P9WNX1 folA, dfrA, Rv2763c, MTV002.28c | MTB Network Portal

Summary

Source: Uniprot proteome:up000001584

Title	id	ORF names	Protein names	PubMed ID	Short	Synonyms	EnsemblBacteria
P9WNX1 DYR_MYCTU	Rv2763c Dihydrofolate reductase (EC 1.5.1.3)	MTV002.28c	Dihydrofolate reductase (EC 1.5.1.3)	9634230, 10623528, 16648861	folA	folA, dfrA, Rv2763c, MTV002.28c

Structure Details

Binding Site
27 27 Substrate., 32 32 Substrate., 60 60 Substrate., 80 80 NADP, via carbonyl oxygen., 100 100 Substrate., 113 113 Substrate.

Domain/Family Details

Domain Extent	InterPro	Pfam	ProDom	Region	Similarity	SUPFAM
DOMAIN 1 158 DHFR.		PF00186			Belongs to the dihydrofolate reductase family., Contains 1 DHFR (dihydrofolate reductase) domain.	SSF53597

Domain/Family DBs

Gene3D	HAMAP	PANTHER	Pfam	PIRSF	PRINTS	ProDom	PROSITE	SMART	SUPFAM
3.40.430.10,			PF00186	PIRSF000194,	PR00070,		PS00075, PS51330		SSF53597

SSGCID Target Details

SSGCID ID

3D Details

PDB	Protein Model Portal

Pathway Details

EC number	KEGG KO	UniPathway
1.5.1.3		Cofactor biosynthesis, tetrahydrofolate biosynthesis, 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Phylogenetic

HOGENOM	KEGG KO	OMA	OrthoDB