Organism : Clostridium acetobutylicum | Module List :
NCAIR mutase (PurE)-related protein (NCBI ptt file)
Functional Annotations (4)
|NCAIR mutase (PurE)-related proteins||cog/ cog|
|phosphoribosylaminoimidazole carboxylase activity||go/ molecular_function|
|'de novo' IMP biosynthetic process||go/ biological_process|
|phosphoribosylaminoimidazole carboxylase complex||go/ cellular_component|
Regulation information for CAC0776(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC0776
Module neighborhood information for CAC0776
|Gene||Common Name||Description||Module membership|
|CAC0183||CAC0183||Transcriptional regulators of NagC/XylR (ROK) family, sugar kinase (NCBI ptt file)||6, 316|
|CAC0365||CAC0365||Phosphoglycerate dehydrogenase (NCBI ptt file)||256, 316|
|CAC0378||glnQ||Glutamine ABC transporter, ATP-binding protein (gene glnQ) (NCBI ptt file)||50, 316|
|CAC0770||CAC0770||Glycerol uptake facilitator protein, permease (NCBI ptt file)||30, 316|
|CAC0776||CAC0776||NCAIR mutase (PurE)-related protein (NCBI ptt file)||234, 316|
|CAC0822||CAC0822||ABC transporter, ATP-binding protein (NCBI ptt file)||234, 271|
|CAC0854||tet||Tetracycline resistance protein tetP, contain GTP-ase domain (NCBI ptt file)||241, 316|
|CAC0998||CAC0998||Homoserine dehydrogenase (NCBI ptt file)||234, 256|
|CAC0999||thrC||Threonine synthase (NCBI ptt file)||234, 256|
|CAC1058||CAC1058||Predicted membrane protein (NCBI ptt file)||163, 316|
|CAC1091||CAC1091||Aspartyl aminopeptidase (NCBI ptt file)||159, 234|
|CAC1344||xylB||Sugar kinase, possible xylulose kinase (NCBI ptt file)||284, 316|
|CAC1346||araA||L-arabinose isomerase (NCBI ptt file)||284, 316|
|CAC1366||CAC1366||Predicted membrane protein (NCBI ptt file)||234, 357|
|CAC1374||cbiP||Cobyric acid synthase CbiP (NCBI ptt file)||56, 234|
|CAC1375||cobB||Cobyrinic acid a,c-diamide synthase CobB (NCBI ptt file)||56, 234|
|CAC1377||cbiD||Cobalamin biosynthesis protein CbiD (NCBI ptt file)||56, 234|
|CAC1378||cbiT||Precorrin-6B methylase CbiT (NCBI ptt file)||56, 234|
|CAC1379||cobI/cbiL||Precorrin-2 methylase CobI/CbiL (NCBI ptt file)||56, 234|
|CAC1380||cbiF/cobM||precorrin-4 methylase cbiF (NCBI ptt file)||56, 234|
|CAC1382||cbiH/cobJ||precorrin-3 methylase (NCBI ptt file)||56, 234|
|CAC1383||CobU/CobP||Adenosyl cobinamide kinase/adenosyl cobinamide phosphate (NCBI ptt file)||56, 234|
|CAC1385||cobC||Alpha-ribazole-5'-phosphate phosphatase, CobC (NCBI ptt file)||56, 234|
|CAC1398||CAC1398||Uncharacterized protein from YqgV/UPF0045 family (NCBI ptt file)||163, 316|
|CAC1688||CAC1688||Penicillin-binding protein (NCBI ptt file)||38, 316|
|CAC1715||CAC1715||PLP-dependent aminotransferase (NCBI ptt file)||159, 234|
|CAC1721||rpiA||Primosomal protein N', superfamily II helicase (NCBI ptt file)||172, 234|
|CAC2225||CAC2225||Uncharacterized conserved protein (NCBI ptt file)||316, 339|
|CAC2268||CAC2268||Uncharacterized protein of YOHL family (NCBI ptt file)||163, 234|
|CAC2282||tgt||Queuine tRNA-ribosyltransferase, tgt (NCBI ptt file)||229, 234|
|CAC2328||CAC2328||Polysaccharide ABC transporter, ATPase component (NCBI ptt file)||234, 327|
|CAC2530||CAC2530||Predicted N-acetyltransferase (NCBI ptt file)||234, 274|
|CAC2573||CAC2573||Predicted S-adenosylmethionine-dependent methyltransferase (NCBI ptt file)||56, 234|
|CAC2721||CAC2721||Response regulator (CheY-like reciever domain and HTH-type DNA-binding domain) (NCBI ptt file)||38, 316|
|CAC2834||CAC2834||Uncharacterized conserved protein, YHAD family (NCBI ptt file)||234, 288|
|CAC2920||tenI||Thiamine monophosphate synthase (NCBI ptt file)||6, 316|
|CAC2922||thiG||Uncharacterized enzyme of thiazol biosynthesis (NCBI ptt file)||6, 316|
|CAC3014||thiC||Thiamine biosynthesis protein ThiC (NCBI ptt file)||163, 316|
|CAC3096||thiK||Hydroxyethylthiazole kinase ThiM/ThiK (FS!) (NCBI ptt file)||256, 316|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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