Organism : Bacillus cereus ATCC14579 | Module List :
BC5463

Two-component response regulator yycF (NCBI ptt file)

CircVis
Functional Annotations (6)
Function System
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cog/ cog
two-component response regulator activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
DNA binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
Two-component system kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC5463
(Mouseover regulator name to see its description)

BC5463 is regulated by 21 influences and regulates 16 modules.
Regulators for BC5463 (21)
Regulator Module Operator
BC0116 447 tf
BC1302 447 tf
BC1531 447 tf
BC3332 447 tf
BC3976 447 tf
BC3982 447 tf
BC4181 447 tf
BC4316 447 tf
BC5339 447 tf
BC5373 447 tf
BC5463 447 tf
BC0082 374 tf
BC0114 374 tf
BC0122 374 tf
BC0123 374 tf
BC1302 374 tf
BC2672 374 tf
BC3982 374 tf
BC4316 374 tf
BC4393 374 tf
BC5463 374 tf
Regulated by BC5463 (16)
Module Residual Genes
81 0.31 18
99 0.25 14
118 0.39 15
155 0.42 17
250 0.55 24
260 0.41 19
326 0.28 16
345 0.29 17
367 0.27 18
372 0.26 16
374 0.36 17
390 0.28 13
447 0.29 13
451 0.44 22
468 0.56 20
505 0.44 16
Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4658 2.70e+01 Aaa.AAAgaAggaaG
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4659 5.10e+03 GAGGtGA
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4804 5.60e+01 aatagTgtAaag.aaga.AGgagg
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4805 4.10e+03 TCCc.aatCat
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC5463

BC5463 is enriched for 6 functions in 3 categories.
Module neighborhood information for BC5463

BC5463 has total of 29 gene neighbors in modules 374, 447
Gene neighbors (29)
Gene Common Name Description Module membership
BC0005 BC0005 DNA gyrase subunit B (NCBI ptt file) 79, 374
BC0037 BC0037 DNA polymerase III, delta' subunit (NCBI ptt file) 81, 374
BC0045 BC0045 Ribonuclease M5 (NCBI ptt file) 406, 447
BC0054 BC0054 Glucosamine-1-phosphate acetyltransferase (NCBI ptt file) 447, 513
BC0064 BC0064 Spore cortex biosynthesis protein (NCBI ptt file) 222, 374
BC1197 BC1197 IG hypothetical 17542 (NCBI ptt file) 81, 447
BC1199 BC1199 ATP-NAD kinase (NCBI ptt file) 99, 447
BC3783 BC3783 ACT domain protein (NCBI ptt file) 99, 447
BC3855 BC3855 putative alkaline-shock protein (NCBI ptt file) 371, 447
BC3899 BC3899 hypothetical Cytosolic Protein (NCBI ptt file) 345, 374
BC3900 BC3900 hypothetical Cytosolic Protein (NCBI ptt file) 345, 374
BC3907 BC3907 Cell division protein ftsA (NCBI ptt file) 345, 374
BC4089 BC4089 DNA integration/recombination/invertion protein (NCBI ptt file) 273, 447
BC4090 BC4090 hypothetical protein (NCBI ptt file) 273, 447
BC4155 BC4155 Rod shape-determining protein rodA (NCBI ptt file) 99, 447
BC4290 BC4290 DNA primase (NCBI ptt file) 99, 447
BC4292 BC4292 EMG2 protein (NCBI ptt file) 371, 447
BC4442 BC4442 Cell division inhibitor MinD (NCBI ptt file) 134, 374
BC4443 BC4443 Cell division inhibitor MinC (NCBI ptt file) 242, 374
BC5129 BC5129 Exoribonuclease II (NCBI ptt file) 99, 447
BC5153 BC5153 Catabolite repression protein crh (NCBI ptt file) 221, 374
BC5154 BC5154 hypothetical Cytosolic Protein (NCBI ptt file) 345, 374
BC5156 BC5156 ATP-binding protein (P-loop) (NCBI ptt file) 345, 374
BC5157 BC5157 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (NCBI ptt file) 374, 505
BC5461 BC5461 hypothetical membrane protein yycH (NCBI ptt file) 117, 374
BC5462 BC5462 Two-component sensor kinase yycG (NCBI ptt file) 252, 374
BC5463 BC5463 Two-component response regulator yycF (NCBI ptt file) 374, 447
BC5484 BC5484 Glucose inhibited division protein B (NCBI ptt file) 367, 374
BC5486 BC5486 Thiophene and furan oxidation protein ThdF (NCBI ptt file) 367, 374
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC5463
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend