Rv1688 DNA-3-methyladenine glycosylase II (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1688 mpg DNA-3-methyladenine glycosylase II (EC CDS 1912979 1913590 + 612 203 FALSE

Rv1688 (DNA-3-methyladenine glycosylase II (EC is predicted to be co-regulated in modules bicluster_0115 with residual 0.48 and bicluster_0398 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 50.00 and 1,500.00 for bicluster_0115 and 3.30 and 23.00 for bicluster_0398 respectively.

These modules are enriched for following go terms: ligase activity, forming carbon-nitrogen....

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:42
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-15056 MT1727.1 1279
Product (LegacyBRC) Product (RefSeq)
Putative 3-methyladenine DNA glycosylase 3-methyladenine DNA glycosylase
Operon # Operon
1103 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Base excision repair

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608826 NP_216204.1 Run
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.580000 0.78

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: