
  • extracellular space
  • intracellular
  • plasma membrane
  • integral component of plasma membrane
  • glucose metabolic process
  • apoptotic process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • transformed cell apoptotic process
  • defense response
  • inflammatory response
  • immune response
  • humoral immune response
  • signal transduction
  • JNK cascade
  • multicellular organismal development
  • cell proliferation
  • positive regulation of cell proliferation
  • negative regulation of cell proliferation
  • extrinsic apoptotic signaling pathway via death domain receptors
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • cellular amino acid biosynthetic process
  • response to virus
  • organ morphogenesis
  • external side of plasma membrane
  • cell surface
  • negative regulation of gene expression
  • negative regulation of alkaline phosphatase activity
  • membrane
  • integral component of membrane
  • calcium-mediated signaling
  • secretory granule
  • extracellular matrix organization
  • osteoclast differentiation
  • sequestering of triglyceride
  • positive regulation of protein complex assembly
  • positive regulation of fever generation
  • lipopolysaccharide-mediated signaling pathway
  • negative regulation of interleukin-6 production
  • positive regulation of chemokine production
  • positive regulation of interferon-gamma production
  • positive regulation of interleukin-18 production
  • positive regulation of interleukin-6 production
  • receptor biosynthetic process
  • positive regulation of peptidyl-serine phosphorylation
  • tumor necrosis factor-mediated signaling pathway
  • positive regulation of heterotypic cell-cell adhesion
  • regulation of cell proliferation
  • positive regulation of NF-kappaB import into nucleus
  • defense response to bacterium
  • identical protein binding
  • positive regulation of apoptotic process
  • positive regulation of programmed cell death
  • regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • negative regulation of protein complex disassembly
  • positive regulation of protein complex disassembly
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of MAP kinase activity
  • protein kinase B signaling
  • positive regulation of JUN kinase activity
  • positive regulation of neuron apoptotic process
  • negative regulation of growth of symbiont in host
  • transcription regulatory region DNA binding
  • negative regulation of viral genome replication
  • positive regulation of chemokine biosynthetic process
  • membrane raft
  • cellular extravasation
  • positive regulation of interleukin-8 biosynthetic process
  • positive regulation of nitric oxide biosynthetic process
  • negative regulation of osteoblast differentiation
  • regulation of osteoclast differentiation
  • positive regulation of osteoclast differentiation
  • positive regulation of action potential
  • positive regulation of mitosis
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of translational initiation by iron
  • negative regulation of glucose import
  • positive regulation of JNK cascade
  • positive regulation of smooth muscle cell proliferation
  • regulation of protein secretion
  • positive regulation of cytokine secretion
  • positive regulation of inflammatory response
  • regulation of insulin secretion
  • positive regulation of synaptic transmission
  • defense response to Gram-positive bacterium
  • leukocyte migration
  • leukocyte tethering or rolling
  • detection of mechanical stimulus involved in sensory perception of pain
  • negative regulation of lipid catabolic process
  • regulation of immunoglobulin secretion
  • positive regulation of membrane protein ectodomain proteolysis
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of protein transport
  • response to glucocorticoid
  • positive regulation of NFAT protein import into nucleus
  • positive regulation of hair follicle development
  • positive regulation of protein kinase B signaling
  • recycling endosome
  • positive regulation of vitamin D biosynthetic process
  • positive regulation of calcidiol 1-monooxygenase activity
  • epithelial cell proliferation involved in salivary gland morphogenesis
  • regulation of branching involved in salivary gland morphogenesis
  • negative regulation of branching involved in lung morphogenesis
  • necrotic cell death
  • cellular response to amino acid stimulus
  • cellular response to nicotine
  • cellular response to organic cyclic compound
  • positive regulation of podosome assembly
  • apoptotic signaling pathway
  • extrinsic apoptotic signaling pathway
  • necroptotic signaling pathway
  • positive regulation of protein localization to cell surface
  • positive regulation of chemokine (C-X-C motif) ligand 2 production
  • regulation of reactive oxygen species metabolic process
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Motif 1 Motif 2 Residual
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Entrez ID STRINGS Network
STRING
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