Organism : Clostridium acetobutylicum | Module List :
Membrane permease, predicted cation efflux pumps (NCBI ptt file)
Functional Annotations (1)
|Membrane-fusion protein||cog/ cog|
Regulation information for CAC0141(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC0141
|Membrane-fusion protein||cog/ cog|
Module neighborhood information for CAC0141
|Gene||Common Name||Description||Module membership|
|CAC0138||CAC0138||ABC transporter, ATP-binding component (NCBI ptt file)||36, 114|
|CAC0139||CAC0139||Predicted permease (NCBI ptt file)||36, 114|
|CAC0140||CAC0140||Predicted permease (NCBI ptt file)||67, 114|
|CAC0141||CAC0141||Membrane permease, predicted cation efflux pumps (NCBI ptt file)||36, 114|
|CAC0158||glmS||Glucoseamine-fructose-6-phosphate aminotransferase (gene glmS) (NCBI ptt file)||36, 84|
|CAC0301||CAC0301||Signal peptidase II (PSP1) homolog, YAAT B.subtilis ortholog (NCBI ptt file)||36, 271|
|CAC0970||CAC0970||Isopropylmalate synthase (NCBI ptt file)||114, 127|
|CAC0971||citB||Aconitase A (NCBI ptt file)||114, 127|
|CAC0972||citC||Isocitrate dehydrogenase (NCBI ptt file)||114, 127|
|CAC1336||CAC1336||Hypothetical protein (NCBI ptt file)||114, 127|
|CAC1337||CAC1337||Spore coat protein COTJB (NCBI ptt file)||114, 127|
|CAC1338||CAC1338||Spore coat protein COTJC (NCBI ptt file)||114, 127|
|CAC1469||CAC1469||Iron-dependent transcription repressor (NCBI ptt file)||114, 127|
|CAC1572||CAC1572||Fructose-1,6-bisphosphatase (YYDE B.subtils ortholog) (NCBI ptt file)||100, 114|
|CAC1629||CAC1629||Putative intracellular protease/amidase, ThiJ family (NCBI ptt file)||36, 45|
|CAC1633||CAC1633||Protein from bacterioferritin family (NCBI ptt file)||114, 127|
|CAC1656||CAC1656||Hypothetical protein, CF-39 family (NCBI ptt file)||114, 273|
|CAC1734||CAC1734||Uncharacterized, alkaline shock induced protein (NCBI ptt file)||36, 329|
|CAC1735||CAC1735||Predicted kinase related to hydroxyacetone kinase, YLOV ortholog (NCBI ptt file)||36, 335|
|CAC1836||mutL||DNA mismatch repair enzyme, MutL (NCBI ptt file)||36, 159|
|CAC1838||CAC1838||Predicted Fe-S oxidoreductase, YMCB B.subtilis ortholog (NCBI ptt file)||36, 159|
|CAC1866||CAC1866||Putative 4-Cys ferredoxin (NCBI ptt file)||114, 127|
|CAC2243||asnB||N-terminal domain of asparagine synthase (NCBI ptt file)||100, 114|
|CAC2249||CAC2249||C-terminal domain of asparagine synthase (NCBI ptt file)||114, 300|
|CAC2565||CAC2565||NifU-related domain containing protein (NCBI ptt file)||36, 153|
|CAC2629||CAC2629||Hypothetical secreted protein (NCBI ptt file)||36, 310|
|CAC2747||CAC2747||Protein containing LysM repeats (N-terminal domain) and domain related to chitinase (NCBI ptt file)||114, 127|
|CAC2797||CAC2797||Hypothetical protein (NCBI ptt file)||114, 127|
|CAC2858||mreV||Shape-determining protein envB (HSP70 family charepones) (NCBI ptt file)||36, 63|
|CAC2880||CAC2880||Ribose 5-phosphate isomerase, RpiB (NCBI ptt file)||36, 329|
|CAC2909||CAC2909||Spore coat protein cotS related (diverged) (NCBI ptt file)||114, 190|
|CAC2968||CAC2968||Mannose-1-phosphate guanylyltransferase (NCBI ptt file)||114, 127|
|CAC3017||CAC3017||Predicted xylanase/chitin deacetylase (NCBI ptt file)||36, 335|
|CAC3018||CAC3018||Rubrerythrin (NCBI ptt file)||114, 127|
|CAC3040||CAC3040||CPSC/CAPB subfamily ATPase (NCBI ptt file)||36, 235|
|CAC3078||CAC3078||Uncharacterized secreted protein, YBBR Bacillus subtilis homolog (NCBI ptt file)||114, 142|
|CAC3138||fus||Translation elongation factor EF-G (NCBI ptt file)||36, 335|
|CAC3187||CAC3187||Predicted nucleic-acid-binding protein protein, containing HHH domain, YACK B.subtilis ortholog (NCBI ptt file)||36, 329|
|CAC3188||sms||Predicted ATP-dependent serine protease, RADA homolog (NCBI ptt file)||36, 271|
|CAC3674||CAC3674||Two CBS domain containing protein (NCBI ptt file)||114, 300|
|CAC3708||CAC3708||Hypothetical protein (NCBI ptt file)||36, 44|
|CAC3709||CAC3709||DNA segregation ATPase, FtsK/SpoIIIE family, YUKA B.subtilis ortholog (NCBI ptt file)||36, 44|
|CAC3710||CAC3710||Uncharacterized protein, YUKC B.subtilis homolog (NCBI ptt file)||36, 44|
|CAC3711||CAC3711||Hypothetical protein (NCBI ptt file)||36, 44|
|CAC3716||lonB||Lon-like ATP-dependent protease (NCBI ptt file)||36, 114|
|CAC3717||rplI||Ribosomal protein L9 (NCBI ptt file)||114, 243|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
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