Sirt1 sirtuin 1 (93759)

Symbol Product Feature Type Strand Chr
93759 Sirt1 sirtuin 1 protein-coding 10
Synonyms
AA673258 | SIR2L1 | Sir2 | Sir2a | Sir2alpha
GO ID Category Definition Evidence
  • single strand break repair
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • pyrimidine dimer repair by nucleotide-excision repair
  • DNA synthesis involved in DNA repair
  • chromatin
  • nuclear chromatin
  • angiogenesis
  • ovulation from ovarian follicle
  • cellular glucose homeostasis
  • positive regulation of protein phosphorylation
  • p53 binding
  • positive regulation of adaptive immune response
  • transcription corepressor activity
  • histone deacetylase activity
  • protein binding
  • nucleus
  • nuclear envelope
  • nuclear inner membrane
  • nucleoplasm
  • chromatin silencing complex
  • nuclear euchromatin
  • nuclear heterochromatin
  • cytoplasm
  • mitochondrion
  • establishment of chromatin silencing
  • maintenance of chromatin silencing
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • rRNA processing
  • protein deacetylation
  • triglyceride mobilization
  • apoptotic process
  • cellular response to DNA damage stimulus
  • response to oxidative stress
  • multicellular organismal development
  • spermatogenesis
  • regulation of mitotic cell cycle
  • muscle organ development
  • protein C-terminus binding
  • positive regulation of cell proliferation
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • cellular response to starvation
  • positive regulation of cholesterol efflux
  • regulation of glucose metabolic process
  • positive regulation of macroautophagy
  • protein ubiquitination
  • histone deacetylation
  • PML body
  • hydrolase activity
  • NAD-dependent histone deacetylase activity
  • peptidyl-lysine acetylation
  • deacetylase activity
  • enzyme binding
  • protein domain specific binding
  • cell differentiation
  • negative regulation of cell growth
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • negative regulation of prostaglandin biosynthetic process
  • protein destabilization
  • positive regulation of chromatin silencing
  • negative regulation of TOR signaling
  • regulation of endodeoxyribonuclease activity
  • negative regulation of NF-kappaB transcription factor activity
  • response to insulin
  • regulation of protein import into nucleus, translocation
  • rDNA heterochromatin
  • protein deacetylase activity
  • regulation of smooth muscle cell apoptotic process
  • NAD-dependent protein deacetylase activity
  • peptidyl-lysine deacetylation
  • ESC/E(Z) complex
  • cellular triglyceride homeostasis
  • regulation of peroxisome proliferator activated receptor signaling pathway
  • regulation of cell proliferation
  • negative regulation of phosphorylation
  • histone binding
  • response to hydrogen peroxide
  • cholesterol homeostasis
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • identical protein binding
  • positive regulation of apoptotic process
  • negative regulation of apoptotic process
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • HLH domain binding
  • bHLH transcription factor binding
  • negative regulation of sequence-specific DNA binding transcription factor activity
  • negative regulation of DNA damage response, signal transduction by p53 class mediator
  • positive regulation of MHC class II biosynthetic process
  • negative regulation of fat cell differentiation
  • positive regulation of DNA repair
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of insulin receptor signaling pathway
  • metal ion binding
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
  • white fat cell differentiation
  • mitogen-activated protein kinase binding
  • negative regulation of helicase activity
  • negative regulation of protein kinase B signaling
  • fatty acid homeostasis
  • negative regulation of androgen receptor signaling pathway
  • cellular response to hydrogen peroxide
  • NAD+ binding
  • regulation of bile acid biosynthetic process
  • histone H3 deacetylation
  • cellular response to tumor necrosis factor
  • cellular response to hypoxia
  • cellular response to ionizing radiation
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
  • positive regulation of macrophage apoptotic process
  • negative regulation of cAMP-dependent protein kinase activity
  • positive regulation of cAMP-dependent protein kinase activity
  • negative regulation of cellular response to testosterone stimulus
  • negative regulation of peptidyl-lysine acetylation
  • negative regulation of cellular senescence
  • positive regulation of cellular senescence
  • regulation of RNA biosynthetic process
Motif 1 Motif 2 Residual
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Entrez ID STRINGS Network
STRING
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