Rv1001 Arginine deiminase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1001 arcA Arginine deiminase (EC CDS 1117185 1118393 + 1 209 402 FALSE

Rv1001 (Arginine deiminase (EC is predicted to be co-regulated in modules bicluster_0080 with residual 0.51 and bicluster_0193 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0080 and 0.00 and 0.04 for bicluster_0193 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:08
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18056 MT1030 1293
Product (LegacyBRC) Product (RefSeq)
Arginine deiminase arginine deiminase
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Arginine deiminase Arginine and proline metabolism
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Arginine and proline metabolism

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Metabolic pathways

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Biosynthesis of secondary metabolites

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608141 NP_215517.1 Run

arginine deiminase activity

arginine deiminase activity

Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3.
GO Category: 
Total items in this category:  

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
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No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.110000 0.62

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: