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- cell cycle checkpoint
- DNA damage checkpoint
- MAPK cascade
- nucleotide binding
- activation of MAPKK activity
- magnesium ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- MAP kinase kinase kinase activity
- ATP binding
- nucleus
- cytoplasm
- protein phosphorylation
- cytoskeleton organization
- cell cycle
- cell cycle arrest
- activation of JUN kinase activity
- response to radiation
- kinase activity
- phosphorylation
- transferase activity
- transferase activity, transferring phosphorus-containing groups
- intracellular signal transduction
- positive regulation of apoptotic process
- metal ion binding
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