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- negative regulation of transcription from RNA polymerase II promoter
- nucleotide binding
- catalytic activity
- cyclic-nucleotide phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
- intracellular
- nucleus
- cytoplasm
- mitochondrial matrix
- endoplasmic reticulum
- Golgi apparatus
- cytosol
- plasma membrane
- cAMP catabolic process
- protein targeting to mitochondrion
- signal transduction
- phosphoric diester hydrolase activity
- drug binding
- metabolic process
- positive regulation of gene expression
- membrane
- hydrolase activity
- cAMP-mediated signaling
- cGMP-mediated signaling
- axon
- dendrite
- cAMP binding
- cGMP binding
- negative regulation of cAMP biosynthetic process
- TPR domain binding
- negative regulation of protein import into nucleus, translocation
- cellular response to drug
- GAF domain binding
- cellular response to macrophage colony-stimulating factor stimulus
- presynaptic membrane
- protein homodimerization activity
- negative regulation of vascular permeability
- positive regulation of vascular permeability
- membrane raft
- cGMP catabolic process
- metal ion binding
- perinuclear region of cytoplasm
- positive regulation of inflammatory response
- establishment of endothelial barrier
- cellular response to mechanical stimulus
- cellular response to cGMP
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
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