Organism : Bacillus cereus ATCC14579 | Module List :
BC0073

Bvg accessory factor (NCBI ptt file)

CircVis
Functional Annotations (7)
Function System
Putative transcriptional regulator, homolog of Bvg accessory factor cog/ cog
pantothenate kinase activity go/ molecular_function
transcription activator activity go/ molecular_function
positive regulation of transcription, DNA-dependent go/ biological_process
Pantothenate and CoA biosynthesis kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
baf tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0073
(Mouseover regulator name to see its description)

BC0073 is regulated by 30 influences and regulates 11 modules.
Regulators for BC0073 (30)
Regulator Module Operator
BC0057 240 tf
BC0073 240 tf
BC0082 240 tf
BC0122 240 tf
BC1531 240 tf
BC1537 240 tf
BC1850 240 tf
BC2558 240 tf
BC3062 240 tf
BC3207 240 tf
BC3332 240 tf
BC3690 240 tf
BC3813 240 tf
BC3814 240 tf
BC4316 240 tf
BC0073 329 tf
BC0082 329 tf
BC0607 329 tf
BC1075 329 tf
BC1427 329 tf
BC1489 329 tf
BC1814 329 tf
BC1819 329 tf
BC2351 329 tf
BC3356 329 tf
BC3982 329 tf
BC4010 329 tf
BC4374 329 tf
BC5200 329 tf
BC5411 329 tf
Regulated by BC0073 (11)
Module Residual Genes
150 0.51 31
207 0.26 16
237 0.39 24
240 0.45 25
329 0.49 19
379 0.50 24
418 0.27 16
450 0.40 23
451 0.44 22
467 0.43 25
518 0.42 25
Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4396 2.70e-01 GagAaGaGgTGAG
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4397 4.90e+00 cggc.ggt..t.tgttGcGgG
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4572 2.00e+00 AagtAgaAgAAGgG.atg
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4573 5.00e+00 AaaGaGGaaA.aG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0073

BC0073 is enriched for 7 functions in 3 categories.
Enrichment Table (7)
Function System
Putative transcriptional regulator, homolog of Bvg accessory factor cog/ cog
pantothenate kinase activity go/ molecular_function
transcription activator activity go/ molecular_function
positive regulation of transcription, DNA-dependent go/ biological_process
Pantothenate and CoA biosynthesis kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
baf tigr/ tigrfam
Module neighborhood information for BC0073

BC0073 has total of 43 gene neighbors in modules 240, 329
Gene neighbors (43)
Gene Common Name Description Module membership
BC0036 BC0036 Thymidylate kinase (NCBI ptt file) 230, 329
BC0058 BC0058 Transcription-repair coupling factor (NCBI ptt file) 240, 484
BC0073 BC0073 Bvg accessory factor (NCBI ptt file) 240, 329
BC0074 BC0074 33 kDa chaperonin (NCBI ptt file) 240, 518
BC0109 BC0109 Serine acetyltransferase (NCBI ptt file) 240, 357
BC0110 BC0110 Cysteinyl-tRNA synthetase (NCBI ptt file) 240, 357
BC0111 BC0111 hypothetical protein (NCBI ptt file) 240, 357
BC0112 BC0112 23S rRNA methyltransferase (NCBI ptt file) 240, 357
BC0262 BC0262 Holo-[acyl-carrier protein] synthase (NCBI ptt file) 177, 329
BC0609 BC0609 Lactoylglutathione lyase (NCBI ptt file) 252, 329
BC1035 BC1035 Glycerol kinase (NCBI ptt file) 252, 329
BC1036 BC1036 Glycerol-3-phosphate dehydrogenase (NCBI ptt file) 18, 329
BC1213 BC1213 dTDP-4-dehydrorhamnose 3,5-epimerase (NCBI ptt file) 240, 451
BC1214 BC1214 dTDP-glucose 4,6-dehydratase (NCBI ptt file) 240, 451
BC1215 BC1215 dTDP-4-dehydrorhamnose reductase (NCBI ptt file) 193, 240
BC1300 BC1300 Two-component response regulator (NCBI ptt file) 252, 329
BC1301 BC1301 Two component system histidine kinase (NCBI ptt file) 252, 329
BC1516 BC1516 Chorismate synthase (NCBI ptt file) 240, 451
BC1533 BC1533 Methylglyoxal synthase (NCBI ptt file) 240, 450
BC1534 BC1534 Lmbe-related protein (NCBI ptt file) 240, 450
BC1535 BC1535 Glycosyltransferase (NCBI ptt file) 240, 450
BC1536 BC1536 Poly(A) polymerase (NCBI ptt file) 240, 450
BC1540 BC1540 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI ptt file) 329, 450
BC1541 BC1541 Pantoate--beta-alanine ligase (NCBI ptt file) 329, 450
BC1542 BC1542 Aspartate 1-decarboxylase (NCBI ptt file) 329, 450
BC1672 BC1672 Metal-dependent hydrolase related to alanyl-tRNA synthetase (NCBI ptt file) 141, 329
BC1814 BC1814 Transcriptional regulator, TetR family (NCBI ptt file) 329, 386
BC2036 BC2036 hypothetical Membrane Spanning Protein (NCBI ptt file) 159, 329
BC2037 BC2037 hypothetical Membrane Spanning Protein (NCBI ptt file) 263, 329
BC3046 BC3046 Uridine kinase (NCBI ptt file) 240, 254
BC3601 BC3601 Two-component response regulator (NCBI ptt file) 64, 329
BC3853 BC3853 ATP-dependent DNA helicase recG (NCBI ptt file) 240, 518
BC3860 BC3860 Serine/threonine protein kinase (NCBI ptt file) 240, 451
BC3861 BC3861 Protein phosphatase 2C (NCBI ptt file) 240, 451
BC3865 BC3865 Polypeptide deformylase (NCBI ptt file) 240, 467
BC3866 BC3866 Primosomal protein N' (NCBI ptt file) 240, 467
BC3867 BC3867 Phosphopantothenate-cysteine ligase (NCBI ptt file) 240, 367
BC4178 BC4178 Exodeoxyribonuclease VII small subunit (NCBI ptt file) 240, 451
BC4179 BC4179 Exodeoxyribonuclease VII large subunit (NCBI ptt file) 240, 451
BC4481 BC4481 TPR repeat protein (NCBI ptt file) 329, 385
BC4850 BC4850 None 329, 451
BC5479 BC5479 Mechanosensitive ion channel (NCBI ptt file) 88, 329
BC5485 BC5485 Glucose inhibited division protein A (NCBI ptt file) 240, 252
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0073
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend