Organism : Bacillus subtilis | Module List :
BSU39050 katE

catalase 2 (RefSeq)

CircVis
Functional Annotations (10)
Function System
Catalase cog/ cog
catalase activity go/ molecular_function
iron ion binding go/ molecular_function
electron transport go/ biological_process
response to oxidative stress go/ biological_process
heme binding go/ molecular_function
Tryptophan metabolism kegg/ kegg pathway
Methane metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU39050
(Mouseover regulator name to see its description)

BSU39050 is regulated by 19 influences and regulates 0 modules.
Regulators for BSU39050 katE (19)
Regulator Module Operator
BSU04730 299 tf
BSU09690 299 tf
BSU24770 299 tf
BSU28400 299 tf
BSU00980 147 tf
BSU04730 147 tf
BSU04770 147 tf
BSU04820 147 tf
BSU09380 147 tf
BSU09690 147 tf
BSU11300 147 tf
BSU12510 147 tf
BSU21020 147 tf
BSU24770 147 tf
BSU25200 147 tf
BSU26670 147 tf
BSU27170 147 tf
BSU31680 147 tf
BSU33840 147 tf

Warning: BSU39050 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5244 9.70e-04 CcCCTcTctTtatT.aTaTac
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5245 7.20e-04 ATGTTTcgcTtcaaAaaCacaGgG
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5536 8.30e-06 aaAGGaGgAt
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5537 9.50e+00 tttt.aA.ttgcaAAAActg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU39050

BSU39050 is enriched for 10 functions in 3 categories.
Enrichment Table (10)
Function System
Catalase cog/ cog
catalase activity go/ molecular_function
iron ion binding go/ molecular_function
electron transport go/ biological_process
response to oxidative stress go/ biological_process
heme binding go/ molecular_function
Tryptophan metabolism kegg/ kegg pathway
Methane metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
Module neighborhood information for BSU39050

BSU39050 has total of 27 gene neighbors in modules 147, 299
Gene neighbors (27)
Gene Common Name Description Module membership
BSU02110 ybyB hypothetical protein (RefSeq) 231, 299
BSU02590 ycbP putative inner integral membrane protein (RefSeq) 137, 299
BSU02830 ycdF putative dehydrogenase (RefSeq) 299, 391
BSU02840 ycdG putative glycosidase (RefSeq) 147, 299
BSU04190 ydaD short chain dehydrogenase (RefSeq) 147, 203
BSU04200 ydaE hypothetical protein (RefSeq) 147, 203
BSU04340 ydaP pyruvate oxidase (RefSeq) 299, 320
BSU04370 ydaS hypothetical protein (RefSeq) 147, 203
BSU04380 ydaT hypothetical protein (RefSeq) 203, 299
BSU04400 gsiB general stress protein (RefSeq) 203, 299
BSU04430 ydbD putative manganese-containing catalase (RefSeq) 147, 203
BSU05100 yddT hypothetical protein (RefSeq) 29, 299
BSU05790 ydhK hypothetical protein (RefSeq) 147, 391
BSU07550 yflT heat stress induced protein (RefSeq) 203, 299
BSU07850 yfkM general stress protein 18 (RefSeq) 39, 299
BSU09390 ygxB putative integral inner membrane protein (RefSeq) 147, 299
BSU09530 yhdN aldo/keto reductase specific for NADPH (RefSeq) 149, 299
BSU10430 yhxD putative oxidoreductase (RefSeq) 147, 299
BSU12150 yjgB hypothetical protein (RefSeq) 147, 403
BSU12160 yjgC putative oxidoreductase (RefSeq) 147, 403
BSU12170 yjgD hypothetical protein (RefSeq) 147, 403
BSU13160 ohrB organic hydroperoxide resistance reductase B (RefSeq) 203, 299
BSU21320 yomL conserved hypothetical protein; phage SPbeta (RefSeq) 29, 299
BSU28340 ysnF putative stress response protein (RefSeq) 29, 299
BSU33530 yvaA putative oxidoreductase (RefSeq) 147, 320
BSU36670 csbD stress response protein (RefSeq) 203, 299
BSU39050 katE catalase 2 (RefSeq) 147, 299
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU39050
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend