Rv3065 Multidrug resistance protein mmr


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3065 mmr Multidrug resistance protein mmr CDS 3430387 3430710 + 324 107 FALSE

Rv3065 (Multidrug resistance protein mmr) is predicted to be co-regulated in modules bicluster_0385 with residual 0.48 and bicluster_0534 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.63 and 9.20 for bicluster_0385 and 0.00 and 0.02 for bicluster_0534 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 14:56
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18313 MT3150.1 1992
Product (LegacyBRC) Product (RefSeq)
Multidrug resistance protein mmr multidrugs-transport integral membrane protein MMR
Operon # Operon
2009 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
57117052 YP_177922.1 Run

efflux transmembrane transporter activity

efflux transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO Category: 
Total items in this category:  

transmembrane transporter activity

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.550000 1.07

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: