Rv2436 Ribokinase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2436 rbsK Ribokinase (EC CDS 2733230 2734144 + 915 304 FALSE

Rv2436 (Ribokinase (EC is predicted to be co-regulated in modules bicluster_0029 with residual 0.45 and bicluster_0140 with residual 0.62.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3.30 and 4.20 for bicluster_0029 and 0.00 and 0.00 for bicluster_0140 respectively.

These modules are enriched for following go terms: nucleobase-containing compound catabolic..., aromatic compound catabolic process, macromolecule catabolic process, cellular nitrogen compound catabolic pro..., heterocycle catabolic process, organic cyclic compound catabolic proces..., deoxyribonuclease activity, exonuclease activity .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.328 2733293 2733230
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Ribokinase Pentose phosphate pathway
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Pentose phosphate pathway

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609573 NP_216952.1 Run

ribokinase activity

ribokinase activity

Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.840000 2.48

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: