TargetScan_178 megaCluster: 10 Residual: 0.21 | Macrophage Network Portal

Summary

Title	Cluster	Residual	Bicluster Conditions	Residual Permutation P-Value	Var. Exp. First PC	Var. Exp. First PC Perm. P-Value
TargetScan_178	10	0.21	15	0	0.92179	0

Members

Displaying 1 - 38 of 38

110639 phosphoribosyl pyrophosphate synthetase 2 Details for RP23-139P21.4 - phosphoribosyl pyrophosphate synthetase 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 110639 Tuberculist Genomic Region	13860 epidermal growth factor receptor pathway substrate 8 Details for - - epidermal growth factor receptor pathway substrate 8 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 13860 Tuberculist Genomic Region
14420 galactosylceramidase Details for - - galactosylceramidase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 14420 Tuberculist Genomic Region	15107 hydroxyacyl-Coenzyme A dehydrogenase Details for - - hydroxyacyl-Coenzyme A dehydrogenase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 15107 Tuberculist Genomic Region
20440 beta galactoside alpha 2,6 sialyltransferase 1 Details for - - beta galactoside alpha 2,6 sialyltransferase 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 20440 Tuberculist Genomic Region	22275 uroporphyrinogen decarboxylase Details for RP23-419D6.3 - uroporphyrinogen decarboxylase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 22275 Tuberculist Genomic Region
235132 zinc finger and BTB domain containing 44 Details for - - zinc finger and BTB domain containing 44 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 235132 Tuberculist Genomic Region	239667 DIP2 disco-interacting protein 2 homolog B (Drosophila) Details for - - DIP2 disco-interacting protein 2 homolog B (Drosophila) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 239667 Tuberculist Genomic Region
241066 calcium response factor Details for - - calcium response factor GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 241066 Tuberculist Genomic Region	60455 transmembrane protein 8 (five membrane-spanning domains) Details for - - transmembrane protein 8 (five membrane-spanning domains) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 60455 Tuberculist Genomic Region
67468 monocyte to macrophage differentiation-associated Details for RP23-220F20.1 - monocyte to macrophage differentiation-associated GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67468 Tuberculist Genomic Region	70088 MYST/Esa1-associated factor 6 Details for RP23-325M14.8 - MYST/Esa1-associated factor 6 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 70088 Tuberculist Genomic Region
72278 cell cycle progression 1 Details for - - cell cycle progression 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 72278 Tuberculist Genomic Region	72662 DIS3 mitotic control homolog (S. cerevisiae) Details for - - DIS3 mitotic control homolog (S. cerevisiae) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 72662 Tuberculist Genomic Region
78771 multiple C2 domains, transmembrane 1 Details for - - multiple C2 domains, transmembrane 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 78771 Tuberculist Genomic Region	105148 isoleucine-tRNA synthetase Details for - - isoleucine-tRNA synthetase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 105148 Tuberculist Genomic Region
105727 solute carrier family 38, member 1 Details for - - solute carrier family 38, member 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 105727 Tuberculist Genomic Region	106952 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Details for - - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 106952 Tuberculist Genomic Region
140481 mannosidase 2, alpha 2 Details for - - mannosidase 2, alpha 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 140481 Tuberculist Genomic Region	140580 engulfment and cell motility 1 Details for - - engulfment and cell motility 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 140580 Tuberculist Genomic Region
170707 ubiquitin specific peptidase 48 Details for RP23-277N22.2 - ubiquitin specific peptidase 48 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 170707 Tuberculist Genomic Region	207818 small cell adhesion glycoprotein Details for - - small cell adhesion glycoprotein GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 207818 Tuberculist Genomic Region
22121 ribosomal protein L13A Details for - - ribosomal protein L13A GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 22121 Tuberculist Genomic Region	24017 ring finger protein 13 Details for - - ring finger protein 13 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 24017 Tuberculist Genomic Region
241633 ATPase, class I, type 8B, member 4 Details for RP23-460B5.1 - ATPase, class I, type 8B, member 4 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 241633 Tuberculist Genomic Region	252972 two pore channel 1 Details for - - two pore channel 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 252972 Tuberculist Genomic Region
26465 zinc finger protein 146 Details for - - zinc finger protein 146 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 26465 Tuberculist Genomic Region	28028 mitochondrial ribosomal protein L50 Details for RP23-34B24.3 - mitochondrial ribosomal protein L50 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 28028 Tuberculist Genomic Region
28042 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) Details for - - ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 28042 Tuberculist Genomic Region	56752 aldehyde dehydrogenase 9, subfamily A1 Details for - - aldehyde dehydrogenase 9, subfamily A1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 56752 Tuberculist Genomic Region
57750 WD repeat domain 12 Details for MNCb-5414 - WD repeat domain 12 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 57750 Tuberculist Genomic Region	67486 polymerase (RNA) III (DNA directed) polypeptide G Details for - - polymerase (RNA) III (DNA directed) polypeptide G GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67486 Tuberculist Genomic Region
68023 peptide deformylase (mitochondrial) Details for - - peptide deformylase (mitochondrial) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68023 Tuberculist Genomic Region	68801 ELOVL family member 5, elongation of long chain fatty acids (yeast) Details for - - ELOVL family member 5, elongation of long chain fatty acids (yeast) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68801 Tuberculist Genomic Region
69048 solute carrier family 30 (zinc transporter), member 5 Details for - - solute carrier family 30 (zinc transporter), member 5 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 69048 Tuberculist Genomic Region	69930 zinc finger protein 715 Details for - - zinc finger protein 715 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 69930 Tuberculist Genomic Region
73910 Rho GTPase activating protein 18 Details for - - Rho GTPase activating protein 18 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 73910 Tuberculist Genomic Region	97998 DEP domain containing MTOR-interacting protein Details for - - DEP domain containing MTOR-interacting protein GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 97998 Tuberculist Genomic Region

TFBS DB TF

TFs	percTargets	pValue
EWSR1-FLI1_MA0149.1, V_EWSR1FLI1_01_M02252	0.868421, 0.868421	0.00000223

GO Terms

Displaying 1 - 1 of 1

GO Terms
NA

Upstream MEME Motif

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif2 E-Value	Motif2 Consensus	Motif2 Matches
0.67	GGCYCCGCCYC	SP1_MA0079.1, Klf4_MA0039.2, SP1_MA0079.2, Pax5_MA0014.1, V$SP1_Q6_M00196, V$GC_01_M00255, V$SP1_Q6_01_M00931, V$SP1_Q4_01_M00932, V$SP2_01_M01783, V$SP4_03_M02810, V$SP1_Q2_01_M00933, V$SP1_01_M00008, V$SP4_Q5_M01273, V$SP1_02_M01303, V$ETF_Q6_M00695, V$E2F3_Q6_M02089, V$KLF7_03_M02773, V$EGR1_Q6_M01873, V$SP1_03_M02281, V$SP1SP3_Q4_M01219, V$KROX_Q6_M00982, V$SMAD4_04_M02898, V$BCL6B_04_M02844, V$EGR1_06_M02744, V$SP4_04_M02914, V$ZFP410_04_M02936, V$UF1H3BETA_Q6_M01068, V$ZFP281_01_M01597, Sp4.1, Klf7.1, Egr1.1, Smad3.1, Bcl6b.2, Sp4.2, Zfp410.1, Zfp740.1, Zif268.1, Zfp281.2, KLF14_C2H2_DBD_monomeric_14_1, SP1_C2H2_DBD_monomeric_11_1, SP4_C2H2_full_monomeric_17_1, KLF16_C2H2_DBD_monomeric_11_1	1.2	AAAAKAAAWNAA	NA

Upstream Weeder Motif

Motif1 Score	Motif1 Consensus	Motif1 Matches	Motif2 Score	Motif2 Consensus	Motif2 Matches
1.25	ACGGCG	NA	1.3	CTGCGCCG	NA

3p UTR Weeder

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif1 Model	Motif2 E-Value	Motif2 Consensus	Motif2 Matches	Motif2 Model
0.48	CGAACG	NA	NA	0.58	GGNGAATC	NA	NA

3p UTR PITA

miRNAs	percTargets	pValue
mmu-miR-487b	0.352941	0.00000217

3p UTR TargetScan

miRNAs	percTargets	pValue
mmu-let-7f	0.111111	0.00000194

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