Methanococcus maripaludis S2 Module 27 Residual: 0.34

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Summary

Residual: 0.34 Score: -13.5348 version: mmp_cmonkey_11_Oct_11

Members

MMP0003 2-oxoglutarate oxidoreductase alpha subunit (NCBI)

Details for MMP0003 - 2-oxoglutarate oxidoreductase alpha subunit (NCBI)

GO Terms: GO:0006118, GO:0047553

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0003

Tuberculist Genomic Region

MMP1196 conserved hypothetical protein (NCBI)

Details for MMP1196 - conserved hypothetical protein (NCBI)

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1196

Tuberculist Genomic Region

MMP0006 Conserved hypothetical protein (NCBI)

Details for MMP0006 - Conserved hypothetical protein (NCBI)

GO Terms: GO:0008152, GO:0003824, GO:0003856

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0006

Tuberculist Genomic Region

MMP1242 Quinolinate synthetase A (NCBI)

Details for MMP1242 - Quinolinate synthetase A (NCBI)

GO Terms: GO:0009435, GO:0008987, GO:0003908

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1242

Tuberculist Genomic Region

MMP0073 Argininosuccinate synthase (NCBI)

Details for MMP0073 - Argininosuccinate synthase (NCBI)

GO Terms: GO:0006526, GO:0005524, GO:0004055

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0073

Tuberculist Genomic Region

MMP1310 IMP cyclohydrolase (NCBI)

Details for MMP1310 - IMP cyclohydrolase (NCBI)

GO Terms: GO:0006188, GO:0003937

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1310

Tuberculist Genomic Region

MMP0103 conserved hypothetical protein (NCBI)

Details for MMP0103 - conserved hypothetical protein (NCBI)

GO Terms: GO:0008152, GO:0009228, GO:0003824

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0103

Tuberculist Genomic Region

MMP1311 ferredoxin (NCBI)

Details for MMP1311 - ferredoxin (NCBI)

GO Terms: GO:0006118, GO:0009055, GO:0051536

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1311

Tuberculist Genomic Region

MMP0135 Threonine synthase (NCBI)

Details for MMP0135 - Threonine synthase (NCBI)

GO Terms: GO:0009088, GO:0004795, GO:0030170

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0135

Tuberculist Genomic Region

MMP1497 conserved hypothetical protein (NCBI)

Details for MMP1497 - conserved hypothetical protein (NCBI)

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1497

Tuberculist Genomic Region

MMP0136 3-isopropylmalate dehydratase small subunit (NCBI)

Details for MMP0136 - 3-isopropylmalate dehydratase small subunit (NCBI)

GO Terms: GO:0009098, GO:0009316, GO:0003861, GO:0047508

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0136

Tuberculist Genomic Region

MMP1498 conserved hypothetical protein (NCBI)

Details for MMP1498 - conserved hypothetical protein (NCBI)

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1498

Tuberculist Genomic Region

MMP0160 coenzyme F390 synthetase (NCBI)

Details for MMP0160 - coenzyme F390 synthetase (NCBI)

GO Terms: GO:0008152, GO:0047475

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0160

Tuberculist Genomic Region

MMP1510 Asp-tRNAAsn/Glu-tRNAGln amidotransferase subunit A (NCBI)

Details for MMP1510 - Asp-tRNAAsn/Glu-tRNAGln amidotransferase subunit A (NCBI)

GO Terms: GO:0006412, GO:0050567, GO:0050566, GO:0004040

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1510

Tuberculist Genomic Region

MMP0261 DNA directed RNA polymerase; subunit L (NCBI)

Details for MMP0261 - DNA directed RNA polymerase; subunit L (NCBI)

GO Terms: GO:0006350, GO:0003677, GO:0003902, GO:0003899, GO:0003900, GO:0046983, GO:0003901

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0261

Tuberculist Genomic Region

MMP1592 Tryptophanyl-tRNA synthetase (NCBI)

Details for MMP1592 - Tryptophanyl-tRNA synthetase (NCBI)

GO Terms: GO:0006436, GO:0005737, GO:0005524, GO:0004830

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1592

Tuberculist Genomic Region

MMP0553 Ornithine carbamoyltransferase (NCBI)

Details for MMP0553 - Ornithine carbamoyltransferase (NCBI)

GO Terms: GO:0006520, GO:0009348, GO:0004585, GO:0016597

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0553

Tuberculist Genomic Region

MMP1593 conserved hypothetical protein (NCBI)

Details for MMP1593 - conserved hypothetical protein (NCBI)

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1593

Tuberculist Genomic Region

MMP0654 Ketol-acid reductoisomerase (NCBI)

Details for MMP0654 - Ketol-acid reductoisomerase (NCBI)

GO Terms: GO:0009082, GO:0004455, GO:0050662

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0654

Tuberculist Genomic Region

MMP1701 Amino acid-binding ACT (NCBI)

Details for MMP1701 - Amino acid-binding ACT (NCBI)

GO Terms: GO:0008152, GO:0016597

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1701

Tuberculist Genomic Region

MMP0879 Seryl-tRNA synthetase (NCBI)

Details for MMP0879 - Seryl-tRNA synthetase (NCBI)

GO Terms: GO:0006434, GO:0005737, GO:0005524, GO:0004828

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP0879

Tuberculist Genomic Region

MMP1702 Homoserine dehydrogenase (NCBI)

Details for MMP1702 - Homoserine dehydrogenase (NCBI)

GO Terms: GO:0008652, GO:0004412

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1702

Tuberculist Genomic Region

MMP1101 Aminotransferase (subgroup II) similar to Acetylornithine aminotransferase (NCBI)

Details for MMP1101 - Aminotransferase (subgroup II) similar to Acetylornithine aminotransferase (NCBI)

GO Terms: GO:0006525, GO:0030170, GO:0003992

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1101

Tuberculist Genomic Region

MMP1018 (R)-citramalate synthase (NCBI)

Details for MMP1018 - (R)-citramalate synthase (NCBI)

GO Terms: GO:0019752, GO:0046912

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1018

Tuberculist Genomic Region

MMP1139 Thiamine monophosphate synthase (NCBI)

Details for MMP1139 - Thiamine monophosphate synthase (NCBI)

GO Terms: GO:0009228, GO:0004789

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1139

Tuberculist Genomic Region

MMP1588 D-3-phosphoglycerate dehydrogenase (NCBI)

Details for MMP1588 - D-3-phosphoglycerate dehydrogenase (NCBI)

GO Terms: GO:0006564, GO:0016597, GO:0004617, GO:0051287

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1588

Tuberculist Genomic Region

MMP1149 3-isopropylmalate dehydratase (NCBI)

Details for MMP1149 - 3-isopropylmalate dehydratase (NCBI)

GO Terms: GO:0009098, GO:0051539, GO:0003861, GO:0047508

PATRIC Pathways: NA

Essentiality: Griffin Essential: NA | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: MMP1149

Tuberculist Genomic Region

Displaying 1 - 27 of 27

Motifs

Motif 1: e-value: 0.034 e-value: 2000

Module Plots

Regulation

Regulator Interaction Influence Weight Other Influences

MMP0499

conserved hypothetical protein (NCBI)
 down-regulates -0.44

MMP0499

MMP1304

Response regulator receiver (NCBI)
 down-regulates -0.27

MMP1304

MMP1447

Cro repressor family Helix-turn-helix motif containing protein (NCBI)
 down-regulates -0.22

MMP1447

MMP0052

Conserved Hypothetical protein with 2 CBS domains (NCBI)

MMP1304

Response regulator receiver (NCBI)
 down-regulates -0.16

MMP0052

MMP1304

MMP0097

Transcriptional regulator protein, Helix-turn-helix motif (NCBI)

MMP0465

conserved hypothetical archaeal protein (NCBI)
 down-regulates -0.11

MMP0097

MMP0465

GO Enrichment

Category: BP
Category GO ID GO Term Annotated Expected Significant p-value
BP GO:0006805 xenobiotic metabolic process 3 0.05 1 0.0460
BP GO:0009410 response to xenobiotic stimulus 3 0.05 1 0.0460
BP GO:0010124 phenylacetate catabolic process 3 0.05 1 0.0460
BP GO:0042178 xenobiotic catabolic process 3 0.05 1 0.0460
BP GO:0042537 benzene-containing compound metabolic pr... 3 0.05 1 0.0460
BP GO:0070887 cellular response to chemical stimulus 3 0.05 1 0.0460
BP GO:0071466 cellular response to xenobiotic stimulus 3 0.05 1 0.0460
BP GO:0072329 monocarboxylic acid catabolic process 3 0.05 1 0.0460
Category: MF
Category GO ID GO Term Annotated Expected Significant p-value
MF GO:0016835 carbon-oxygen lyase activity 13 0.34 3 0.0036
MF GO:0003861 3-isopropylmalate dehydratase activity 4 0.10 2 0.0037
MF GO:0016829 lyase activity 27 0.70 4 0.0039
MF GO:0016597 amino acid binding 7 0.18 2 0.0124
MF GO:0031406 carboxylic acid binding 7 0.18 2 0.0124
MF GO:0043177 organic acid binding 7 0.18 2 0.0124
MF GO:0016836 hydro-lyase activity 11 0.28 2 0.0304
MF GO:0048037 cofactor binding 32 0.83 3 0.0455

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