Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_812553.1 BT_3642

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_812553.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_812553.1!

Warning: NP_812553.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6116 3.30e-02 AagAcgGGctGAGaacaTAcCC
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6117 3.50e-02 CcggGTAat.cCgaCgTAggGAac
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6208 2.30e+04 TCgGgtaCAAA
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6209 2.70e+04 GCGATTGTAAG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_812553.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_812553.1

NP_812553.1 has total of 39 gene neighbors in modules 196, 242
Gene neighbors (39)
Gene Common Name Description Module membership
NP_809117.1 BT_0204 None 196, 346
NP_809403.1 BT_0490 None 126, 242
NP_809418.1 BT_0505 None 156, 242
NP_809456.1 BT_0543 None 242, 472
NP_809459.1 BT_0546 None 80, 242
NP_809460.1 BT_0547 None 80, 242
NP_809461.1 BT_0548 None 80, 242
NP_809467.1 BT_0554 None 157, 242
NP_809468.1 BT_0555 None 242, 466
NP_809469.1 BT_0556 None 242, 466
NP_809470.1 BT_0557 None 242, 466
NP_809561.1 BT_0648 None 196, 346
NP_809562.1 thiH None 196, 346
NP_809563.1 BT_0650 None 196, 346
NP_809564.1 thiG None 196, 346
NP_809565.1 thiE None 196, 346
NP_809566.1 BT_0653 None 196, 346
NP_809912.1 BT_0999 None 167, 196
NP_810655.1 BT_1742 None 196, 297
NP_810756.1 BT_1843 None 100, 242
NP_810892.1 BT_1979 None 242, 370
NP_810945.1 BT_2032 None 196, 346
NP_810946.1 BT_2033 None 196, 427
NP_811172.1 BT_2259 None 196, 346
NP_811173.1 BT_2260 None 196, 346
NP_811181.1 BT_2268 None 196, 346
NP_811182.1 BT_2269 None 196, 346
NP_811300.1 BT_2387 None 196, 346
NP_811303.1 BT_2390 None 196, 346
NP_811309.1 BT_2396 None 196, 346
NP_811310.1 BT_2397 None 196, 346
NP_811448.1 BT_2535 None 156, 242
NP_811449.1 BT_2536 None 242, 358
NP_811583.1 BT_2671 None 196, 346
NP_812131.1 BT_3219 None 144, 196
NP_812547.1 BT_3636 None 230, 242
NP_812553.1 BT_3642 None 196, 242
NP_812654.1 BT_3743 None 64, 242
NP_813574.1 BT_4663 None 242, 382
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_812553.1
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend