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- ubiquitin-protein ligase activity
- signal transducer activity
- intracellular
- cytoplasm
- endoplasmic reticulum
- endoplasmic reticulum membrane
- signal transduction
- zinc ion binding
- positive regulation of cell death
- membrane
- integral component of membrane
- positive regulation of macroautophagy
- ligase activity
- ER-associated ubiquitin-dependent protein catabolic process
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- proteasome-mediated ubiquitin-dependent protein catabolic process
- metal ion binding
- protein autoubiquitination
- perinuclear endoplasmic reticulum
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