Organism : Bacillus cereus ATCC14579 | Module List :
BC2517

Transcriptional regulator, MarR family (NCBI ptt file)

CircVis
Functional Annotations (1)
Function System
Predicted transcriptional regulators cog/ cog
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2517
(Mouseover regulator name to see its description)

BC2517 is regulated by 13 influences and regulates 84 modules.
Regulators for BC2517 (13)
Regulator Module Operator
BC0742 11 tf
BC1329 11 tf
BC1335 11 tf
BC2469 11 tf
BC2517 11 tf
BC3587 11 tf
BC5251 11 tf
BC1059 44 tf
BC1363 44 tf
BC2401 44 tf
BC2410 44 tf
BC2469 44 tf
BC2517 44 tf

Warning: BC2517 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3944 1.80e-01 gaGGAGaG
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3945 4.10e+00 AggaGCAA
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4008 4.60e-01 GGaGAGggg
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4009 3.50e+03 TCCCcC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2517

BC2517 is enriched for 1 functions in 3 categories.
Enrichment Table (1)
Function System
Predicted transcriptional regulators cog/ cog
Module neighborhood information for BC2517

BC2517 has total of 25 gene neighbors in modules 11, 44
Gene neighbors (25)
Gene Common Name Description Module membership
BC0478 BC0478 Integral membrane protein (NCBI ptt file) 11, 526
BC0672 BC0672 hypothetical protein (NCBI ptt file) 44, 494
BC0706 BC0706 Spore germination protein LC (NCBI ptt file) 11, 526
BC0772 BC0772 hypothetical protein (NCBI ptt file) 11, 526
BC1890 BC1890 Phage protein (NCBI ptt file) 44, 323
BC1892 BC1892 Phage protein (NCBI ptt file) 44, 323
BC1946 BC1946 hypothetical protein (NCBI ptt file) 44, 93
BC2175 BC2175 D-beta-hydroxybutyrate permease (NCBI ptt file) 11, 195
BC2450 BC2450 Macrolide-efflux protein (NCBI ptt file) 44, 323
BC2469 BC2469 RNA polymerase ECF-type sigma factor (NCBI ptt file) 44, 494
BC2517 BC2517 Transcriptional regulator, MarR family (NCBI ptt file) 11, 44
BC2566 BC2566 Phage protein (NCBI ptt file) 44, 195
BC2866 BC2866 Acetyltransferase (NCBI ptt file) 44, 323
BC2970 BC2970 Tetracycline resistance determinant tetV (NCBI ptt file) 11, 195
BC2982 BC2982 Fosfomycin resistance protein (NCBI ptt file) 44, 109
BC3032 BC3032 6-aminohexanoate-dimer hydrolase (NCBI ptt file) 11, 526
BC3080 BC3080 hypothetical protein (NCBI ptt file) 11, 183
BC3243 BC3243 Isochorismatase (NCBI ptt file) 44, 323
BC3482 BC3482 Glucan 1,4-alpha-maltohexaosidase precursor (NCBI ptt file) 11, 156
BC3512 BC3512 Sulfide-quinone reductase (NCBI ptt file) 11, 323
BC3529 BC3529 Microbial collagenase (NCBI ptt file) 11, 526
BC3581 BC3581 hypothetical protein (NCBI ptt file) 44, 494
BC3671 BC3671 Phosphohydrolase (MutT/nudix family protein) (NCBI ptt file) 44, 195
BC4828 BC4828 Alkaline phosphatase like protein (NCBI ptt file) 11, 349
BC5447 BC5447 Acetamide transporter (NCBI ptt file) 11, 195
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2517
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend