Rv1614 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-)

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1614 lgt Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) CDS 1813171 1814577 + 1 407 468 FALSE

Rv1614 (Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-)) is predicted to be co-regulated in modules bicluster_0208 with residual 0.56 and bicluster_0269 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2,200.00 and 230.00 for bicluster_0208 and 150.00 and 1,600.00 for bicluster_0269 respectively.

These modules are enriched for following go terms: tryptophan metabolic process, indolalkylamine metabolic process, indole-containing compound metabolic pro..., cellular biogenic amine metabolic proces..., active transmembrane transporter activit..., transporter activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS Re-Annotated Start Tuberculist Annotated Start
-1.532 879 1814050 1813168 1813171
Product (LegacyBRC) Product (RefSeq)
Prolipoprotein diacylglyceryl transferase prolipoprotein diacylglyceryl transferase
Operon # Operon
1059 - -
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608752 NP_216130.1 Run

integral to plasma membrane

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
GO Category: 
Total items in this category:  



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.560000 1.77

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: