Rv0955 FIG021574: Possible membrane protein related to de Novo purine biosynthesis


Product Feature Type Start End Strand Length AA Length is TF
Rv0955 FIG021574: Possible membrane protein related to de Novo purine biosynthesis CDS 1066078 1067445 + 1 368 455 FALSE

Rv0955 (FIG021574: Possible membrane protein related to de Novo purine biosynthesis) is predicted to be co-regulated in modules bicluster_0145 with residual 0.56 and bicluster_0468 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.16 for bicluster_0145 and 14.00 and 16.00 for bicluster_0468 respectively.

These modules are enriched for following go terms: riboflavin metabolic process, riboflavin biosynthetic process, flavin-containing compound metabolic pro..., flavin-containing compound biosynthetic ... .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-1.358 1066087 1066078
Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv0955_MT0982 integral membrane protein
Operon # Operon
637 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608095 NP_215470.1 Run



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: