TargetScan_125 megaCluster: 11 Residual: 0.23

Summary

Title	Cluster	Residual	Bicluster Conditions	Residual Permutation P-Value	Var. Exp. First PC	Var. Exp. First PC Perm. P-Value
TargetScan_125	11	0.23	12	0	0.786008	0.007

Members

Displaying 1 - 41 of 41

TFBS DB TF

TFs	percTargets	pValue
V_NFY_01_M00287	0.463415	0.0000104

GO Terms

Displaying 1 - 1 of 1

GO Terms
NA

Upstream MEME Motif

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif2 E-Value	Motif2 Consensus	Motif2 Matches
0.44	RARAAAAMWAAA	IRF1_MA0050.1, STAT1_MA0137.1	2.9	GGGGCGGGGCY	Klf4_MA0039.2, SP1_MA0079.2, SP1_MA0079.1, V$SP1_Q6_M00196, V$SP1_Q6_01_M00931, V$GC_01_M00255, V$SP1_Q4_01_M00932, V$SP4_Q5_M01273, V$SP1_Q2_01_M00933, V$KLF7_03_M02773, V$SP2_01_M01783, V$SP4_03_M02810, V$SP1_02_M01303, V$SP1_01_M00008, V$GKLF_02_M01588, V$E2F3_Q6_M02089, V$SP1_03_M02281, V$UF1H3BETA_Q6_M01068, V$ZFP281_01_M01597, V$SMAD4_04_M02898, V$MAZR_01_M00491, V$BCL6B_04_M02844, V$CKROX_Q2_M01175, V$KROX_Q6_M00982, V$EGR1_Q6_M01873, V$EGR1_06_M02744, V$SP4_04_M02914, V$CACD_01_M01113, V$MAZ_Q6_M00649, V$ETF_Q6_M00695, V$ZFP410_04_M02936, V$ZFP281_04_M02831, V$ZFP740_03_M02834, V$ZBP89_Q4_M01816, V$SP1SP3_Q4_M01219, V$MAZ_Q6_01_M02023, V$WT1_Q6_01_M02036, V$E2F_Q2_M00803, Klf7.1, Sp4.1, Egr1.1, Smad3.1, Bcl6b.2, Sp4.2, Zfp281.2, Zfp410.1, Zfp740.1, Zif268.1, Klf7.2, Ascl2.2, SP4_C2H2_full_monomeric_17_1, KLF14_C2H2_DBD_monomeric_14_1, SP1_C2H2_DBD_monomeric_11_1, KLF16_C2H2_DBD_monomeric_11_1, KLF13_C2H2_full_monomeric_18_1, SP3_C2H2_DBD_monomeric_11_1, SP8_C2H2_DBD_monomeric_12_1, Klf12_C2H2_DBD_monomeric_15_1

Upstream Weeder Motif

Motif1 Score	Motif1 Consensus	Motif1 Matches	Motif2 Score	Motif2 Consensus	Motif2 Matches
1.38	CGGCGT	NA	1.44	TTCGCGCG	V$E2F_03_M00516, V$E2F1_Q3_01_M00938, V$E2F2_03_M02742, V$ZF5_01_M00716, V$E2F1_Q6_01_M00940, V$E2F_Q6_01_M00920, V$E2F_Q4_02_M00939, V$E2F_Q3_01_M00918, V$E2F1_Q6_M00431, V$E2F_Q4_01_M00919, V$E2F_01_M00024, V$E2F_Q6_M00427, E2F2.1, E2F3.1, Zfp161.1

3p UTR Weeder

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif1 Model	Motif2 E-Value	Motif2 Consensus	Motif2 Matches	Motif2 Model
0.37	GCGTCG	NA	NA	0.57	GNGTGACG	NA	NA

3p UTR PITA

miRNAs	percTargets	pValue
NA

3p UTR TargetScan

miRNAs	percTargets	pValue
NA

100088 regulator of chromosome condensation 1 Details for WI1-2643G14.3 - regulator of chromosome condensation 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 100088 Tuberculist Genomic Region	110446 acetyl-Coenzyme A acetyltransferase 1 Details for - - acetyl-Coenzyme A acetyltransferase 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 110446 Tuberculist Genomic Region
13830 stomatin Details for RP23-186B18.3 - stomatin GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 13830 Tuberculist Genomic Region	16728 L1 cell adhesion molecule Details for RP23-373N8.1 - L1 cell adhesion molecule GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 16728 Tuberculist Genomic Region
17308 mannoside acetylglucosaminyltransferase 1 Details for RP23-10M12.1 - mannoside acetylglucosaminyltransferase 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 17308 Tuberculist Genomic Region	17434 molybdenum cofactor synthesis 2 Details for - - molybdenum cofactor synthesis 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 17434 Tuberculist Genomic Region
26754 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) Details for - - COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 26754 Tuberculist Genomic Region	381038 presenilin associated, rhomboid-like Details for - - presenilin associated, rhomboid-like GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 381038 Tuberculist Genomic Region
384009 GLI pathogenesis-related 2 Details for RP23-209M8.2 - GLI pathogenesis-related 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 384009 Tuberculist Genomic Region	56040 ribosomal protein, large, P1 Details for - - ribosomal protein, large, P1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 56040 Tuberculist Genomic Region
64143 v-ral simian leukemia viral oncogene homolog B (ras related) Details for - - v-ral simian leukemia viral oncogene homolog B (ras related) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 64143 Tuberculist Genomic Region	66046 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 Details for - - NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66046 Tuberculist Genomic Region
66169 translocase of outer mitochondrial membrane 7 homolog (yeast) Details for - - translocase of outer mitochondrial membrane 7 homolog (yeast) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66169 Tuberculist Genomic Region	66925 succinate dehydrogenase complex, subunit D, integral membrane protein Details for UNQ5809 - succinate dehydrogenase complex, subunit D, integral membrane protein GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66925 Tuberculist Genomic Region
67037 polyamine-modulated factor 1 Details for - - polyamine-modulated factor 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67037 Tuberculist Genomic Region	67441 isochorismatase domain containing 2b Details for - - isochorismatase domain containing 2b GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67441 Tuberculist Genomic Region
68021 biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) Details for - - biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68021 Tuberculist Genomic Region	68636 fumarylacetoacetate hydrolase domain containing 1 Details for MNCb-4134 - fumarylacetoacetate hydrolase domain containing 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68636 Tuberculist Genomic Region
98415 nuclear casein kinase and cyclin-dependent kinase substrate 1 Details for - - nuclear casein kinase and cyclin-dependent kinase substrate 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 98415 Tuberculist Genomic Region	102115 deoxyhypusine hydroxylase/monooxygenase Details for - - deoxyhypusine hydroxylase/monooxygenase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 102115 Tuberculist Genomic Region
12972 crystallin, zeta Details for - - crystallin, zeta GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 12972 Tuberculist Genomic Region	17997 neural precursor cell expressed, developmentally down-regulated gene 1 Details for - - neural precursor cell expressed, developmentally down-regulated gene 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 17997 Tuberculist Genomic Region
242705 E2F transcription factor 2 Details for RP23-118A9.2 - E2F transcription factor 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 242705 Tuberculist Genomic Region	60530 fidgetin-like 1 Details for RP23-373H2.1 - fidgetin-like 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 60530 Tuberculist Genomic Region
64934 pescadillo homolog 1, containing BRCT domain (zebrafish) Details for RP23-81P12.1 - pescadillo homolog 1, containing BRCT domain (zebrafish) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 64934 Tuberculist Genomic Region	65103 ADP-ribosylation factor-like 6 interacting protein 6 Details for RP23-265N10.1 - ADP-ribosylation factor-like 6 interacting protein 6 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 65103 Tuberculist Genomic Region
67381 mediator complex subunit 4 Details for - - mediator complex subunit 4 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67381 Tuberculist Genomic Region	68090 Yip1 interacting factor homolog A (S. cerevisiae) Details for - - Yip1 interacting factor homolog A (S. cerevisiae) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68090 Tuberculist Genomic Region
68153 general transcription factor II E, polypeptide 2 (beta subunit) Details for - - general transcription factor II E, polypeptide 2 (beta subunit) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68153 Tuberculist Genomic Region	69151 leucine zipper and CTNNBIP1 domain containing Details for RP23-153G17.1 - leucine zipper and CTNNBIP1 domain containing GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 69151 Tuberculist Genomic Region
72621 PDZ domain containing 11 Details for RP23-213F21.2 - PDZ domain containing 11 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 72621 Tuberculist Genomic Region	77605 H2A histone family, member V Details for RP23-74L9.1 - H2A histone family, member V GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 77605 Tuberculist Genomic Region
20135 ribonucleotide reductase M2 Details for - - ribonucleotide reductase M2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 20135 Tuberculist Genomic Region	21933 tumor necrosis factor receptor superfamily, member 10b Details for - - tumor necrosis factor receptor superfamily, member 10b GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 21933 Tuberculist Genomic Region
52653 NudC domain containing 2 Details for RP23-382C18.4 - NudC domain containing 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 52653 Tuberculist Genomic Region	52679 E2F transcription factor 7 Details for - - E2F transcription factor 7 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 52679 Tuberculist Genomic Region
66140 spindle and kinetochore associated complex subunit 2 Details for RP23-352L3.5 - spindle and kinetochore associated complex subunit 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66140 Tuberculist Genomic Region	68730 dihydrouridine synthase 1-like (S. cerevisiae) Details for RP23-99M13.5 - dihydrouridine synthase 1-like (S. cerevisiae) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68730 Tuberculist Genomic Region
15388 heterogeneous nuclear ribonucleoprotein L Details for - - heterogeneous nuclear ribonucleoprotein L GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 15388 Tuberculist Genomic Region	72155 centromere protein N Details for - - centromere protein N GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 72155 Tuberculist Genomic Region
14194 fumarate hydratase 1 Details for - - fumarate hydratase 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 14194 Tuberculist Genomic Region

TargetScan_125 megaCluster: 11 Residual: 0.23

Summary

Members

Details for WI1-2643G14.3 - regulator of chromosome condensation 1

Details for - - acetyl-Coenzyme A acetyltransferase 1

Details for RP23-186B18.3 - stomatin

Details for RP23-373N8.1 - L1 cell adhesion molecule

Details for RP23-10M12.1 - mannoside acetylglucosaminyltransferase 1

Details for - - molybdenum cofactor synthesis 2

Details for - - COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

Details for - - presenilin associated, rhomboid-like

Details for RP23-209M8.2 - GLI pathogenesis-related 2

Details for - - ribosomal protein, large, P1

Details for - - v-ral simian leukemia viral oncogene homolog B (ras related)

Details for - - NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5

Details for - - translocase of outer mitochondrial membrane 7 homolog (yeast)

Details for UNQ5809 - succinate dehydrogenase complex, subunit D, integral membrane protein

Details for - - polyamine-modulated factor 1

Details for - - isochorismatase domain containing 2b

Details for - - biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)

Details for MNCb-4134 - fumarylacetoacetate hydrolase domain containing 1

Details for - - nuclear casein kinase and cyclin-dependent kinase substrate 1

Details for - - deoxyhypusine hydroxylase/monooxygenase

Details for - - crystallin, zeta

Details for - - neural precursor cell expressed, developmentally down-regulated gene 1

Details for RP23-118A9.2 - E2F transcription factor 2

Details for RP23-373H2.1 - fidgetin-like 1

Details for RP23-81P12.1 - pescadillo homolog 1, containing BRCT domain (zebrafish)

Details for RP23-265N10.1 - ADP-ribosylation factor-like 6 interacting protein 6

Details for - - mediator complex subunit 4

Details for - - Yip1 interacting factor homolog A (S. cerevisiae)

Details for - - general transcription factor II E, polypeptide 2 (beta subunit)

Details for RP23-153G17.1 - leucine zipper and CTNNBIP1 domain containing

Details for RP23-213F21.2 - PDZ domain containing 11

Details for RP23-74L9.1 - H2A histone family, member V

Details for - - ribonucleotide reductase M2

Details for - - tumor necrosis factor receptor superfamily, member 10b

Details for RP23-382C18.4 - NudC domain containing 2

Details for - - E2F transcription factor 7

Details for RP23-352L3.5 - spindle and kinetochore associated complex subunit 2

Details for RP23-99M13.5 - dihydrouridine synthase 1-like (S. cerevisiae)

Details for - - heterogeneous nuclear ribonucleoprotein L

Details for - - centromere protein N

Details for - - fumarate hydratase 1

GO Terms

3p UTR PITA