Rv1391 Phosphopantothenoylcysteine decarboxylase (EC / Phosphopantothenoylcysteine synthetase (EC

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1391 dfp Phosphopantothenoylcysteine decarboxylase (EC / Phosphopantothenoylcysteine synthetase (... CDS 1565441 1566697 + 1 257 418 FALSE

Rv1391 (Phosphopantothenoylcysteine decarboxylase (EC / Phosphopantothenoylcysteine synthetase (EC is predicted to be co-regulated in modules bicluster_0142 with residual 0.59 and bicluster_0515 with residual 0.56.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 420.00 and 7,300.00 for bicluster_0142 and 240.00 and 390.00 for bicluster_0515 respectively.

These modules are enriched for following go terms: DNA topological change, glutamate metabolic process, dicarboxylic acid biosynthetic process, DNA conformation change, DNA topoisomerase activity .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:16
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18873 MT1436 3215
Product (LegacyBRC) Product (RefSeq)
Coenzyme A biosynthesis bifunctional protein coaBC bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Operon # Operon
932 -
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Pantothenate and CoA biosynthesis

Total items in this category:  


Metabolic pathways

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608530 NP_215907.1 Run

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: